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ClinicalTrials.gov public records Last synced Oct 25, 2026, 11:38 PM EDT

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Showing 1–24 of 258 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Circadian Rhythm Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Self-Care for Dementia Caregivers

NCT05309577
View directory record Official record
Conditions
Aging, Mental Disorder, Eating, Healthy, Physical Inactivity, Prodromal Symptoms, Sleep, Alzheimer Disease, Dementia, Circadian Rhythm Disorders
Interventions
Behavioral Self-Monitoring + Motivational Interviewing
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sleep, Circadian Rhythm & Skin Health

NCT02457000
View directory record Official record
Conditions
Healthy, Psoriasis, Eczema, Acne
Interventions
Not listed
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 15, 2021 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Results available

Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors

NCT02954809
View directory record Official record
Conditions
Fatigue, Sleep Disturbance, Circadian Dysregulation
Interventions
Morning bright light therapy, Dim light
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 25, 2026, 11:38 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Chronic Sleep Restriction in Young and Older People

NCT00506428
View directory record Official record
Conditions
Aging, Sleep Deprivation, Metabolic Syndrome
Interventions
chronic sleep restriction
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2009 · Synced Oct 25, 2026, 11:38 PM EDT
Terminated Not applicable Interventional Results available

Blind Child Melatonin Treatment Study

NCT00691444
View directory record Official record
Conditions
Blindness
Interventions
Melatonin, Melatonin
Dietary Supplement · Biological
Lead sponsor
Oregon Health and Science University
Other
Eligibility
5 Years to 20 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

NCT03464084
View directory record Official record
Conditions
Glucose, Circadian Rhythm, Melatonin, Genes, Light
Interventions
placebo, melatonin, bright light, dim light
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Oct 25, 2026, 11:38 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Biomarkers for Circadian Timing in Healthy Adults

NCT03956745
View directory record Official record
Conditions
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS), Advanced Sleep Phase Syndrome, Advanced Sleep Phase, Delayed Sleep Phase, Delayed Sleep Phase Syndrome, Non-24 Hour Sleep-Wake Disorder, Irregular Sleep-Wake Syndrome, Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Delayed Phase Sleep Syndrome
Interventions
sleep-wake timing, constant routine
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Melatonin on Insomnia Symptoms in Older Adults

NCT00230737
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
Melatonin 0.4 mg, Melatonin 4.0 mg, Placebo
Drug
Lead sponsor
Nalaka Gooneratne
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 8, 2017 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Teen Sleep Health Study

NCT04087603
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm, Adolescent Behavior
Interventions
Weekend Morning Bright Light & Early Bedtime
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
14 Years to 17 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Oct 25, 2026, 11:38 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

NCT06104280
View directory record Official record
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test, Ecological Momentary Assessments, Actigraphy, DLMO, Melatonin Suppression Test
Other · Behavioral · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Timing of Meals for Weight Loss

NCT02204735
View directory record Official record
Conditions
Overweight, Obesity, Weight Loss
Interventions
Eat majority of calories in the morning, Eat the majority of calories in the evening
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
25 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 25, 2026, 11:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Circadian Rhythms in Human Adipose

NCT06891534
View directory record Official record
Conditions
Obesity, Abdominal, Feeding Patterns
Interventions
Continuous Feeding, Intermittent feeding
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Bright Light Treatment On Elders In a Long Term Care Environment

NCT01042587
View directory record Official record
Conditions
Behavioral Responses to Bright Light Therapy in Elders
Interventions
exposure to bright light, low luminosity red light
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
65 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Elizabethtown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2010 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Circadian Rhythms of Aqueous Humor Dynamics in Humans

NCT00572936
View directory record Official record
Conditions
Glaucoma
Interventions
Latanoprost, Dorzolamide, Timolol
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Phase 3 Interventional Results available

Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder

NCT01430754
View directory record Official record
Conditions
Non-24-Hour Sleep-Wake Disorder
Interventions
tasimelteon, Placebo
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
22
States / cities
Phoenix, Arizona • Orange, California • Palo Alto, California + 19 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2014 · Synced Oct 25, 2026, 11:38 PM EDT
Recruiting Not applicable Interventional

Healthy Lifestyles in Bipolar Disorder: Bay Area Study

NCT06555406
View directory record Official record
Conditions
Bipolar Disorder, Time Restricted Eating
Interventions
Time-restricted eating for 8 weeks
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional

Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients

NCT03684460
View directory record Official record
Conditions
Circadian Rhythm Disorders
Interventions
Daytime Bright Light, Usual Light
Device
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 25, 2026, 11:38 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders

NCT00387179
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Methylxanthine, Light Therapy
Drug · Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 25, 2009 · Synced Oct 25, 2026, 11:38 PM EDT
Not listed No phase listed Observational

Observational Study to Investigate the Melatonin and Cortisol Circadian Rhythms of Individuals With Smith-Magenis Syndrome (SMS)

NCT02180451
View directory record Official record
Conditions
Smith Magenis Syndrome
Interventions
Not listed
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
6 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 25, 2016 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Light Treatment During Sleep on Young Men

NCT00796939
View directory record Official record
Conditions
Depression
Interventions
Green light mask, Red Light Mask
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2015 · Synced Oct 25, 2026, 11:38 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Eating Behaviors in Shift Workers

NCT04468672
View directory record Official record
Conditions
Shift Work Type Circadian Rhythm Sleep Disorder, Eating Behavior
Interventions
Portion size
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
20 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Healthy Heroes Study

NCT03533023
View directory record Official record
Conditions
Shift Workers' Health, Time Restricted Eating, Fasting
Interventions
Time Restricted Eating + Standard of Care, Standard of Care
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 25, 2026, 11:38 PM EDT
Active, not recruiting No phase listed Observational

Circadian Rhythm Disruption in the Hospital Intensive Care Environment

NCT05828680
View directory record Official record
Conditions
Surgery, Cardiovascular Diseases
Interventions
Observation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Timeline
2023 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 25, 2026, 11:38 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts

NCT06100809
View directory record Official record
Conditions
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Interventions
Personalized coaching, Nutrition handout
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 25, 2026, 11:38 PM EDT