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ClinicalTrials.gov public records Last synced Oct 7, 2026, 10:46 AM EDT

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Showing 97–120 of 259 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Circadian Rhythm Clear all
Completed Not applicable Interventional Results available

Sleep and Circadian Rhythms in Mechanically Ventilated Patients

NCT01276652
View directory record Official record
Conditions
Respiratory Failure, Critical Illness
Interventions
Environmental modification
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 26, 2017 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Not applicable Interventional

Pupillometry in Delayed Sleep Wake Phase Disorder

NCT06949644
View directory record Official record
Conditions
Delayed Sleep-Wake Phase Disorder
Interventions
Light and Citalopram
Combination Product
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep

NCT01586039
View directory record Official record
Conditions
Non-visual Photoreception
Interventions
Visible light
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2021 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Timed Exercise Study

NCT04097886
View directory record Official record
Conditions
Circadian Timing - Exercise
Interventions
Morning Exercise, Evening Exercise
Other
Lead sponsor
Julie Pendergast
Other
Eligibility
18 Years to 45 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 20, 2019 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skeletal Response to Simulated Night Shift

NCT05074277
View directory record Official record
Conditions
Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Interventions
Simulated short term night shift work schedule
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Not applicable Interventional

Healthy Lifestyles for Bipolar Disorder

NCT06188754
View directory record Official record
Conditions
Time Restricted Eating, Diet, Mediterranean
Interventions
Time restricted eating, Mediterranean diet
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Facilitating Adjustment to Simulated Jet Lag

NCT05382923
View directory record Official record
Conditions
Circadian Rhythm Sleep Disorder, Jet Lag Type
Interventions
Bright Light, Bright Light + Exercise + Melatonin, Control
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 45 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 19, 2022 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Not applicable Interventional

Use of Circadian Reset Technology to Alter REM Sleep and Appetitive Control in Patients With Binge Eating Disorder

NCT06858774
View directory record Official record
Conditions
Binge-Eating Disorder
Interventions
Circadian Reset Technology, VR Headset
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Phase 2 Interventional

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

NCT06226025
View directory record Official record
Conditions
Bipolar Disorder, Delayed Sleep-Wake Phase Disorder
Interventions
Melatonin, Placebo, Behavioral sleep intervention, Behavioral sleep control
Drug · Other · Behavioral
Lead sponsor
Leslie Swanson
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Melatonin Levels in Smith Magenis Syndrome (SMS)

NCT00691574
View directory record Official record
Conditions
Chromosome Disorders
Interventions
Melatonin, Enviro-light artificial light box
Dietary Supplement · Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
3 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2009
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional

Limiting Trunk Flexion as a Self-treatment for Low Back Pain

NCT01830751
View directory record Official record
Conditions
Low Back Pain
Interventions
Restrained Sitting Treatment
Other
Lead sponsor
Liberty Mutual Research Institute for Safety
Industry
Eligibility
30 Years to 60 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Hopkinton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks

NCT03934255
View directory record Official record
Conditions
Circadian Rhythm, Blood Pressure
Interventions
Constant Routine Protocol
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 7, 2026, 10:46 AM EDT
Active, not recruiting No phase listed Observational

Circadian Rhythm Disruption in the Hospital Intensive Care Environment

NCT05828680
View directory record Official record
Conditions
Surgery, Cardiovascular Diseases
Interventions
Observation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Timeline
2023 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Phase 3 Interventional

Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

NCT06568367
View directory record Official record
Conditions
Excessive Sleepiness, Shift-work Disorder
Interventions
Solriamfetol 150 mg, Solriamfetol 300 mg, Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
44
States / cities
Auburn, Alabama • Cullman, Alabama • Chandler, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Withdrawn Not applicable Interventional

Sleep and Circadian Rhythm Study in Head and Neck Cancer Patients

NCT05099952
View directory record Official record
Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
Biospecimen Collection, Counseling, Educational Intervention, Electronic Health Record Review, Medical Device Usage and Evaluation, Questionnaire Administration
Procedure · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Oct 7, 2026, 10:46 AM EDT
Recruiting Not applicable Interventional

Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction

NCT06678880
View directory record Official record
Conditions
Depression, Depression During the Menopausal Transition, Menopausal Depression
Interventions
Phase Advanced Intervention (PAI), Phase Delay Intervention (PDI)
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
45 Years to 75 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Not listed No phase listed Observational

Observational Study to Investigate the Melatonin and Cortisol Circadian Rhythms of Individuals With Smith-Magenis Syndrome (SMS)

NCT02180451
View directory record Official record
Conditions
Smith Magenis Syndrome
Interventions
Not listed
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
6 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 25, 2016 · Synced Oct 7, 2026, 10:46 AM EDT
Completed No phase listed Observational

Impact of Night Shift Work on 24-hour Blood Glucose Levels

NCT05559762
View directory record Official record
Conditions
Circadian Rhythm; Inversion, Metabolic Disease
Interventions
Not listed
Lead sponsor
Lincoln Memorial University
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Oct 7, 2026, 10:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Identification of Novel Circadian Biomarkers

NCT02291003
View directory record Official record
Conditions
Circadian Rhythm Disorders
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep Duration Required to Restore Performance During Chronic Sleep Restriction

NCT01581125
View directory record Official record
Conditions
Sleep, Sleep Deprivation, Insufficient Sleep Syndrome
Interventions
Sleep:wake 1, Sleep:wake 2
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2016 · Synced Oct 7, 2026, 10:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Improving Metabolic & Mental Health in Female Healthcare Shift Workers

NCT06158204
View directory record Official record
Conditions
Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
Interventions
Lifestyle Intervention
Behavioral
Lead sponsor
Auburn University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 7, 2026, 10:46 AM EDT
Completed Not applicable Interventional

Time to Move in Pregnancy Hyperglycemia

NCT06125704
View directory record Official record
Conditions
GDM, Physical Activity, Hyperglycemia, Glucose Intolerance, Circadian Rhythm, Exercise
Interventions
Moderate intensity walking or stepping
Behavioral
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Real-World Use of an iPad-Based Light Therapy App, With Optional Biomarker Collection

NCT07744711
View directory record Official record
Conditions
Circadian Rhythms
Interventions
Circadian OS iPad-based light app
Device
Lead sponsor
Circadian OS, Inc
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 7, 2026, 10:46 AM EDT
Completed No phase listed Observational

Sleep & Postoperative Delirium in Hispanic/ Latino Patients After Cardiothoracic Surgery

NCT04786899
View directory record Official record
Conditions
Delirium in Old Age, Sleep Disturbance, Circadian Rhythm Sleep Disorder
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 29, 2022 · Synced Oct 7, 2026, 10:46 AM EDT