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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Closure Technique Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Fascial Closure Technique After Gynecologic Laparoscopic Surgery and Postoperative Pain

NCT04765306
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Traditional Direct Fascial Closure, Fascial Closure Device
Device
Lead sponsor
Jessica G Putman
Other
Eligibility
18 Years and older · Female only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional Results available

Comparison of Two Methods of Negative Pressure Wound Therapy

NCT00724750
View directory record Official record
Conditions
Acute Wounds From Trauma, Dehiscence or Surgical Complications
Interventions
Gauze suction (G-SUC), Vacuum Assisted Closure Device (VAC)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 18, 2015 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Phase 4 Interventional Results available

PleuraSeal Post Market Study (Europe)

NCT00704171
View directory record Official record
Conditions
Lung Disease, Pulmonary Lobectomy
Interventions
Standard Tissue Closure Techniques, PleuraSeal Lung Sealant System
Procedure · Device
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Sep 4, 2026, 7:52 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Hip DAA Closure Techniques

NCT06006572
View directory record Official record
Conditions
Total Hip Replacement, Wound Complication
Interventions
wound closure subcuticular running stitch using 3-0 monocryl suture without skin adhesive, wound closure subcuticular running stitch using 3-0 monocryl suture with two layers of skin adhesive
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional Results available

This Study Will Evaluate the Safety and Potential Complications of Dual ProGlide vs Single ProGlide and Angioseal for Common Femoral Arteriotomy Closure Following Transcatheter Aortic Valve Replacement

NCT06983938
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement, Closure Technique
Interventions
Double Perclose Proglide, Single Perclose Proglide plus Angioseal
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional

Thoracotomy Closure Technique and Postoperative Pain Study: A Randomized Controlled Trial

NCT02063438
View directory record Official record
Conditions
Hernia, Lung Cancer
Interventions
Pericostal suture technique, Intracostal suture technique
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 99 Years
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 24, 2020 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Clinical Trial Comparing Standard Wound Closure Techniques Versus TissuGlu® Surgical Adhesive

NCT01791504
View directory record Official record
Conditions
Disorder of Skin and/or Subcutaneous Tissue of Trunk
Interventions
TissuGlu Surgical Adhesive
Device
Lead sponsor
Cohera Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Huntersville, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Not applicable Interventional

Pelvic Floor Support After Laparoscopic Hysterectomy for Benign Conditions: A Randomized Controlled Trial Comparing Vaginal Cuff Closure Techniques

NCT03753516
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Laparoscopic - Vaginal Cuff Closure, Vaginal- Vaginal Cuff Closure
Procedure
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 4, 2026, 7:52 PM EDT
Recruiting Not applicable Interventional

Tract Closure in PCNL

NCT07668817
View directory record Official record
Conditions
Nephrolithiasis
Interventions
Floseal, Surgicel, Surgiflo, Balloon Tamponade
Device · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Sutures vs. Staples Skin Closure After C-section in Obese Patients

NCT01820221
View directory record Official record
Conditions
Obesity, Pregnancy
Interventions
Suture vs. staples closure method after c-section in obese women.
Procedure
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional

Suture Closure Trial

NCT05261425
View directory record Official record
Conditions
Surgical Wound, Upper Extremity Injury
Interventions
Monocryl buried, Nylon (FDA Approved) not buried
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years to 99 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 4, 2026, 7:52 PM EDT
Not listed Not applicable Interventional

Optimal Method of Fascial Closure in High Risk Patients Undergoing Laparotomy

NCT02145052
View directory record Official record
Conditions
Fascial Closure
Interventions
Continuous suture, Interrupted suture
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
388 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 28, 2016 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Not applicable Interventional

A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids

NCT00519493
View directory record Official record
Conditions
Keloid
Interventions
Suture, Clozex
Procedure · Device
Lead sponsor
University of Miami
Other
Eligibility
12 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional Results available

Orthopaedic Surgical Wound Closure Comparison Study

NCT05251064
View directory record Official record
Conditions
Incision, Surgical
Interventions
Suture, Clozex, Zipline
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Sep 4, 2026, 7:52 PM EDT
Recruiting Phase 4 Interventional

Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

NCT07225101
View directory record Official record
Conditions
Wound Closure, Brain Tumor Adult, Spine, Neurovascular, Hemorrhagic Stroke, Intracerebral, Traumatic Brain Injury
Interventions
STRATAFIX PDS and Monocryl suture
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated No phase listed Observational

Evaluating Outcomes in the Placement of Boomerang Percutaneous Device

NCT00732628
View directory record Official record
Conditions
Medical Device, Angiography
Interventions
Boomerang closure device
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 23, 2009 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Not applicable Interventional

A Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Techniques Plus Sylys® Surgical Sealant

NCT02841891
View directory record Official record
Conditions
Colorectal and Ileorectal Anastomosis, Colocolic and Ileocolic Anastomosis, Coloanal and Ileoanal Anastomosis
Interventions
Sylys® Surgical Sealant, Stapled Anastomosis Colectomy Procedure
Device · Procedure
Lead sponsor
Cohera Medical, Inc.
Industry
Eligibility
22 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
16
States / cities
Birmingham, Alabama • Mobile, Alabama • Orange, California + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional

Wound Closure Techniques in Primary Spine Surgery

NCT04396613
View directory record Official record
Conditions
Spinal Injuries
Interventions
Closure technique
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Postoperative Pain and Skin Closure Methods After Cesarean Section

NCT02028000
View directory record Official record
Conditions
Pregnancy
Interventions
Insorb staples skin closure, Monocryl skin closure, Vicryl skin closure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2017 · Synced Sep 4, 2026, 7:52 PM EDT
Withdrawn Phase 2 Interventional

A Study to Evaluate Adverse Events and Effectiveness of OnabotulinumtoxinA in Participants Undergoing Open Abdominal Ventral Hernia Repair for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique

NCT05606757
View directory record Official record
Conditions
Ventral Hernia, Abdominal Hernia
Interventions
BOTOX Dose A, Placebo for BOTOX, BOTOX Dose B, BOTOX Dose C
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Mineola, New York • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 4, 2026, 7:52 PM EDT
Terminated Phase 3 Interventional

PleuraSeal Pivotal Study (US)

NCT00748124
View directory record Official record
Conditions
Open Thoracotomy
Interventions
PleuraSeal Sealant System, Standard Tissue Closure Techniques
Device · Procedure
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2014 · Synced Sep 4, 2026, 7:52 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas

NCT00889213
View directory record Official record
Conditions
Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
Interventions
Falciform patch and fibrin glue application, standard pancreatic closure
Procedure
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
2
States / cities
Cleveland, Ohio • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2014 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ultrasound Study of the Uterine Healing Process After Cesarean Delivery

NCT00224250
View directory record Official record
Conditions
Myometrial Remodeling
Interventions
One- versus two-layer hysterotomy closure
Procedure
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 4, 2026, 7:52 PM EDT
Completed Not applicable Interventional

Evaluation of Purse-String Closure Vs Second Intention

NCT02062866
View directory record Official record
Conditions
Wound Closure Techniques
Interventions
Purse-String, Second Intent
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Sep 4, 2026, 7:52 PM EDT