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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Circulatory Shock Clear all
Completed No phase listed Observational

Inflammation and the Host Response to Injury (Burns)

NCT00257244
View directory record Official record
Conditions
Trauma, Burns, Multiple Organ Failure
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2018
U.S. locations
4
States / cities
Maywood, Illinois • Dallas, Texas • Galveston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jul 23, 2026, 5:01 PM EDT
Active, not recruiting Not applicable Interventional

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

NCT05405426
View directory record Official record
Conditions
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
Interventions
Red blood cell transfusion
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
0 Days to 6 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Not applicable Interventional Results available

Hemodynamic Instability Index: The Impact to Care With a New Predictive Indicator

NCT02185521
View directory record Official record
Conditions
Shock, Hemodynamic Instability
Interventions
patient assessment
Other
Lead sponsor
Philips Healthcare
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
2
States / cities
St Louis, Missouri • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Jul 23, 2026, 5:01 PM EDT
Recruiting No phase listed Observational

Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR

NCT07309029
View directory record Official record
Conditions
Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
Interventions
Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
Device
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Detroit, Michigan • Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Not listed No phase listed Observational

Echocardiography in Septic Shock

NCT02135796
View directory record Official record
Conditions
Septic Shock, Severe Sepsis
Interventions
Echocardiography
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
13 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2019
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jun 12, 2019 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational Results available

Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming

NCT00856349
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Therapy Programming Report (TPR)
Behavioral
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
Not listed
Enrollment
4,384 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
83
States / cities
Anniston, Alabama • Phoenix, Arizona • Tucson, Arizona + 80 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2014 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Not applicable Interventional Results available

Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT)

NCT01128413
View directory record Official record
Conditions
Shock
Interventions
Cheetah NICOM® PLRT, USCOM ® (Ultrasound Cardiac Output Monitor), Inferior Vena Cava (IVC) Ultrasound Collapsibility, CURVES Questionnaire, Lactate Clearance, 500ml Normal Saline Bolus, Clinician Discretion Intravenous Fluid Management
Device · Behavioral · Biological
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 3 Interventional Results available

Study of Efficacy and Safety of Canakinumab Treatment for CRS in Participants With COVID-19-induced Pneumonia

NCT04362813
View directory record Official record
Conditions
Cytokine Release Syndrome (CRS) in Patients With COVID-19-induced Pneumonia
Interventions
Canakinumab, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
15
States / cities
Birmingham, Alabama • Glendale, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Jul 23, 2026, 5:01 PM EDT
No Longer Available No phase listed Expanded access

Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19

NCT04352985
View directory record Official record
Conditions
Septic Shock, Endotoxemia, COVID, Corona Virus Infection, Sepsis, Severe
Interventions
Toraymyxin PMX-20R (PMX Cartridge)
Device
Lead sponsor
Spectral Diagnostics (US) Inc.
Industry
Eligibility
18 Years and older
U.S. locations
3
States / cities
Farmington, Connecticut • Washington D.C., District of Columbia • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2021 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational

Carolinas Cardiogenic Shock Initiative

NCT04985708
View directory record Official record
Conditions
Cardiogenic Shock, Acute; Myocardial Infarction, Complications
Interventions
data collection of clinically available procedures
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2022 · Synced Jul 23, 2026, 5:01 PM EDT
Recruiting No phase listed Observational

Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

NCT05426083
View directory record Official record
Conditions
Acute Coronary Syndrome, Cardiogenic Shock
Interventions
Physiological Assessment
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Not applicable Interventional Results available

Efficacy of Flomax to Improve Stone Passage Following Shock Wave Lithotripsy

NCT00209131
View directory record Official record
Conditions
Urolithiasis
Interventions
Flomax, Sugar pill
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2013 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Not applicable Interventional

Targeting Abdominal Perfusion Pressure in Septic Shock

NCT03582046
View directory record Official record
Conditions
Acute Kidney Injury, Septic Shock, Resuscitations
Interventions
Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
Device
Lead sponsor
Potrero Medical
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Little Rock, Arkansas • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional

Echo vs. EGDT in Severe Sepsis and Septic Shock

NCT02354742
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Echo guided fluid resuscitation, EGDT fluid resuscitation
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Jul 15, 2018 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated No phase listed Observational

The Use of Tissue Oxygen Monitoring in Critically Injured Patients

NCT00328341
View directory record Official record
Conditions
Traumatic Brain Injury, Hemorrhagic Shock, Trauma
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2013 · Synced Jul 23, 2026, 5:01 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Using Fluorescence Angiography to Detect Occult Shock

NCT02846727
View directory record Official record
Conditions
Hypoperfusion
Interventions
skin perfusion image
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Jul 23, 2026, 5:01 PM EDT
Recruiting No phase listed Observational

Cardiogenic Shock Working Group Registry

NCT04682483
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Vasopressor, Inotrope, Acute Mechanical Circulatory Support Devices
Drug · Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
16
States / cities
Weston, Florida • Chicago, Illinois • Portland, Maine + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low Intensity Extracorporeal Shock Wave Therapy (Li-ESWT) for Erectile Dysfunction

NCT04720755
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Low-Intensity Extracorporeal Shock Wave Therapy
Device
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
40 Years to 80 Years · Male only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational

Near Patient Molecular Testing in Sepsis

NCT05469048
View directory record Official record
Conditions
Sepsis, Systemic Inflammatory Response Syndrome
Interventions
Not listed
Lead sponsor
Immunexpress
Industry
Eligibility
18 Years to 95 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Los Angeles, California • Atlanta, Georgia • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 3 Interventional Results available

Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis

NCT00608322
View directory record Official record
Conditions
Sepsis
Interventions
Inhaled nitric oxide, Sham inhaled nitric oxide
Drug · Other
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
14 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study of HBV-001 D1 in Healthy Adults

NCT00936429
View directory record Official record
Conditions
Dengue Fever
Interventions
DEN1-80E (HBV-001 D1 + 3.5 mg Alhydrogel), Placebo for DEN1-80E
Biological
Lead sponsor
Hawaii Biotech, Inc.
Industry
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 6, 2011 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Phase 2 Interventional Results available

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

NCT02974257
View directory record Official record
Conditions
Cardiac Arrest, Shock, Lactic Acidosis, Thiamin Deficiency
Interventions
Thiamine, placebo
Drug · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 4 Interventional Results available

Effect of Nebulized Bronchodilators on Heart Rate

NCT01151579
View directory record Official record
Conditions
COPD, Sepsis, Shock
Interventions
Levalbuterol, Albuterol
Drug
Lead sponsor
Fahim Khorfan, MD
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 22, 2015 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet During Simple & Complex Mobility Activities

NCT01404559
View directory record Official record
Conditions
Amputation
Interventions
Ossur Variflex prosthetic foot, Ossur Ceterus prosthetic foot, Endolite Elite Blade prosthetic foot
Device
Lead sponsor
University of South Florida
Other
Eligibility
21 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 14, 2014 · Synced Jul 23, 2026, 5:01 PM EDT