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ClinicalTrials.gov public records Last synced Oct 6, 2026, 5:36 PM EDT

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Showing 97–120 of 408 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine-Related Disorder Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Impulsivity and Stimulant Administration

NCT01978431
View directory record Official record
Conditions
Cocaine Dependence, Impulsivity
Interventions
cocaine hydrochloride, methylphenidate
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1Phase 2 Interventional

Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers

NCT00656357
View directory record Official record
Conditions
Cocaine Dependence
Interventions
SYN117 Placebo, SYN117 80 mg, SYN117 160 mg, Cocaine 10mg, Cocaine 20mg, Cocaine 40mg, Saline
Drug
Lead sponsor
Biotie Therapies Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2018 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1 Interventional

Complementary Combination Therapy for Cocaine Dependence

NCT02538744
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Doxazosin, Modafinil, cocaine, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse

NCT01953432
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Doxazosin, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 64 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Oct 6, 2026, 5:36 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

NCT01535937
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 60 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1 Interventional

ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine

NCT01366001
View directory record Official record
Conditions
Cocaine Abuse
Interventions
ALKS 33-BUP, ALKS 33, Placebo
Drug
Lead sponsor
Alkermes, Inc.
Industry
Eligibility
21 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2012 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Not applicable Interventional Results available

Employment-based Reinforcement of Naltrexone Ingestion and Abstinence

NCT00149669
View directory record Official record
Conditions
Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
Interventions
employment-based reinforcement
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional

10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence

NCT03238859
View directory record Official record
Conditions
Cocaine Dependence, Alcohol Dependence
Interventions
Real cTBS, Sham cTBS
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Results available

A Multi-Center Trial of Nepicastat for Cocaine Dependence

NCT01704196
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Nepicastat, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
10
States / cities
Los Angeles, California • San Diego, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Oct 6, 2026, 5:36 PM EDT
Not listed Not applicable Interventional

Pharmacotherapy for HIV+ Stimulant Dependent Individuals

NCT00599573
View directory record Official record
Conditions
HIV Infections, Cocaine Dependence
Interventions
ondansetron
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 14, 2010 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 4 Interventional Results available

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

NCT03526354
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
Interventions
Brexpiprazole, Treatment as Usual
Drug · Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
4
States / cities
Augusta, Georgia • Boston, Massachusetts • Worcester, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 23, 2025 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1Phase 2 Interventional Results available

PPARγ Agonist Treatment for Cocaine Dependence

NCT02774343
View directory record Official record
Conditions
Cocaine Use Disorder, Alcohol Use Disorder
Interventions
Pioglitazone, Placebo, Therapy, Contingency Management
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 26, 2018 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone

NCT00218608
View directory record Official record
Conditions
Cocaine-Related Disorders, Opioid-Related Disorders
Interventions
Disulfiram
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jan 31, 2012 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Results available

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

NCT01822587
View directory record Official record
Conditions
Cocaine Addiction
Interventions
Propranolol, 40 mg, Propranolol, 80 mg, Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 26, 2019 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Results available

Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence

NCT00142818
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
Interventions
Naltrexone, Modafinil, Placebo
Drug
Lead sponsor
Kyle Kampman
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Behavioral Incentives to Increase Exercise in Cocaine Dependent Women

NCT01283191
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Behavioral Incentives, Education Control
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Not applicable Interventional

A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence

NCT00227123
View directory record Official record
Conditions
Bipolar Disorder, Cocaine Dependence, Methamphetamine Dependence
Interventions
quetiapine, risperidone
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
20 Years to 50 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
2
States / cities
Dallas, Texas • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 4, 2008 · Synced Oct 6, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder

NCT05986578
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
TMS to dmPFC, TMS to dlPFC, Sham iTBS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional

Topiramate to Reduce Cocaine Dependence

NCT00223626
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Topiramate
Drug
Lead sponsor
Bankole Johnson
Other
Eligibility
18 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Charlottesville, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Doxazosin for Psychostimulant Dependence

NCT01371851
View directory record Official record
Conditions
Methamphetamine or Cocaine Dependence
Interventions
Doxazosin extended release
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2015 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Recovery Housing and Drug Abuse Treatment Outcome

NCT03278496
View directory record Official record
Conditions
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Interventions
Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 1 Interventional Results available

Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study

NCT02563769
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
Interventions
Clavulanic acid, Intravenous cocaine, Placebo
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2023 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional Results available

Stimulant Oxytocin Study

NCT03016598
View directory record Official record
Conditions
Stimulant Use & Co-occuring Opioid Use Disorders
Interventions
Intranasal oxytocin, Intranasal placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Sacramento, California • San Francisco, California • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Oct 6, 2026, 5:36 PM EDT
Completed Phase 2 Interventional

Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4

NCT00000307
View directory record Official record
Conditions
Alcohol-Related Disorders, Cocaine-Related Disorders
Interventions
Naltrexone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 6, 2026, 5:36 PM EDT