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ClinicalTrials.gov public records Last synced Oct 17, 2026, 3:33 AM EDT

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Showing 193–216 of 408 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine Related Disorders Clear all
Not listed Phase 2 Interventional

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

NCT06434818
View directory record Official record
Conditions
Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder, Methamphetamine-dependence
Interventions
EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks, CBOT Sham
Combination Product
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional Results available

Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence

NCT00385268
View directory record Official record
Conditions
Cocaine Dependence
Interventions
acamprosate, placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional

Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1

NCT00000245
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Desipramine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 2001
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 4 Interventional

Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11

NCT00015301
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Not applicable Interventional

Metabolic Effects of Cocaine

NCT00451230
View directory record Official record
Conditions
Cocaine Dependence
Interventions
cocaine, hydrocortisone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 49 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Withdrawn Phase 2 Interventional

D-Serine for Cocaine Dependence Pilot

NCT01715051
View directory record Official record
Conditions
Cocaine Dependence
Interventions
D-serine, Cognitive Behavioral Therapy, Placebo
Drug · Behavioral
Lead sponsor
Theresa Winhusen
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Oct 17, 2026, 3:33 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Brain Imaging Studies of the Effects of Cocaine Abstinence

NCT00581282
View directory record Official record
Conditions
Substance Abuse Disorder
Interventions
PET scan, fMRI
Radiation · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Multiple Ascending Dose Study of TMP-301 in Healthy Subjects

NCT06025396
View directory record Official record
Conditions
Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
Interventions
Cohort 1 - TMP-301, Placebo, Cohort 2 - TMP-301, Cohort 3 - TMP-301, Cohort 4 - TMP-301
Drug
Lead sponsor
Tempero Bio, Inc.
Industry
Eligibility
18 Years to 59 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 3 Interventional Results available

Smoking-Cessation and Stimulant Treatment (S-CAST)

NCT01077024
View directory record Official record
Conditions
Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
Interventions
Smoking-cessation treatment
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
538 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
Tucson, Arizona • Rancho Cucamonga, California • Tarzana, California + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional

Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder

NCT05886582
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Rotigotine Transdermal System [Neupro], Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
25 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 1 Interventional

Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin

NCT01723527
View directory record Official record
Conditions
Cocaine-Related Disorders, HIV, Heroin Dependence
Interventions
Methadone, Buprenorphine, Employment-based drug abstinence reinforcement
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 11, 2014 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional Results available

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

NCT01929343
View directory record Official record
Conditions
Cocaine Addiction
Interventions
lidocaine following cue-induced craving, lidocaine following neutral stimulus, saline
Drug
Lead sponsor
Bryon Adinoff
Other
Eligibility
25 Years to 60 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 31, 2020 · Synced Oct 17, 2026, 3:33 AM EDT
Withdrawn Phase 2 Interventional

Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics

NCT01406522
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Oral tacrine, Oral placebo
Drug
Lead sponsor
Midwest Biomedical Research
Other
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 18, 2013 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Vigabatrin for the Treatment of Cocaine Dependency

NCT01281202
View directory record Official record
Conditions
Cocaine Addiction, Cocaine Dependence
Interventions
Vigabatrin, Matching Placebo
Drug
Lead sponsor
Catalyst Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
13
States / cities
Los Angeles, California • Torrance, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated May 18, 2016 · Synced Oct 17, 2026, 3:33 AM EDT
Completed No phase listed Observational

Non-Treatment Study of Factors Affecting Cocaine Drug Choice

NCT00946660
View directory record Official record
Conditions
Cocaine Abuse or Dependence, Cocaine Related Disorders
Interventions
Not listed
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 55 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2012 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Aripiprazole on Cocaine Craving and Self-Administration

NCT00373880
View directory record Official record
Conditions
Cocaine Abuse
Interventions
Aripiprazole + Cocaine, Placebo + Cocaine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional

Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence

NCT00218075
View directory record Official record
Conditions
Cocaine Abuse, Cocaine-Related Disorders
Interventions
Levodopa, Carbidopa, Clinical Management, Relapse Prevention Therapy, Contingency Management
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 1 Interventional

Prepulse Inhibition of Startle in Cocaine Dependence - 7

NCT00015249
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Amantadine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1998
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Oxytocin and Cognitive Behavioral Therapy in Drug Dependence

NCT00975416
View directory record Official record
Conditions
Drug Dependence
Interventions
Cognitive Behavioral Therapy, Intranasal Oxytocin, Placebo
Behavioral · Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2015 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional

Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7

NCT00015106
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Lamotrigine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 59 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1999
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users

NCT01614106
View directory record Official record
Conditions
HIV, AIDS, Substance Abuse
Interventions
Retention Clinic
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
2
States / cities
Miami, Florida • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional Results available

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

NCT00218387
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 10, 2019 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Phase 2 Interventional

Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence - 4

NCT00000301
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Amantadine
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1996
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 17, 2026, 3:33 AM EDT
Completed Early Phase 1 Interventional

Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

NCT02994875
View directory record Official record
Conditions
Cocaine Dependence
Interventions
N-acetylcysteine, Placebo
Dietary Supplement · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 17, 2026, 3:33 AM EDT