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Showing 1–24 of 328 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cognitive Changes Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Compensatory Training to Support Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease

NCT04118985
View directory record Official record
Conditions
Cognitive Symptom, Pre Senile Dementia, Alzheimer Disease
Interventions
Cognitive rehabilitation and health behavior change intervention, Self-implementation
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Jul 22, 2026, 4:22 AM EDT
Recruiting Not applicable Interventional

Amplitude Titration to Improve ECT Clinical Outcomes

NCT05699226
View directory record Official record
Conditions
Depression, ECT, Cognitive Change
Interventions
Soterix Medical Incorporated 4x1 adapter, Traditional ECT device
Device
Lead sponsor
University of New Mexico
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Weight Loss and Cognitive Function in Adults

NCT03685305
View directory record Official record
Conditions
Overweight and Obesity
Interventions
Hypocaloric diet with hunger reduction strategy, Hypocaloric diet without hunger reduction strategy
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
50 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 4:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cannabis Observational Study on Mood, Inflammation, and Cognition

NCT03522103
View directory record Official record
Conditions
Inflammation, Inflammatory Response, Mood, Cognitive Change
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 70 Years
Enrollment
421 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hostile Bias Modification Training (HBMT) Study

NCT04997356
View directory record Official record
Conditions
Anger, Stress, Aggression
Interventions
Hostile Bias Modification Training, Other training
Behavioral
Lead sponsor
Walter Reed Army Institute of Research (WRAIR)
Federal
Eligibility
18 Years to 39 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Results available

DoD PTSD November 13 - Information Processing Modification in the Treatment of PTSD

NCT00604045
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Attention Bias Modification (ABM), Attention Control Condition (ACC)
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 27, 2014 · Synced Jul 22, 2026, 4:22 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Regulation of Craving Training (mROC-T) to Improve Dietary Intake in Rural Adolescent Girls

NCT06723028
View directory record Official record
Conditions
Obesity and Type 2 Diabetes, Diet Modification
Interventions
Regulation of craving training
Behavioral
Lead sponsor
University of Wyoming
Other
Eligibility
15 Years to 18 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 22, 2026, 4:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Goal Setting to Promote Physical Activity Adherence in Midlife Adults

NCT05980052
View directory record Official record
Conditions
Physical Activity, Exercise
Interventions
Physical Activity
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
45 Years to 65 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 4:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mechanisms of Cognitive Change

NCT04103775
View directory record Official record
Conditions
Psychosis
Interventions
Cognitive Remediation, Active Control
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
15 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Neuraceq™ PET for Detection of Brain Changes in Young Athletes Post-concussion

NCT05270083
View directory record Official record
Conditions
Concussion, Brain
Interventions
NeuraCeq PET imaging with intravenous (IV) dose of 300MBq of Neuraceq™ ([F-18]Florbetaben)
Diagnostic Test
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Jul 22, 2026, 4:22 AM EDT
Completed No phase listed Observational

A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome

NCT01580384
View directory record Official record
Conditions
Down Syndrome
Interventions
Not listed
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
12 Years to 30 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
2
States / cities
Tucson, Arizona • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 2, 2015 · Synced Jul 22, 2026, 4:22 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Enhancing Children's Cognitive Function and Achievement Through Carotenoid Consumption

NCT05177679
View directory record Official record
Conditions
Cognitive Change, Achievement, Macular Pigmentation
Interventions
Active supplement, Placebo control
Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
8 Years to 10 Years
Enrollment
288 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Jul 22, 2026, 4:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

NCT05927506
View directory record Official record
Conditions
ADHD, Attention Deficit Hyperactivity Disorder
Interventions
Other
Behavioral
Lead sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Other
Eligibility
12 Years to 17 Years
Enrollment
312 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Multicultural Healthy Diet to Reduce Cognitive Decline

NCT03240406
View directory record Official record
Conditions
Diet Modification, Cognitive Decline, Cognitive Change
Interventions
Multicultural Healthy Diet, Usual Diet plus Self-Care
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
40 Years to 65 Years
Enrollment
393 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects Fortified Nutritional Supplementation on Childhood Cognition

NCT02630667
View directory record Official record
Conditions
Cognitive Ability, General, Dietary Modification
Interventions
SLOW Carbohydrate, MEDIUM Carbohydrate, FAST Carbohydrate
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
9 Years to 10 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Transcranial Near-Infrared Light in Healthy Subjects: a Cerebral Blood Flow Study With Diffuse Correlation Spectroscopy

NCT03740152
View directory record Official record
Conditions
Cognitive Change
Interventions
Transcranial Light Therapy
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Head Impact Exposure in Hawaii High School Football

NCT04020874
View directory record Official record
Conditions
Head Trauma, Cognitive Change, Confidence, Self, Sports Injuries in Children
Interventions
HuTT-2x, HuTT-4x
Behavioral
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
14 Years to 19 Years
Enrollment
496 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online

NCT04582617
View directory record Official record
Conditions
Aging, Cognitive Change
Interventions
Cocoa Extract, Cocoa Extract Placebo, Multivitamin, Multivitamin placebo
Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
65 Years and older
Enrollment
3,959 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2023 · Synced Jul 22, 2026, 4:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Moderators and Mediators of Perceptual Learning

NCT05894967
View directory record Official record
Conditions
Cognitive Change
Interventions
C1 - Standard Perceptual Learning (SPL), C2 - Long Training (LT), C3 - Short Staircases (SS), C4 - Mixed Difficulty (MD), C5 - Noise Training (NT), C6 - Training with Flankers (TWF), C7 - Parafoveal Training (PT), C8 - Stimulus Variety (SV), C8a - Complex Features (CF), C9 - Exogenous Attention Training (ExAT), C10 - Endogenous Attention Training (EnAT), C11 - Multisensory Facilitation (MF), No Contact Control
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 85 Years
Enrollment
1,140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
3
States / cities
Riverside, California • Boston, Massachusetts • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jul 22, 2026, 4:22 AM EDT
Withdrawn Not applicable Interventional

Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury

NCT06380985
View directory record Official record
Conditions
Alcohol Use Disorder, Mild-Moderate Traumatic Brain Injury
Interventions
Personalized VR Alcohol Approach Bias Modification (ApBM) Condition, Sham Condition
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation

NCT06782360
View directory record Official record
Conditions
Healthy, Cognitive Change, Effects of External Neurostimulation on Cognition
Interventions
Active Neurostimulation, Sham Stimulation
Device
Lead sponsor
OpenBCI
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Financial Coaching and Lifestyle Intervention for Diabetes Prevention in Low-income Families

NCT05944549
View directory record Official record
Conditions
Weight Loss
Interventions
Financial coaching using TrustPlus, Brighter Bites, Noom
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs)

NCT01708304
View directory record Official record
Conditions
Alzheimer's Disease, Dementia, Memory Impairment, Cognitive Impairment
Interventions
RDAD
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
510 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Jul 22, 2026, 4:22 AM EDT
Completed Not applicable Interventional

Metabolism of Low Carbohydrate and Ketogenic Diet

NCT05071287
View directory record Official record
Conditions
Diabetic Kidney Disease, Cognitive Function, Weight Loss, Diabetic Control, Type2 Diabetes
Interventions
mHealth + low-fat diet, mHealth + low-carb/ketogenic diet
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Jul 22, 2026, 4:22 AM EDT