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ClinicalTrials.gov public records Last synced Oct 30, 2026, 8:27 PM EDT

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Showing 673–690 of 690 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cigarette Use Clear all
Completed No phase listed Observational

A Comparison of Exhaled Carbon Monoxide Measurements Using the iCOquit Smokerlyzer and Vitalograph Breath CO Monitor vs Carboxyhemoglobin From Venous Samples While Validating a Mobile Research Application

NCT04826549
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Not listed
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Timeline
2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

FDA Cigarette Warning Labels: Eye Tracking Study

NCT04936724
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Pictorial Warning Labels
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Oct 30, 2026, 8:27 PM EDT
Recruiting Not applicable Interventional

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

NCT07711691
View directory record Official record
Conditions
Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
Interventions
Empower LCS, Call+ Telephone Navigation, Usual Care, Education
Behavioral · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
50 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
57
States / cities
Anaheim, California • Costa Mesa, California • Irvine, California + 27 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Phase 4 Interventional Results available

Health Systems Reach Interventions Project

NCT04199117
View directory record Official record
Conditions
Smoking, Cigarette, Smoking Cessation
Interventions
Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment, Automated tailored outreach, Care management, Wisconsin Tobacco Quit Line referral, Primary care provider referral, Untailored outreach, Multiple smoking cessation coaching calls
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 30, 2026, 8:27 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

NCT06535867
View directory record Official record
Conditions
Smoking, Smoking, Cigarette, Smoking, Tobacco, Betel Chewer's Mucosa, Tobacco Use, Tobacco Smoking, Alcohol Drinking, Smokeless Tobacco Hyperkeratosis
Interventions
mHealth
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
5,122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

United States Pre-Market Tobacco Application Pharmacokinetics

NCT03719391
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
Interventions
Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS, Creme Brulee flavored JUUL 5% ENDS, VUSE Solo e-cigarette, Nicorette White Ice Mint 4mg nicotine polacrilex gum, Usual Brand combustible cigarette
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of E-cigarette Device Warnings

NCT05714982
View directory record Official record
Conditions
Vaping Behaviors
Interventions
Label with text health warning, Label with pictorial health warning, Label with neutral statements about vaping
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,369 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarette Use on the Lungs

NCT02596685
View directory record Official record
Conditions
Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions
Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Phase 2 Interventional Results available

Meclizine as a Potential Smoking Cessation Treatment

NCT01443858
View directory record Official record
Conditions
Smoking Cessation
Interventions
Meclizine, Nicotine Patch, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2014 · Synced Oct 30, 2026, 8:27 PM EDT
Recruiting Not applicable Interventional

Parents Helping Parents for Youth Vaping Cessation

NCT07207850
View directory record Official record
Conditions
Implementation Science, Engagement, Patient, E Cigarette Use, Peer Support, Vaping Teens, Vaping Cessation, Parent Support
Interventions
Parents Helping Parents program
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
15 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional

An Interprofessional Intervention to Reduce Smoking Rates

NCT03380910
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Pharmacy and Behavioral Health Team, Motivational Interviewing
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Henrico, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Abuse Liability Among African American and White Smokers

NCT04646668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette and Heat not burn
Combination Product
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 30, 2026, 8:27 PM EDT
Terminated Not applicable Interventional Results available

Intermittent Theta Burst for the Treatment of Alcohol Use Disorders in Veterans

NCT03291431
View directory record Official record
Conditions
Alcohol Use Disorder, Depressive Disorder, Cigarette Smoking
Interventions
Intermittent theta burst transcranial magnetic stimulation
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes

NCT02210754
View directory record Official record
Conditions
Smoking
Interventions
blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle), Marlboro Cigarette
Other
Lead sponsor
Lorillard Tobacco Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 7, 2014 · Synced Oct 30, 2026, 8:27 PM EDT
Not yet recruiting Not applicable Interventional

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

NCT06965296
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
14 Years to 20 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 30, 2026, 8:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Using Computers to Assist in Parental Smoking Cessation in a Pediatric Setting

NCT01334216
View directory record Official record
Conditions
Cigarette Smoking
Interventions
CHICA Smoking Cessation Module, CHICA Placebo
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
362 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Oct 30, 2026, 8:27 PM EDT