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Showing 1–24 of 408 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cocaine-related Disorders Clear all
Completed Not applicable Interventional

Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment

NCT01376570
View directory record Official record
Conditions
HIV, Opiate Dependence
Interventions
Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 22, 2026, 7:14 PM EDT
Terminated Phase 1 Interventional

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

NCT00688805
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Propranolol, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional Results available

Therapeutic Substance Abuse Treatment in Pregnancy - 1

NCT00227903
View directory record Official record
Conditions
Alcohol Abuse, Cocaine Abuse, Marijuana Abuse
Interventions
MI-CBT, Brief Advice
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Bridgeport, Connecticut • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence

NCT00385801
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Risperidone, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Modafinil for the Treatment of Cocaine Dependence - 1

NCT00100100
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Modafinil
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
6
States / cities
Boston, Massachusetts • New York, New York • Cincinnati, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Clinical Trial of Abstinence-Linked Money Management

NCT00536900
View directory record Official record
Conditions
Substance Abuse
Interventions
Advisor-Teller Money Manager, FIT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 29, 2020 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients

NCT00780702
View directory record Official record
Conditions
Cocaine Dependence, Cocaine-Related Disorders, Opioid-Related Disorders
Interventions
Airipiprazole, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence

NCT00218075
View directory record Official record
Conditions
Cocaine Abuse, Cocaine-Related Disorders
Interventions
Levodopa, Carbidopa, Clinical Management, Relapse Prevention Therapy, Contingency Management
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrated BA and HIV RR Counseling for MSM With Stimulant Abuse

NCT03175159
View directory record Official record
Conditions
Stimulant Abuse, HIV Prevention, Substance Abuse
Interventions
IMPACT, Standard of Care
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
205 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
2
States / cities
Miami, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 24, 2024 · Synced Sep 22, 2026, 7:14 PM EDT
Terminated Phase 2 Interventional

Serotonin/Dopamine Antagonism of Cocaine Effect: 1 - 1

NCT00000309
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Risperidone
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 2000
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 23, 2015 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional Results available

A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction

NCT00567814
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Addiction
Interventions
Metyrapone, Oxazepam, Placebo
Drug
Lead sponsor
Embera NeuroTherapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin

NCT02393599
View directory record Official record
Conditions
Cocaine Abuse
Interventions
Lorcaserin, Placebo, Cocaine Infusion
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional Results available

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

NCT00218387
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 22, 2026, 7:14 PM EDT
Not listed Phase 1 Interventional

Drug Interaction Study With NS2359 and Cocaine in Cocaine Experienced Volunteers - 1

NCT00032916
View directory record Official record
Conditions
Cocaine-Related Disorders, Drug Administration Schedule, Infusions, Intravenous
Interventions
NS2359
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Extended Treatments for Drug Dependence

NCT00685659
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Intensive Outpatient Treatment, Adaptive telephone-based counseling, Adaptive telephone-based counseling plus incentives
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 75 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336 in Healthy, Male Subjects

NCT00808119
View directory record Official record
Conditions
Cocaine Dependence
Interventions
RTI-336 (CTDP 31862)
Drug
Lead sponsor
RTI International
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Miramar, Florida
Source: ClinicalTrials.gov public record
Updated Jul 20, 2009 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Effects of Carvedilol on Cocaine Use in Humans - 11

NCT00000294
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Carvedilol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Multiple Ascending Dose Study of TMP-301 in Healthy Subjects

NCT06025396
View directory record Official record
Conditions
Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
Interventions
Cohort 1 - TMP-301, Placebo, Cohort 2 - TMP-301, Cohort 3 - TMP-301, Cohort 4 - TMP-301
Drug
Lead sponsor
Tempero Bio, Inc.
Industry
Eligibility
18 Years to 59 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Risperidone for the Treatment of Cocaine Dependence - 7

NCT00000342
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Risperidone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1997
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 1 Interventional Results available

Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid

NCT04411914
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Clavulanic Acid, Placebo
Drug · Other
Lead sponsor
Temple University
Other
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional Results available

Efficacy of Varenicline in Methadone-Stabilized Cocaine Users

NCT00567320
View directory record Official record
Conditions
Cocaine Dependence, Nicotine Dependence
Interventions
Varenicline, Sugar pill or Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PET Imaging in Cocaine Self Administration

NCT02181491
View directory record Official record
Conditions
Cocaine Dependence
Interventions
[11C]-P943
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Not applicable Interventional

The Effect of Self-Forgiveness on Self-Stigma in Addiction.

NCT03971097
View directory record Official record
Conditions
Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder, Alcohol Withdrawal, Alcohol Abuse, Alcohol Use Disorder, Cocaine Abuse, Cocaine Use Disorder, Cocaine Withdrawal, Benzodiazepine Abuse, Benzodiazepine Dependence, Substance Abuse, Heroin Overdoses, Heroin Withdrawal, Heroin Abuse
Interventions
Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
McKeesport, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 22, 2026, 7:14 PM EDT
Completed Phase 2 Interventional

Naltrexone in Treatment of Cocaine Dependence - 5

NCT00015080
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Naltrexone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 1996
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 22, 2026, 7:14 PM EDT