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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:38 AM EDT

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Showing 265–288 of 354 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cognitive Aging Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition

NCT02942888
View directory record Official record
Conditions
Mild Cognitive Impairment, NAD
Interventions
Nicotinamide riboside, Sugar Pill
Dietary Supplement
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2021 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Health Research on Musical Arts

NCT04137913
View directory record Official record
Conditions
Cognitive Impairment, Creativity
Interventions
Musical arts intervention
Behavioral
Lead sponsor
William Marsh Rice University
Other
Eligibility
18 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional

Correlation Between Montreal Cognitive Assessment and Voice Therapy Outcomes in the Aging Treatment- Seeking Population

NCT05187910
View directory record Official record
Conditions
Cognitive Impairment, Voice Disorders, Voicebox Disorders, Cognitive Decline, Swallowing Disorder
Interventions
Speech Therapy, Swallowing Therapy, Upper Airway Therapy
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years to 110 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
4
States / cities
San Francisco, California • Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 21, 2026, 9:38 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1

NCT05811338
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement, Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive Engagement
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
3
States / cities
Tallahassee, Florida • Champaign, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Curcumin and Function in Older Adults

NCT03085680
View directory record Official record
Conditions
Older Adults, Physical Function, Cognitive Function
Interventions
Curcumin, microcrystalline cellulose
Drug
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 99 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 26, 2022 · Synced Oct 21, 2026, 9:38 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Cognitive-Motor Training for AD/ADRD Prevention

NCT07160582
View directory record Official record
Conditions
MCI, Aging
Interventions
Novel CogXergaming Training, Exercise and Education Training Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
55 Years to 90 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online

NCT04582617
View directory record Official record
Conditions
Aging, Cognitive Change
Interventions
Cocoa Extract, Cocoa Extract Placebo, Multivitamin, Multivitamin placebo
Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
65 Years and older
Enrollment
3,959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2023 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly

NCT02874924
View directory record Official record
Conditions
Aging
Interventions
Rapamycin, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
70 Years to 95 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Oct 21, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Wayfinding Intervention and Long-Term Memory

NCT05625425
View directory record Official record
Conditions
Long-Term Memory Decline, Mild Cognitive Impairment
Interventions
LabyrinthVR software, Placebo Games software, Labyrinth Tablet software, Labyrinth VR wireless
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study

NCT05393388
View directory record Official record
Conditions
Cognitive Decline, Alzheimer Disease
Interventions
[18F]AV-1451
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
65 Years and older
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 21, 2026, 9:38 AM EDT
Recruiting No phase listed Observational

Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

NCT04579120
View directory record Official record
Conditions
Alzheimer Disease
Interventions
[11C]-Pittsburgh Compound B ([11C]PiB), F 18 AV-1451 (Flortaucipir)
Drug
Lead sponsor
Tammie L. S. Benzinger, MD, PhD
Other
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Not yet recruiting Not applicable Interventional

Improving Functioning Among Aging Women Veterans

NCT06580470
View directory record Official record
Conditions
Menopause
Interventions
Tailored Cognitive Behavioral Therapy for Menopause
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland • Perry Point, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fasting ENHANCE Pilot Study

NCT05732935
View directory record Official record
Conditions
Overweight and Obesity, Time Restricted Feeding, Alzheimer Disease
Interventions
Time Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation

NCT01958437
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 88 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Decatur, Georgia • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Oct 21, 2026, 9:38 AM EDT
Active, not recruiting No phase listed Observational

The BRAIN Intensive Care Unit (ICU) Study: Bringing to Light the Risk Factors

NCT00392795
View directory record Official record
Conditions
Delirium, Cognition Disorders, Dementia
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
826 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2026
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients

NCT05998031
View directory record Official record
Conditions
Cognitive Impairment, Cognitive Decline
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 95 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Cholinergic Mechanisms of Attention in Aging

NCT04756232
View directory record Official record
Conditions
Subjective Cognitive Decline
Interventions
Mecamylamine Challenge, Placebo Comparator Challenge
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
55 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 21, 2026, 9:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lagged Relationships Between Sleep, Balance, and Cognition in Older Adults

NCT06584136
View directory record Official record
Conditions
Aging
Interventions
Not listed
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 95 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 21, 2026, 9:38 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

NCT06217575
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
Interventions
Alpha neurofeedback training, Visual Attention Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility and Efficacy of A Remote Tai Chi Program in Older Adults

NCT06918678
View directory record Official record
Conditions
Aging
Interventions
Tai Chi intervention, Usual care condiition
Device · Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
60 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 21, 2026, 9:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Piedmont Aging, Cognition & Exercise Study-2

NCT02312843
View directory record Official record
Conditions
Mild Cognitive Impairment, Prediabetes
Interventions
Exercise/Aerobic, Exercise/Stretching
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
50 Years to 89 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 21, 2026, 9:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation of Memory in Aging

NCT05460468
View directory record Official record
Conditions
Mild Cognitive Impairment, MCI
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 21, 2026, 9:38 AM EDT
Not listed Not applicable Interventional

FE-SaLiR: Function Improvement Exercise

NCT04284137
View directory record Official record
Conditions
Disability Physical, Cognitive Impairment
Interventions
Modified FE-SaLiR, Unmodified Chinese Medicine Exercise, Active Control
Behavioral
Lead sponsor
The University of Texas at San Antonio
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Oct 21, 2026, 9:38 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Brain Alerting Mechanism Study

NCT02050386
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Cold pressor stimulation, Sham Stimulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2016 · Synced Oct 21, 2026, 9:38 AM EDT