Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 2, 2026, 10:56 AM EDT

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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Sleep, Mood, Caffeine Withdrawal, Anxiety, Productivity
Interventions
Clevr Sleeptime, Clevr Matcha, Clevr Chai
Other
Lead sponsor
Clevr Blends
Industry
Eligibility
28 Years to 42 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

NCT05119153
Conditions
Hyperglycemia
Interventions
Placebo Comparator, Light Roasted Coffee, Medium Roasted Coffee, Dark Roasted Coffee
Dietary Supplement
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Raleigh, North Carolina
Conditions
GERD
Interventions
Coffee
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Sacramento, California
Conditions
Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes, Diabetic Nephropathies, Diabetes Complications, Diabetes, Autoimmune
Interventions
Starbucks® Cold brew - 325ml bottle
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 21 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Completed Not applicable Interventional Accepts healthy volunteers Results available

How do You Take Your Coffee Before Anesthesia

NCT04786691
Conditions
Anesthesia, Aspiration, Fasting
Interventions
Addition of half and half to coffee, Addition of non-dairy creamer to coffee, Black
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Little Rock, Arkansas
Completed Phase 1 Interventional Accepts healthy volunteers

Phase 1 Dose Escalation of ArtemiCoffee

NCT04805333
Conditions
Ovarian Cancer
Interventions
Artemisia annua 450mg, Artemisia annua 900mg, Artemisia annua 1350mg, Artemisia annua 1800mg, Artemisia annua - recommended phase II dose
Drug
Lead sponsor
Frederick R. Ueland, M.D.
Other
Eligibility
18 Years and older · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Coffeeberry on Mood, Motivation and Cognitive Performance

NCT04974606
Conditions
Fatigue, Mental, Alertness, Mood, Motivation, Cognitive Performance
Interventions
Cherry-flavored still beverage, Placebo cherry-flavored still beverage
Dietary Supplement · Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
17 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Athens, Georgia
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Providing Coffee to Patients Postoperatively to Decrease Length of Stay in the PACU

NCT03712891
Conditions
PACU Length of Stay, Postoperative Nausea, Postoperative Vomiting, Patient Satisfaction
Interventions
Coffee
Dietary Supplement
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Cincinnati, Ohio
Conditions
Type 2 Diabetes
Interventions
Coffee
Other
Lead sponsor
University of Reading
Other
Eligibility
30 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Berkeley, California
Conditions
Postoperative Ileus
Interventions
caffeinated coffee
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Worcester, Massachusetts
Conditions
Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis, Fibrosis, Liver, Ultrasound Elastography, Proton Magnetic Resonance Spectroscopy
Interventions
Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule., Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

Whole Coffee Fruit Concentrate Pilot Study 1

NCT01965795
Conditions
Brain-derived Neurotrophic Factor (BDNF), Cognitive Function, Affect
Interventions
Whole Coffee Fruit Concentrate (WCFC), Nutrim
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Caffeinated Coffee on Intraocular Pressure

NCT01364207
Conditions
Primary Open Angle Glaucoma
Interventions
Caffeinated Coffee, Decaffeinated Coffee
Other
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
40 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects of Coffee on Glucose Metabolism

NCT00950898
Conditions
Type 2 Diabetes
Interventions
decaff, caffcoff, caffeine, placebo
Other
Lead sponsor
Brooklyn College of the City University of New York
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Brooklyn, New York
Conditions
Healthy
Interventions
Enlicitide
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Tempe, Arizona
Conditions
Atrial Fibrillation, Coffee
Interventions
Consume coffee, Avoid coffee
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Conditions
Cognitive Change
Interventions
Placebo, AmaTea Guayusa Extract, Lion's Mane
Dietary Supplement
Lead sponsor
The Center for Applied Health Sciences, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Canfield, Ohio
Completed Not applicable Interventional Accepts healthy volunteers

Study of Coffee Mannooligosaccharides for Weight Management

NCT00932750
Conditions
Obesity
Interventions
Coffee mannooligosaccharide, Coffee mannooligosaccharides
Dietary Supplement
Lead sponsor
Mondelēz International, Inc.
Industry
Eligibility
20 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
New York, New York
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of High Caffeine Content Coffee on Blood Pressure in Young Adults

NCT04060225
Conditions
High Blood Pressure
Interventions
Coffee
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 30 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Rochester, New York
Conditions
Overweight, Obese, Healthy
Interventions
Coffee, Water
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 45 Years · Female only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Atrial Fibrillation
Interventions
Intravenous caffeine, Masked Placebo
Other
Lead sponsor
Kansas City Heart Rhythm Research Foundation
Other
Eligibility
21 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
9
States / cities
Loma Linda, California • Overland Park, Kansas • Independence, Missouri + 2 more
Conditions
Exercise Performance, Metabolism
Interventions
Beverage Consumption
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 40 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Conditions
Overweight
Interventions
Decaffeinated coffee, Caffeinated coffee, No coffee
Dietary Supplement
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Coffee, Anthocyanins, Exercise Performance
Interventions
Ethiopian Coffee, Supplement, Water (Placebo)
Other · Dietary Supplement
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri