Independent directory Public ClinicalTrials.gov records United States
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Showing 73–96 of 354 matching trials from the live ClinicalTrials.gov search.
Recruiting No phase listed Observational Accepts healthy volunteers

Tennessee Alzheimer's Project

NCT05372172
Conditions
Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction, Mild Cognitive Impairment, Dementia, Cognition
Interventions
none, observational study
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Conditions
Mild Cognitive Impairment, Accidental Falls, Aging
Interventions
dual-task tai ji quan, standard tai ji quan, stretching
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
65 Years to 95 Years
Enrollment
336 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Springfield, Oregon
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Aging and Estrogen on Cortical Function

NCT01268046
Conditions
Memory Loss, Cognitive Changes, Postmenopausal Symptoms
Interventions
Estradiol oral capsule, transderman estrogen patch, trasdermal placebo patch, placebo oral capsule
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
45 Years to 80 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
Interventions
melatonin, placebo
Dietary Supplement · Other
Lead sponsor
Natalie Denburg
Other
Eligibility
56 Years to 85 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Cognitive Control Abilities Using Mobile Technology in a Senior Living Community

NCT04905849
Conditions
Aging, Cognitive Change
Interventions
Adaptive Cognitive Control Trainer (ACCT), Active Control App
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Conditions
Aging
Interventions
Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions, Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Withdrawn No phase listed Observational Accepts healthy volunteers

The Brain Alerting Mechanism Study

NCT02050386
Conditions
Healthy Volunteers
Interventions
Cold pressor stimulation, Sham Stimulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Completed Not applicable Interventional Accepts healthy volunteers

Speech Perception With High Cognitive Demand

NCT04698356
Conditions
Speech Intelligibility, Aging
Interventions
Auditory-cognitive training paradigm
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 30 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
College Park, Maryland
Completed No phase listed Observational Accepts healthy volunteers

Influence of Fitness on Brain and Cognition

NCT00438347
Conditions
Aging, Cognitive Ability, General
Interventions
Aerobic Exercise, Stretching and toning
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
60 Years to 75 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
2
States / cities
Champaign, Illinois • Urbana, Illinois
Conditions
Cognition Disorders
Interventions
donepezil, Placebo
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
40 Years to 90 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2007
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
Interventions
AROMHA Brain Health Test
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Phase 2 Interventional Accepts healthy volunteers

Cognitive Effects of Aerobic Exercise for MCI Adults

NCT00220467
Conditions
Mild Cognitive Impairment
Interventions
Aerobic exercise
Behavioral
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
55 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
2
States / cities
Seattle, Washington • Tacoma, Washington
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Intermittent Fasting on Brain Health

NCT06019195
Conditions
Intermittent Fasting, Aging
Interventions
Time restricted eating
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
55 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Intervention With Near Infrared Stimulation

NCT03551392
Conditions
Aging
Interventions
Medx Console System, Sham Medx Console System, Vielight 810 intranasal stand alone unit, Sham Vielight 810 intranasal stand alone unit
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
2
States / cities
Tucson, Arizona • Gainesville, Florida
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

NCT03617302
Conditions
Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
Interventions
Experimental: Nitrate-containing, Placebo: Nitrate-depleted
Drug
Lead sponsor
Gary L. Pierce, PhD
Other
Eligibility
50 Years to 79 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Conditions
Aging, HIV
Interventions
Weekly Group Skills, One-time Trifold Brochure titled "HIV: 50 Years or Older"
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated Phase 1 Interventional Accepts healthy volunteers

Oxytocin Aging Study

NCT02069431
Conditions
Inflammation
Interventions
Intranasal Oxytocin spray, Intranasal Placebo spray
Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Gainesville, Florida
Conditions
Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of, Brain Aging, Fatty Acids, Omega-3
Interventions
Alpha-Linolenic Acid (2.6 g/day), Placebo Control Group
Drug · Dietary Supplement
Lead sponsor
Michal Schnaider Beeri, Ph.D.
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Conditions
TBI (Traumatic Brain Injury)
Interventions
EVO multitask video game, EVO words video game
Behavioral
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
60 Years to 85 Years
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
San Francisco, California • Yountville, California
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Health Research on Musical Arts

NCT04137913
Conditions
Cognitive Impairment, Creativity
Interventions
Musical arts intervention
Behavioral
Lead sponsor
William Marsh Rice University
Other
Eligibility
18 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Houston, Texas
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Long-Term Care Planning
Interventions
PlanYourLifespan.org
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
55 Years and older
Enrollment
293 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Aging
Interventions
BAILAMOS™ @home/en casa, ¡En Forma y Fuerte! @home/en casa
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation

NCT01958437
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Transcranial direct current stimulation (tDCS)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 88 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
Decatur, Georgia • Ann Arbor, Michigan
Conditions
Breast Cancer
Interventions
Remotely Delivered Cognitive Behavioral Stress Management Intervention (R-CBSM), Standard of Care Survivorship Care Planning
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older · Female only
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Coral Gables, Florida