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ClinicalTrials.gov public records Last synced Oct 11, 2026, 9:55 AM EDT

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Showing 217–240 of 408 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Cocaine-Related Disorder Clear all

Conditions: Cocaine-Related Disorders, Substance-Related Disorders
Interventions: Dextroamphetamine, D-Amphetamine, Placebo; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 45 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2001
U.S. locations: 1
States / cities: Houston, Texas

Conditions: COCAINE-RELATED DISORDERS
Interventions: d-cycloserine, sugar pill; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opiate Dependence, Cocaine Dependence
Interventions: 11UCB-J PET Scan; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine Dependence, Cannabis Dependence, Schizophrenia
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 64 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Cocaine Dependence
Interventions: Modafinil, Matching Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine Abuse
Interventions: Aripiprazole + Cocaine, Placebo + Cocaine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Cocaine Related Disorders
Interventions: Guanfacine, Modafinil, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 109 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine-Related Disorders
Interventions: Baclofen; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1997
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cocaine Dependence
Interventions: Acthrel; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine-Related Disorders, Substance-Related Disorders
Interventions: Risperidone, Placebo, Relapse prevention counseling; Drug · Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 1999
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions: DynamiCare app (app-based contingency management), Sham control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Milwaukee, Wisconsin

Conditions: Cocaine Dependence
Interventions: D-serine, Cognitive Behavioral Therapy, Placebo; Drug · Behavioral
Lead sponsor: Theresa Winhusen; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Interventions: Atomoxetine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Cocaine Dependence
Interventions: Mirtazapine 15 MG Oral Tablet; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Cocaine Dependence
Interventions: Voucher Reinforcement, Extra Counseling Services, Voucher Reinforcement + Extra Counseling Services; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Timeline: Ends 2007
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Dependence
Interventions: Modafinil, Cognitive Behavioral Therapy; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 25 Years to 50 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine, Substance Abuse, Infant, Newborn, Pregnancy, Pregnant Women, Prenatal Care
Interventions: Not listed
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Not listed
Enrollment: 11,811 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1993 – 2011
U.S. locations: 5
States / cities: Miami, Florida • Detroit, Michigan • Durham, North Carolina + 2 more

Conditions: Cocaine Dependence
Interventions: Recovery Support Counseling; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 75 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine-Related Disorders
Interventions: M-CPP; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 25 Years to 50 Years · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1994 – 1999
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Alcohol-Related Disorders, Cocaine-Related Disorders
Interventions: Disulfiram; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1994 – 1999
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine Dependence
Interventions: TA-CD Vaccination, Placebo Injection; Drug · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 6
States / cities: Baltimore, Maryland • New York, New York • Cincinnati, Ohio + 2 more

Conditions: Cocaine Dependence
Interventions: Not listed
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine-Related Disorders, Substance-Related Disorders
Interventions: Reserpine; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 99 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2003
U.S. locations: 3
States / cities: Boston, Massachusetts • Cincinnati, Ohio • Dayton, Ohio

Conditions: Cocaine-Related Disorders
Interventions: Gonadorelin; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2001
U.S. locations: 1
States / cities: Belmont, Massachusetts

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Dextroamphetamine as an Adjunct in Cocaine Treatment - 1

Improving Learning-based Treatment of Cocaine Dependence With Medication

Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

Effects of Aripiprazole on Cocaine Craving and Self-Administration

Stress and Medication Effects on Cocaine Cue Reactivity

Rapid Evaluation of Baclofen for Treatment of Cocaine Abuse/Dependence - 6

Gender and Neural Substrates of Stress and Craving

Early Phase II Trials for Cocaine Medication Development - 1

Contingency Management for Drug Use: Does Age Matter?

D-Serine for Cocaine Dependence Pilot

Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD)

5HT2CR Balance in Brain Connectivity in Cocaine Dependence

Effectiveness and Costs of Enhanced Cocaine Treatments

Modafinil, Sleep Architecture and Cocaine Relapse

The Maternal Lifestyle Study (MLS)

Effectiveness of Extended Treatment for Drug Dependence (ETDD) in the City Study

M-CPP and Fenfluramine in Cocaine Addicts - 3

Disulfiram for Cocaine-Alcohol Abuse - 3

Multisite Controlled Trial of Cocaine Vaccine

Gender Differences in Response to Cues in Cocaine Dependence

Reserpine for the Treatment of Cocaine Dependence - 1

Psychostimulant Abuse - Novel Treatment Approaches - 1