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ClinicalTrials.gov public records Last synced Oct 22, 2026, 3:35 AM EDT

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Showing 97–120 of 258 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Circadian Rhythms Clear all
Recruiting Not applicable Interventional

Pupillometry in Delayed Sleep Wake Phase Disorder

NCT06949644
View directory record Official record
Conditions
Delayed Sleep-Wake Phase Disorder
Interventions
Light and Citalopram
Combination Product
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional

Limiting Trunk Flexion as a Self-treatment for Low Back Pain

NCT01830751
View directory record Official record
Conditions
Low Back Pain
Interventions
Restrained Sitting Treatment
Other
Lead sponsor
Liberty Mutual Research Institute for Safety
Industry
Eligibility
30 Years to 60 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Hopkinton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Oct 22, 2026, 3:35 AM EDT
Recruiting No phase listed Observational

Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients

NCT07856641
View directory record Official record
Conditions
Circadian Variation in Anti-Factor Xa (Anti-FXa) Activity
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Timed Exercise Study

NCT04097886
View directory record Official record
Conditions
Circadian Timing - Exercise
Interventions
Morning Exercise, Evening Exercise
Other
Lead sponsor
Julie Pendergast
Other
Eligibility
18 Years to 45 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 20, 2019 · Synced Oct 22, 2026, 3:35 AM EDT
Recruiting Not applicable Interventional

Early Time-Restricted Eating in Older Adults With Hypertension

NCT07135505
View directory record Official record
Conditions
Hypertension, Eating Behaviors
Interventions
Early time-restricted eating
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Withdrawn Not applicable Interventional

Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon

NCT00907595
View directory record Official record
Conditions
Huntington's Disease, Parkinson's Disease, Dementia With Lewy Bodies, Sleep Disorders, Circadian Dysregulation
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 6, 2012 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional

Effects of Sleep, Fatigue, and Timing of Post-dates Inductions Among Nulliparas

NCT01542151
View directory record Official record
Conditions
Pregnancy, Prolonged
Interventions
Time of labor induction
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Phase 3 Interventional Results available

The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder

NCT03715465
View directory record Official record
Conditions
Delayed Sleep Phase Syndrome
Interventions
Melatonin 0.5 MG, Dim Light Melatonin Onset (salivary)
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 25, 2022 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Results available

Feasibility Pilot of Bright Light in the Intensive Care Unit

NCT03568045
View directory record Official record
Conditions
Circadian Rhythm Sleep Disorder, Unspecified
Interventions
standard light, 10,000 lux bright light, 4 hours, 10,000 lux bright light, 8 hours
Device
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Oct 22, 2026, 3:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Circadian Time Restricted Eating

NCT05628012
View directory record Official record
Conditions
Circadian Rhythm, Cardiometabolic Health, Weight Loss, Cardiovascular Health, Time Restricted Feeding
Interventions
Circadian Based Time Restricted Eating
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 3, 2024 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Methodology Issues in a Tailored Light Treatment for Persons With Dementia

NCT01816152
View directory record Official record
Conditions
Sleep Disturbances, Depression
Interventions
High Active intervention, Inactive intervention, Mid Level Active Intervention
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
Albany, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Phase 1 Interventional

Sleep Enhancement Training Study for Novice Shiftworkers

NCT00786266
View directory record Official record
Conditions
Shift-Work Sleep Disorder
Interventions
Sleep Enhancement Training System, NIOSH shiftwork booklet
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism

NCT04414644
View directory record Official record
Conditions
Obesity
Interventions
Eating Condition
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 45 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fire Fighter Fatigue Management Program: Operation Fight Fatigue

NCT01672502
View directory record Official record
Conditions
Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea, Impaired Driving
Interventions
Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
620 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Oct 22, 2026, 3:35 AM EDT
Terminated Not applicable Interventional Results available

Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

NCT03879044
View directory record Official record
Conditions
Shift-Work Sleep Disorder
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep and Circadian Mechanisms of Non-dipping Blood Pressure

NCT03558893
View directory record Official record
Conditions
Hypertension, Cardiovascular Risk Factor
Interventions
Forced Desynchrony
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
30 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional

Clinical Trials of Two Non-drug Treatments for Chronic Depression

NCT00006172
View directory record Official record
Conditions
Mood Disorders, Depressive Disorders, Depression, Chronic Depression
Interventions
Bright light box, High-output negative ion generator, Low-output negative ion generator
Device
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
2
States / cities
Middletown, Connecticut • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2014 · Synced Oct 22, 2026, 3:35 AM EDT
Active, not recruiting No phase listed Observational

Circadian Rhythm Disruption in the Hospital Intensive Care Environment

NCT05828680
View directory record Official record
Conditions
Surgery, Cardiovascular Diseases
Interventions
Observation
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Timeline
2023 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Impact of Overnight Active Temperature Regulation on Gut Microbiome, Inflammation, and Circadian Rhythm.

NCT07848594
View directory record Official record
Conditions
Poor Sleep Quality, Gut Microbiome, Gut Health, Inflammation, Circadian Rhythm, Circadian Clocks, Gut Microbiota, Women's Health, Gut-Brain Axis, Blood Pressure, Systemic Inflammatory Response
Interventions
Overnight Active Temperature Regulation: Eight Sleep Pod System
Device
Lead sponsor
Eight Sleep Inc.
Industry
Eligibility
45 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Newton Center, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tech4Rest Trial With Team Truck Drivers

NCT03108599
View directory record Official record
Conditions
Sleep, Sleep Disturbance, Sleep Disorder, Shift Work, Health Knowledge, Attitudes, Practice, Health Behavior, Fatigue, Vibration; Exposure
Interventions
Enhanced Cab, Fit4Sleep
Other · Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Oct 22, 2026, 3:35 AM EDT
Recruiting Not applicable Interventional

Mind After Midnight

NCT07438912
View directory record Official record
Conditions
Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
Interventions
Sleep Pressure Manipulation
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Early Phase 1 Interventional

Biological Clock Dysfunction in Optic Nerve Hypoplasia

NCT00825591
View directory record Official record
Conditions
Biological Clock Dysfunction, Optic Nerve Hypoplasia
Interventions
Melatonin, Placebo Comparator
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
2 Years to 10 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 22, 2026, 3:35 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Sleep and Circadian Contributions to Nighttime Blood Pressure

NCT05656768
View directory record Official record
Conditions
Sleep, Circadian Rhythm, Blood Pressure, Hypertension
Interventions
Constant Routine Protocol
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
1,427 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 22, 2026, 3:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease

NCT01742182
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Light exposure
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
55 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 22, 2026, 3:35 AM EDT