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ClinicalTrials.gov public records Last synced Oct 18, 2026, 10:51 AM EDT

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Showing 385–408 of 408 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine Related Disorders Clear all
Completed Phase 2 Interventional

Mazindol for Cocaine Abuse - 2

NCT00000277
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Mazindol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 1999
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Pharmacological Modulation of Cocaine Effects - 1

NCT00000201
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Selegiline
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2001
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2Phase 3 Interventional

Recovery Housing For Drug Dependent Pregnant Women

NCT00497302
View directory record Official record
Conditions
Drug Addiction
Interventions
RBT, usual care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues

NCT00585520
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Progesterone, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 12, 2014 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3

NCT00000286
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Nefazodone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients

NCT00577005
View directory record Official record
Conditions
Cocaine Dependence, Opioid Dependency
Interventions
levetiracetam, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Disulfiram for Cocaine Abuse

NCT00395850
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Disulfiram
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 13, 2013 · Synced Oct 18, 2026, 10:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Impulsivity, Neural Deficits and Cocaine Addiction

NCT00744601
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 55 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Oct 18, 2026, 10:51 AM EDT
Not listed Phase 1 Interventional

Infusion Laboratory: Protocol 5 (Flupenthixol) - 14

NCT00000349
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Flupenthixol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Risperidone for the Treatment of Cocaine Dependence - 7

NCT00000342
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Risperidone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1997
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 16, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

New Approaches to Cocaine Abuse Medications (A) - 6

NCT00000271
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Desipramine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2002
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Results available

Clinical Trial of Topiramate for Cocaine Addiction

NCT00685178
View directory record Official record
Conditions
Cocaine Dependence
Interventions
topiramate, Contingency Reinforcement, placebo + NonCR
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Effects of Phenytoin on Cocaine Use in Humans - 2

NCT00000285
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Phenytoin
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

IV Cocaine Abuse: A Laboratory Model - 2

NCT00000213
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Fluoxetine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 1991
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2015 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Infusion Laboratory: Protocol 1 - Selegeline - 2

NCT00000337
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Selegiline
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
31 Years to 47 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1994
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional

Efficacy and Safety of TV-1380 as Treatment for Facilitation of Abstinence in Cocaine-Dependent Subjects

NCT01887366
View directory record Official record
Conditions
Cocaine Addiction
Interventions
TV-1380 150 mg, TV-1380 300 mg, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
14
States / cities
Los Angeles, California • Oceanside, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2015 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Cocaine-Methylphendidate Interaction Study - 4

NCT00015067
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse

NCT02080819
View directory record Official record
Conditions
Cocaine Dependence
Interventions
levodopa/carbidopa 400/100 BID
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Not applicable Interventional Results available

Galantamine Effects on Cognitive Function in Abstinent Cocaine Users

NCT00606801
View directory record Official record
Conditions
Cocaine Abuse
Interventions
Galantamine, placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 3 Interventional

Combining Behavioral Treatment With Agonist Maintenance - 1

NCT00000311
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
Interventions
Buprenorphine, methadone
Drug
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 1999
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Rivastigmine and Huperzine A as Treatments for Cocaine Dependence

NCT01030692
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
Interventions
Placebo, Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg, Huperzine A 0.8 mg
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2015 · Synced Oct 18, 2026, 10:51 AM EDT
Completed Phase 1 Interventional

Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)

NCT01437293
View directory record Official record
Conditions
Cocaine Abuse
Interventions
L-dopa / carbidopa / entacapone (LCE)
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 18, 2026, 10:51 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

First in Humans Study of JDTic

NCT01431586
View directory record Official record
Conditions
Cocaine Dependence
Interventions
JDtic
Drug
Lead sponsor
RTI International
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated May 10, 2012 · Synced Oct 18, 2026, 10:51 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use

NCT02927236
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence
Interventions
Transcranial magnetic stimulation (TMS)
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
22 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 18, 2026, 10:51 AM EDT