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ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:04 AM EDT

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Showing 145–168 of 408 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine Related Disorders Clear all
Completed Not applicable Interventional Results available

The Therapeutic Workplace Initiation Study

NCT00249470
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
Interventions
Abstinence & Work, Work Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 27, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1

NCT00158288
View directory record Official record
Conditions
Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence, LAAM, Opioid Dependence, Substance-Related Disorders, Alcohol & Drug Use
Interventions
LAAM
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2001
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Results available

VIVITROL as a Treatment for Cocaine and Alcohol Dependence

NCT00777062
View directory record Official record
Conditions
Cocaine Dependence, Alcohol Dependence
Interventions
VIVITROL (Naltrexone extended-release injectable suspension), Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2018 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional

Nefazodone in the Treatment of Cocaine Dependence and Depression - 4

NCT00015210
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Nefazodone, Psychosocial Treatment
Drug · Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
21 Years to 55 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Results available

Treatment of Cocaine Dependence With Lisdexamfetamine

NCT00958282
View directory record Official record
Conditions
Cocaine Dependence
Interventions
lisdexamfetamine/Behavior Therapy, placebo
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 17, 2015 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)

NCT02406066
View directory record Official record
Conditions
Cocaine Use Disorder, Tobacco Use Disorder
Interventions
metyrapone & oxazepam, Placebo
Drug
Lead sponsor
Embera NeuroTherapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
2
States / cities
Long Beach, California • Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 22, 2016 · Synced Oct 17, 2026, 2:04 AM EDT
Terminated Phase 1 Interventional

Amphetamine Cocaine Interaction Study - 2

NCT00000305
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Dextroamphetamine
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 45 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2012 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1 Interventional

Open Label Pharmaco- Magnetic Resonance Spectrography (MRS) Study of Clavulanic Acid

NCT03986762
View directory record Official record
Conditions
Cocaine Dependence, in Remission, Cocaine Abuse, in Remission, Cocaine-Related Disorders
Interventions
Clavulanic Acid
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2020 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Valproate Efficacy in Cocaine-Bipolar Comorbidity

NCT00240110
View directory record Official record
Conditions
Bipolar Disorder, Cocaine Dependence
Interventions
Valproate, Placebo, Lithium Carbonate
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2014
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2016 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Results available

Chantix for Treating Cocaine Dependence

NCT00567008
View directory record Official record
Conditions
Cocaine Dependence
Interventions
varenicline, placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 7, 2013 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 4 Interventional

Attention Training for Opioid-maintained Cocaine Users

NCT01870882
View directory record Official record
Conditions
Addiction, Cocaine, Methadone, Opiates
Interventions
Attentional retraining, Control condition
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 2, 2020 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1 Interventional

Long Term Maintenance of Drug Abstinence

NCT00842517
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Abuse
Interventions
Contingency Management
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Results available

Citalopram for Cocaine Dependence

NCT01535573
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Citalopram, Placebo
Drug
Lead sponsor
Joy Schmitz
Other
Eligibility
18 Years to 60 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Improving Learning-based Treatment of Cocaine Dependence With Medication

NCT01526538
View directory record Official record
Conditions
COCAINE-RELATED DISORDERS
Interventions
d-cycloserine, sugar pill
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

NCT05857852
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Interventions
Low-Intensity Focused Ultrasound, Sham LIFU device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 3 Interventional

Buprenorphine Maintenance for Cocaine Abusing Opioid Addicts - 1

NCT00000216
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
Interventions
Buprenorphine
Drug
Lead sponsor
Yale University
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2005
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional

High Dose Nimodipine Treatment Adjunct - 1

NCT00000332
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Nimodipine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
22 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2000
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 24, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1 Interventional Results available

Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study

NCT02563769
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
Interventions
Clavulanic acid, Intravenous cocaine, Placebo
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2023 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Doxazosin for Psychostimulant Dependence

NCT01371851
View directory record Official record
Conditions
Methamphetamine or Cocaine Dependence
Interventions
Doxazosin extended release
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2015 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional

Selegiline in Treatment of Cocaine Dependence - 2

NCT00000188
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Selegiline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 1995
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 17, 2026, 2:04 AM EDT
Terminated Phase 1 Interventional

Predictive Values of Serotonergic Alterations for Outcome - 2

NCT00000313
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Fenfluramine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
25 Years to 50 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional

Effects of Labetalol on Human Cocaine Use - 8

NCT00000291
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Labetalol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional

Gepirone vs Placebo in Treatment of Cocaine Dependence - 3

NCT00000189
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Gepirone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
Male only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 1991
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 17, 2026, 2:04 AM EDT
Completed Phase 2 Interventional Results available

Modafinil, Sleep Architecture and Cocaine Relapse

NCT01137396
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
25 Years to 50 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 27, 2016 · Synced Oct 17, 2026, 2:04 AM EDT