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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:03 AM EDT

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Showing 121–144 of 278 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cigarette Smokers Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Mobile Smoking Cessation Intervention in Enhancing Cancer Outreach in Low-Income Adult Smokers

NCT00948129
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Laboratory Biomarker Analysis, Smoking Cessation Intervention, Telephone-Based Intervention, Tobacco Cessation Counseling
Other · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
626 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2023 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 1 Interventional

Investigation of Nicotine Seeking Behavior in Current Smokers

NCT03670212
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder
Drug
Lead sponsor
Wayne State University
Other
Eligibility
21 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers

NCT00924768
View directory record Official record
Conditions
Healthy, Cigarette Smoking
Interventions
20K EU CCRE
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2013 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 3 Interventional

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

NCT06435221
View directory record Official record
Conditions
Smoking Cessation, Vaping Cessation
Interventions
Cytisinicline
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional

Testing Methods of Self-persuasion Involving Cigarette Smoking

NCT02069483
View directory record Official record
Conditions
Smoking
Interventions
Motivational Interviewing, Tailored Feedback
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2014 · Synced Oct 2, 2026, 7:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation in Current Every Day Cigarette Smokers

NCT04060446
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Medical Device, Questionnaire Administration, Tobacco Smoking
Device · Other · Behavioral
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 69 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2022 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine

NCT05994703
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
d-cycloserine, Juul e-cigarette
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Pack Inserts for Smoking Cessation

NCT04075682
View directory record Official record
Conditions
Smoking Cessation
Interventions
Inserts with efficacy messages, Pictorial warnings on packs
Other
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
387 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Ithaca, New York • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated May 13, 2024 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation for Smokers With Sleep Problems

NCT01277887
View directory record Official record
Conditions
Nicotine Dependence, Cigarette Smoking, Insomnia
Interventions
Cognitive-Behavioral Counseling, Smoking Cessation Counseling
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking in Smokers With and Without Schizophrenia

NCT04001114
View directory record Official record
Conditions
Tobacco Dependence, Schizophrenia
Interventions
Sampling Research Cigarettes
Combination Product
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Oct 2, 2026, 7:03 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Behavioral Application for Improving Smoking Cessation Among Smokers

NCT07493252
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone app-based Intervention (Actify! A app), Smartphone app-based Intervention (Actify! B app), Health Promotion and Education, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,812 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 2, 2026, 7:03 AM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2

NCT02649556
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2, CC
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
30 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
19
States / cities
Tempe, Arizona • Clearwater, Florida • Daytona Beach, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2020 · Synced Oct 2, 2026, 7:03 AM EDT
Terminated Phase 3 Interventional Results available

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

NCT01169610
View directory record Official record
Conditions
Alcoholism, Nicotine Dependence
Interventions
Varenicline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Abuse Liability Among African American and White Smokers

NCT04646668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette and Heat not burn
Combination Product
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 2, 2026, 7:03 AM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Investigation of the Impact of Smoking Status on Allergen-induced Nasal Airway Inflammation Using a Cat Hair (Felis Domesticus) Extract Nasal Allergen Challenge Model

NCT03031145
View directory record Official record
Conditions
Tobacco Smoking, Healthy Participants, E-cigarette Smokers
Interventions
Felis Domesticus
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 7, 2021 · Synced Oct 2, 2026, 7:03 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers

NCT02220465
View directory record Official record
Conditions
Sedentary Lifestyle, Cigarette Smoking
Interventions
PA+ Smoking Cessation (LMPA), Standard Care Smoking Counseling (SCC)
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 59 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

NCT02323438
View directory record Official record
Conditions
Smoking
Interventions
Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of E-Cigarettes in Menthol Smokers

NCT05949034
View directory record Official record
Conditions
E-cigarette Use, Smoking Behaviors
Interventions
JUUL E-Cigarette Device
Device
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers

NCT02590640
View directory record Official record
Conditions
Smoking
Interventions
Repetitive transcranial magnetic stimulation, MagStim Rapid2, Sham repetitive transcranial magnetic stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes

NCT03559725
View directory record Official record
Conditions
Tobacco Use
Interventions
VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C)
Other · Drug
Lead sponsor
22nd Century Group, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Phase 2 Interventional

Very Low Nicotine Cigarettes in Smokers With Schizophrenia

NCT02019459
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Very low nicotine content cigarettes, standard nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers

NCT01216735
View directory record Official record
Conditions
Tobacco Abuse Smoke
Interventions
Fluticasone, Placebo
Drug
Lead sponsor
University of Miami
Other
Eligibility
30 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2016 · Synced Oct 2, 2026, 7:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2 for 26 Weeks

NCT02396381
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2, CC
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
30 Years and older
Enrollment
1,039 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
19
States / cities
Tempe, Arizona • Clearwater, Florida • Daytona Beach, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 2, 2026, 7:03 AM EDT