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ClinicalTrials.gov public records Last synced Oct 30, 2026, 4:25 PM EDT

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Showing 625–648 of 690 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cigarette Use Clear all
Completed Not applicable Interventional Results available

Promotion and Mitigation Factors Leading to Illegal Tobacco Purchases

NCT06001840
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Vaping
Interventions
Promotion factors, Mitigation strategies
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 30, 2026, 4:25 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks

NCT05641974
View directory record Official record
Conditions
Smoking, Cigarette Smoking
Interventions
Helpers Stay Quit Training
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
940 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effectiveness of Smoking Cessation Guidelines in the Emergency Department

NCT00756704
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking cessation guideline implementation
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
789 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
2
States / cities
Des Moines, Iowa • Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 4, 2011 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Results available

Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior

NCT04805515
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Nicotine Corrective Messages
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
794 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 2, 2022 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional

Effect of Packaging on Smoking Perceptions and Behavior

NCT02676193
View directory record Official record
Conditions
Smoking, Tobacco Smoking
Interventions
Effect of Packaging on Smoking Perceptions and Behavior
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

UW Quitting Using Intensive Treatment Study (QUITS)

NCT03176784
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Varenicline, Nicotine patch, Placebo Patch, Placebo Pill
Drug · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2023 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services

NCT03743532
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette Switching, Financial Incentives
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD1601: A Study to Evaluate the Exposure to Tar and Nicotine From Two Cigarette Products That Contain a Menthol Capsule in the Filter

NCT04529551
View directory record Official record
Conditions
Smoking, Tobacco Smoking, Tobacco Use
Interventions
1601A, 1601B
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 30, 2026, 4:25 PM EDT
Terminated Not applicable Interventional Results available

tDCS and Cognitive Training Intervention for Chronic Smokers With Schizophrenia

NCT03588728
View directory record Official record
Conditions
Transcranial Direct Current Stimulation, Smoking, Cigarette, Schizophrenia
Interventions
Transcranial Direct Current Stimulation, Cognitive Remediation (CR)
Other · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

NCT02232737
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
775 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Results available

Pain and Smoking Study

NCT02971137
View directory record Official record
Conditions
Smoking, Pain, Smoking Cessation
Interventions
Smoking Cessation plus CBI, Smoking Cessation Standard
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
West Haven, Connecticut • Leeds, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 30, 2026, 4:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction

NCT00264342
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use Disorder
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 70 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 23, 2013 · Synced Oct 30, 2026, 4:25 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

NCT01898169
View directory record Official record
Conditions
Nicotine Dependence
Interventions
NJOY King 26 mg nicotine Electronic Nicotine Delivery System
Other
Lead sponsor
LA Clinical Trials
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2013 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers (AMERIDIAN)

NCT00387946
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation
Interventions
SSR591813L (dianicline)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2012 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

NCT03060083
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT)
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 4, 2022 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 2 Interventional Results available

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

NCT02796651
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease - COPD
Interventions
Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Placebo for formoterol fumarate, Formoterol fumarate (12 μg), Formoterol fumarate (40 μg)
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
40 Years to 130 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
20
States / cities
Glendale, Arizona • Phoenix, Arizona • Tempe, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 30, 2026, 4:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal

NCT02520349
View directory record Official record
Conditions
Nicotine Dependence
Interventions
MarkTen and e-Go e-cigarettes
Device
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Assess the Pharmacokinetics of Oral Nicotine Pouches and Lozenges in Healthy Adults

NCT04755348
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking
Interventions
Product A, Product B, Product C, Product D, Product E, Product F
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
21 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 30, 2021 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette Smoking Among Young Adults

NCT04340947
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Very low nicotine cigarette: menthol, Very low nicotine cigarette: non-mentol
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 34 Years
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 2 Interventional Results available

Adaptive Pharmacotherapy for Smoking Cessation

NCT02501265
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol, Nicotine Adaptive Protocol
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional Results available

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

NCT05932693
View directory record Official record
Conditions
E-Cig Use
Interventions
E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%), E-liquid coolant (WS-3, 1.0%), E-liquid coolant (WS-3, 2.0%), E-liquid coolant (menthol, 0.05%), E-liquid coolant (menthol, 0.1%), E-liquid coolant (menthol, 0.5%), E-liquid coolant (menthol, 1.0%), E-liquid coolant (menthol, 2.0%), E-liquid coolant (WS-23, 0.05%), E-liquid coolant (WS-23, 0.1%), E-liquid coolant (WS-23, 0.5%), E-liquid coolant (WS-23, 1.0%), E-liquid coolant (WS-23, 2.0%), E-liquid coolant (WS-23, 4.0%)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Not applicable Interventional

Cultural Adaptation and Piloting of a Smoking Cessation Intervention for Smokers With HIV

NCT03580460
View directory record Official record
Conditions
Hiv, Cigarette Smoking
Interventions
Computer delivered smoking cessation counseling
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Oct 30, 2026, 4:25 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

NCT00469079
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine gum and lozenge, Taboka, Camel Snus
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 30, 2026, 4:25 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

"Quit Smoking on Your Own" Brief Online Study

NCT02103829
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Brief Intervention #1, Brief Intervention #2, Brief Intervention #3
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years and older
Enrollment
345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 30, 2026, 4:25 PM EDT