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Showing 1–24 of 408 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cocaine Related Disorders Clear all
Completed Phase 2 Interventional

Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5

NCT00015223
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1999
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Recruiting Phase 2 Interventional

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder

NCT07227948
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Semaglutide, Placebo, cognitive behavioral therapy (CBT).
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional

Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7

NCT00015106
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Lamotrigine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 59 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1999
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional

A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence

NCT01651364
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
Interventions
Placebo, Cabergoline
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2012 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional

Cocaine Effects in Humans: Physiology and Behavior - 1

NCT00000200
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Methadone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1998
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Recruiting No phase listed Observational

Substance Abuse Pre-Treatment Screening Study

NCT00439049
View directory record Official record
Conditions
Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence, Substance Abuse
Interventions
modafinil, d-amphetamine, L-Dopa, Naltrexone
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
7,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 19, 2023 · Synced Jun 26, 2026, 2:57 PM EDT
Not listed Phase 1 Interventional

Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13

NCT00000348
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Dihydrexidine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 3 Interventional

Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10

NCT00000293
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Nefazodone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Early Phase 1 Interventional

The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues

NCT02939352
View directory record Official record
Conditions
Alcoholism, Cocaine Addiction, Drug Addiction
Interventions
Real continuous Theta Burst Stimulation, Sham continuous Theta Burst Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
25 Years to 55 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2018 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1Phase 2 Interventional Results available

PPARγ Agonist Treatment for Cocaine Dependence

NCT02774343
View directory record Official record
Conditions
Cocaine Use Disorder, Alcohol Use Disorder
Interventions
Pioglitazone, Placebo, Therapy, Contingency Management
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Improving Learning-based Treatment of Cocaine Dependence With Medication

NCT01526538
View directory record Official record
Conditions
COCAINE-RELATED DISORDERS
Interventions
d-cycloserine, sugar pill
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional

Prepulse Inhibition of Startle in Cocaine Dependence - 7

NCT00015249
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Amantadine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1998
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Recruiting Not applicable Interventional

Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder

NCT05986578
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
TMS to dmPFC, TMS to dlPFC, Sham iTBS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional Results available

Modafinil, Sleep Architecture and Cocaine Relapse

NCT01137396
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
25 Years to 50 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 26, 2016 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional Results available

Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study

NCT02563769
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
Interventions
Clavulanic acid, Intravenous cocaine, Placebo
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Not applicable Interventional Results available

Cocaine Withdrawal and Pharmacotherapy Response

NCT00566969
View directory record Official record
Conditions
Cocaine Dependence, Opiate Dependence
Interventions
sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional

Cocaethylene as a Treatment for Cocaine Dependence - 1

NCT00124696
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Cocaethylene
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional

Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid

NCT03986762
View directory record Official record
Conditions
Cocaine Dependence, in Remission, Cocaine Abuse, in Remission, Cocaine-Related Disorders
Interventions
Clavulanic Acid
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 25, 2020 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional Results available

Carvedilol for Psychostimulant Dependence

NCT01171183
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Withdrawal
Interventions
controlled release carvedilol, Placebo
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Not applicable Interventional

Behavioral Incentives to Increase Exercise in Cocaine Dependent Women

NCT01283191
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Behavioral Incentives, Education Control
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 17, 2014 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Not applicable Interventional

sTMS for Substance Use-disordered Veterans

NCT04336293
View directory record Official record
Conditions
Cocaine Addiction, Opioid Addiction, Alcohol Addiction
Interventions
sTMS, sham sTMS
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 1 Interventional

Methylphenidate Treatment for Cocaine Abuse and ADHD - 1

NCT00136734
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Interventions
Methylphenidate, placebo
Drug · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Jun 26, 2026, 2:57 PM EDT
Completed Phase 2 Interventional Results available

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

NCT00218387
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jun 26, 2026, 2:57 PM EDT