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Showing 1–24 of 458 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Closed Head Injury Clear all
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Dynamic Vision Between College Athletes & Controls

NCT05819489
View directory record Official record
Conditions
Concussion, Brain, Dynamic Vision Tests
Interventions
Dynamic Vision Testing
Diagnostic Test
Lead sponsor
California State University, Northridge
Other
Eligibility
Up to 30 Years
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Not applicable Interventional

Effect of Early Rest on Recovery From Pediatric Concussion

NCT01101724
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
Interventions
Mandated Rest, Intervention
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
11 Years to 22 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 4, 2013 · Synced Sep 9, 2026, 7:24 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Effects of Multiple Concussions in Retired NHL Players

NCT02746523
View directory record Official record
Conditions
Cognitive Deficits, Proprioceptive Disorders
Interventions
Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS), Depression Scale, Cognitive Assessment
Other · Genetic
Lead sponsor
New York Institute of Technology
Other
Eligibility
40 Years to 80 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Field Implementation of iDETECT

NCT02529618
View directory record Official record
Conditions
Concussion, Brain Trauma
Interventions
integrated Display Enhanced Testing for Cognitive Impairment and mild traumatic brain injury (iDETECT), Riddell High Impact Technology (HIT) System, i1 Biometrics Vector Mouth Guard
Device
Lead sponsor
Emory University
Other
Eligibility
14 Years and older
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
4
States / cities
Atlanta, Georgia • College Park, Georgia • Marietta, Georgia + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Sep 9, 2026, 7:24 AM EDT
Active, not recruiting Phase 2 Interventional

Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury

NCT02849223
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Anodal Transcranial Direct Current Stimulation, Sham stimulation
Device
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational

Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes

NCT02957461
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate
Interventions
BrainScope Ahead 200iD
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 25 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
8
States / cities
Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

NCT02266329
View directory record Official record
Conditions
Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache, Mild Traumatic Brain Injury, Posttraumatic Migraine
Interventions
prazosin hydrochloride, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

How do the Neck Muscles Influence Head Acceleration During Sport-associated Impact Events in High School Athletes?

NCT03883165
View directory record Official record
Conditions
Sport-related Concussion, Brain Concussion, Healthy
Interventions
high-intensity neck strengthening, Control group
Other
Lead sponsor
University of Michigan
Other
Eligibility
13 Years to 19 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 23, 2025 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Concussion Testing: A Novel Non-invasive Concussion Detection Device

NCT02370914
View directory record Official record
Conditions
Concussion
Interventions
Nautilus NeuroWaveTM System, SCAT
Device · Behavioral
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
14 Years to 18 Years · Male only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Los Altos, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Not applicable Interventional

One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles

NCT04099329
View directory record Official record
Conditions
Concussion, Brain
Interventions
Pre-game Safety Huddles
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 14 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 30, 2022 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Usability and Tolerability of Novel Protection Device Against Potential Brain Injury During Competitive Sport

NCT03318822
View directory record Official record
Conditions
Brain Injuries, Traumatic, Brain Injury Traumatic Mild
Interventions
Q-Collar
Device
Lead sponsor
Emory University
Other
Eligibility
14 Years to 49 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Sep 9, 2026, 7:24 AM EDT
Withdrawn Not applicable Interventional

Attention Intervention Management

NCT01779427
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Attention Deficit Hyperactivity Disorder (ADHD), Head Injury, Brain Concussion, Head Injuries, Closed
Interventions
AIM
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Not applicable Interventional Results available

Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium

NCT01483937
View directory record Official record
Conditions
Vestibular Diseases, Labyrinth Diseases, Ear Diseases, Otorhinolaryngologic Diseases, Traumatic Brain Injury
Interventions
Usual care physical therapy plus SEMD, Usual care physical therapy only
Device · Other
Lead sponsor
Karen L Atkins
Industry
Eligibility
21 Years to 84 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Garden Grove, California • Celebration, Florida • Fort Myers, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2014 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational

Use of Eye Movement Tracking to Detect Oculomotor Abnormality in Traumatic Brain Injury Patients

NCT02776462
View directory record Official record
Conditions
Brain Concussion, Cerebral Concussion, Concussion, Intermediate, Concussion, Mild, Concussion, Severe, Trauma, Nervous System, Craniocerebral Trauma, Brain Injuries
Interventions
EyeBox CNS
Device
Lead sponsor
Oculogica, Inc.
Industry
Eligibility
5 Years to 67 Years
Enrollment
321 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Lone Tree, Colorado • Beaver Dam, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Sep 9, 2026, 7:24 AM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

NCT00983437
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Armodafinil
Drug
Lead sponsor
Cephalon, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
61
States / cities
Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 49 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Sep 9, 2026, 7:24 AM EDT
Recruiting Phase 2 Interventional

Magnesium and Riboflavin Treatment for Post-Concussion Headache

NCT06260072
View directory record Official record
Conditions
Concussion, Intermediate
Interventions
magnesium and riboflavin supplement
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 40 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2025 · Synced Sep 9, 2026, 7:24 AM EDT
Enrolling by invitation Not applicable Interventional

SMART-CPT for PTSD/Concussion Implementation

NCT06995612
View directory record Official record
Conditions
PTSD, Concussion, Mild
Interventions
SMART-CPT, CPT
Behavioral
Lead sponsor
San Diego Veterans Healthcare System
Federal
Eligibility
18 Years to 55 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 9, 2026, 7:24 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development

NCT02519998
View directory record Official record
Conditions
Brain Concussion
Interventions
Concussion
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
10 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 10, 2015 · Synced Sep 9, 2026, 7:24 AM EDT
Recruiting Phase 1Phase 2 Interventional

Modulating Exercise Dosage to Improve Concussion Recovery

NCT05434130
View directory record Official record
Conditions
Concussion, Brain, Treatment, Aerobic Exercise, Inflammation, Depression, Anxiety
Interventions
High Dose Exercise
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years to 18 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Aurora, Colorado • Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 9, 2026, 7:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Assess the Effectiveness of the Nautilus BrainPulse™ as an Aid in the Diagnosis of Concussion

NCT02660164
View directory record Official record
Conditions
Concussion
Interventions
Nautilus BrainPulse Recording
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
10 Years to 25 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
4
States / cities
Fort Lauderdale, Florida • Munster, Indiana • Baton Rouge, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2022 · Synced Sep 9, 2026, 7:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Protection Against Potential Brain Injury During Competitive Football

NCT02696200
View directory record Official record
Conditions
Concussion
Interventions
Q Collar
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
14 Years to 19 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Sep 9, 2026, 7:24 AM EDT
Recruiting Phase 2 Interventional

Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI

NCT05049057
View directory record Official record
Conditions
Posttraumatic Headache, Mild Traumatic Brain Injury
Interventions
Erenumab 140 Mg/mL Subcutaneous Solution, Placebo
Drug
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
4
States / cities
Fort Bragg, North Carolina • Pittsburgh, Pennsylvania • El Paso, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Sep 9, 2026, 7:24 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury

NCT07327567
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk, Suicide Risk Factor
Interventions
Crisis Response Planning
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 9, 2026, 7:24 AM EDT
Recruiting Not applicable Interventional

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

NCT04978571
View directory record Official record
Conditions
Post-Concussion Syndrome, COVID Long-Haul, COVID-19
Interventions
percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (sham device), percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
Device
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
11 Years to 18 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 9, 2026, 7:24 AM EDT