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ClinicalTrials.gov public records Last synced Sep 26, 2026, 5:52 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cigarette Smoking Behavior Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Research and Innovation to Stop E-cigarette/Vaping in Young Adults

NCT04974580
View directory record Official record
Conditions
Nicotine Dependence, E-Cig Use
Interventions
Nicotine patch, Phone Counseling, Digital Coaching
Drug · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 24 Years
Enrollment
508 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

NCT02628964
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
e-cigarettes
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional

Contingency Management and Pharmacotherapy for Smoking Cessation

NCT00683280
View directory record Official record
Conditions
Cigarette Smoking
Interventions
contingency management, Standard of Care
Behavioral · Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional

SmartQuit Program for Smoking Cessation

NCT04510077
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
SmartQuit Smoking and Tobacco Cessation Program, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Sep 26, 2026, 5:52 PM EDT
Recruiting Phase 2 Interventional

The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

NCT07322432
View directory record Official record
Conditions
Addiction Nicotine
Interventions
VapeAway filter system
Device
Lead sponsor
VapeAway
Industry
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Health-Kit Enabled Mobile App for Tobacco Cessation

NCT06292130
View directory record Official record
Conditions
Cigarette Smoking
Interventions
refresh
Behavioral
Lead sponsor
Pro-Change Behavior Systems
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
South Kingstown, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial of Smoking Cessation Mobile Phone Program

NCT02656745
View directory record Official record
Conditions
Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder, Tobacco Dependence
Interventions
Mobile Smoking Cessation Solution
Device
Lead sponsor
Click Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Phase 4 Interventional

Smoking Study With Behavioral Therapy for Hypertensive Patients

NCT00879177
View directory record Official record
Conditions
Cigarette Smoking, Hypertension
Interventions
Varenicline, behavioral therapy
Drug · Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 9, 2017 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult, Closed-System ENDS Consumers

NCT04088175
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
JUUL ENDS - Virginia Tobacco 5% nicotine strength, JUUL ENDS - Virginia Tobacco 3% nicotine strength, JUUL ENDS - Menthol 5% nicotine strength, JUUL ENDS - Menthol 3% nicotine strength, JUUL ENDS - Mint 5% nicotine strength, JUUL ENDS - Mint 3% nicotine strength, JUUL ENDS - Mango 5% nicotine strength, JUUL ENDS - Mango 3% nicotine strength
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Burbank, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Sep 26, 2026, 5:52 PM EDT
Completed No phase listed Observational

Couples Dynamics and Smoking Cessation

NCT03885336
View directory record Official record
Conditions
Smoking, Smoking Cessation, Cessation, Smoking, Smoking Behaviors, Smoking, Cigarette
Interventions
No Interventions
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 26, 2026, 5:52 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Behavioral Application for Improving Smoking Cessation Among Smokers

NCT07493252
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone app-based Intervention (Actify! A app), Smartphone app-based Intervention (Actify! B app), Health Promotion and Education, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,812 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Network Intervention to Prevent Vaping

NCT04678245
View directory record Official record
Conditions
Vaping, Preventive Psychiatry, Social Networking
Interventions
Above the Influence-Vaping (ATI-V)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 18 Years
Enrollment
3,950 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of a Smartphone-Based Switch Program

NCT06544772
View directory record Official record
Conditions
Smoking Cessation
Interventions
Pivot cigarette smoking cessation program
Device
Lead sponsor
Pivot Health Technologies Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Carlos, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

NCT05706701
View directory record Official record
Conditions
Nicotine Vaping
Interventions
Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking and Ventricular Repolarization

NCT03916341
View directory record Official record
Conditions
Sudden Cardiac Death, Prolonged QTc Interval
Interventions
EC with nicotine, EC without nicotine, control, TC with nicotine (own brand), research TC with very low level nicotine
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Methods Project 4: Clinical Trial - Amended

NCT03111537
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cigarettes, E-Cigarette, Nicotine Gum or Lozenge
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional

Testing Methods of Self-persuasion Involving Cigarette Smoking

NCT02069483
View directory record Official record
Conditions
Smoking
Interventions
Motivational Interviewing, Tailored Feedback
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 25, 2014 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Sensitivity to Intravenous Nicotine: Genetic Moderators

NCT00969137
View directory record Official record
Conditions
Nicotine Dependence
Interventions
saline, Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 18, 2017 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional

Effect of Packaging on Smoking Perceptions and Behavior

NCT02676193
View directory record Official record
Conditions
Smoking, Tobacco Smoking
Interventions
Effect of Packaging on Smoking Perceptions and Behavior
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping

NCT07413432
View directory record Official record
Conditions
Cannabis, Vaping, Emotion Regulation
Interventions
Virtual reality videogame intervention for vaping prevention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Phase 4 Interventional Results available

Varenicline Effects In Schizophrenic Smokers

NCT00548470
View directory record Official record
Conditions
Schizophrenia, Tobacco Use Disorder, Nicotine Dependance
Interventions
Varenicline
Drug
Lead sponsor
Nathan Kline Institute for Psychiatric Research
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2

NCT02649556
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2, CC
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
30 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
19
States / cities
Tempe, Arizona • Clearwater, Florida • Daytona Beach, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

GeoScan and Remote Geo Smoking Study: Neural and Behavioral Correlates of Smokers' Exposure to Retail Environments

NCT04279483
View directory record Official record
Conditions
Smoking, Tobacco, Smoking, Smoking, Cigarette
Interventions
Tobacco retailer, Non-tobacco retailer
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
343 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 26, 2026, 5:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Responses to E-cigarette Message Source and Presentation

NCT06274723
View directory record Official record
Conditions
Vaping
Interventions
Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 24 Years
Enrollment
848 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 26, 2026, 5:52 PM EDT