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ClinicalTrials.gov public records Last synced Oct 25, 2026, 6:08 AM EDT

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Showing 1–24 of 195 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cognitive Enhancement Clear all
Completed Phase 2 Interventional

Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors

NCT02153957
View directory record Official record
Conditions
Brain Tumor
Interventions
Physical Activity
Behavioral
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
8 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Enhancement and Risk-reduction Through Exercise for Brain-Related Outcomes

NCT05588778
View directory record Official record
Conditions
Aging
Interventions
BAILAMOS™ @home/en casa, ¡En Forma y Fuerte! @home/en casa
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
60 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 8, 2024 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

NCT05138848
View directory record Official record
Conditions
Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change, Amyloid
Interventions
Time in Bed Restriction, Sleep Schedule
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years to 85 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Results available

Cognitive Behavioral Therapy to Improve Work and Wellness in Veterans With Mental Illness

NCT04504903
View directory record Official record
Conditions
Posttraumatic Stress Disorders
Interventions
Cognitive Behavioral Therapy For Work Success (CBTw), Psychoeducation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Hines, Illinois • Indianapolis, Indiana • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Recruiting Phase 2 Interventional

Resilience Enhancement Following Sleep Treatment

NCT07298941
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP), Insomnia
Interventions
Cognitive-behavioral therapy for insomnia (CBTi), CBTi + Savoring Meditation, CBTi + Pain Education
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Results available

Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts

NCT04225624
View directory record Official record
Conditions
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
Interventions
Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Phase 4 Interventional Results available

Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia

NCT00742079
View directory record Official record
Conditions
Schizophrenia
Interventions
D-cycloserine, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fasting ENHANCE Pilot Study

NCT05732935
View directory record Official record
Conditions
Overweight and Obesity, Time Restricted Feeding, Alzheimer Disease
Interventions
Time Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Nicotine Treatment of Cognitive Decline in Down Syndrome

NCT01778946
View directory record Official record
Conditions
Down Syndrome, Mild Cognitive Impairment
Interventions
Low Dose Nicotine (7mg), Moderate Dose Nicotine (14mg)
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
25 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 25, 2026, 6:08 AM EDT
Recruiting Not applicable Interventional

MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI

NCT06138054
View directory record Official record
Conditions
Schizophrenia Spectrum Disorders, Psychotic Affective Disorders, Psychotic Mood Disorders, Homelessness, Ill-Housed Persons
Interventions
MI-CBTech, Mindfulness control
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Phase 1 Interventional

High-Density Direct Current Brain Polarization

NCT00944931
View directory record Official record
Conditions
Healthy Volunteer, HV
Interventions
DC Brain Polarization
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

NCT01206322
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Intranasal insulin, Placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
50 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 26, 2019 · Synced Oct 25, 2026, 6:08 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness

NCT01844726
View directory record Official record
Conditions
Psychiatric Illness, Healthy
Interventions
GLYX-13, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 40 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Non-Invasive Brain Stimulation on Soldiers' Cognitive and Functional Performance

NCT04155333
View directory record Official record
Conditions
Performance Enhancement
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
United States Army Aeromedical Research Laboratory
Federal
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Rucker, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Oct 25, 2026, 6:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline

NCT05907343
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Interventions
Closed-loop TBS, Open-loop TBS
Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Sleep in Veterans and Their CGs

NCT02057068
View directory record Official record
Conditions
Sleep Quality
Interventions
SLEEP-E Dyads Intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 25, 2026, 6:08 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Training to Enhance Cognition in Older Adults

NCT03900702
View directory record Official record
Conditions
Cognitive Enhancement, Aging
Interventions
Gaze-driven training games
Behavioral
Lead sponsor
Jeanne Townsend, PhD
Other
Eligibility
60 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 3, 2019 · Synced Oct 25, 2026, 6:08 AM EDT
Terminated Phase 1 Interventional

Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes

NCT01479998
View directory record Official record
Conditions
Smoking Cessation
Interventions
standard care, standard care plus contingency management
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 25, 2026, 6:08 AM EDT
Enrolling by invitation Not applicable Interventional

Vagal Nerve Stimulation To Enhance Cognition and Learning

NCT07719387
View directory record Official record
Conditions
Vagus Nerve Stimulation, Stroke, Cognitive Assessment, Language Acquisition
Interventions
VNS for Cognition
Device
Lead sponsor
Stony Brook University
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

AI-Based Fidelity Feedback to Enhance CBT

NCT05340738
View directory record Official record
Conditions
Cognitive Behavioral Therapy, Therapy
Interventions
LyssnCBT
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
449 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Completed Not applicable Interventional Results available

Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder

NCT01658150
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
isradipine
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 60 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 25, 2026, 6:08 AM EDT
Not yet recruiting Not applicable Interventional

Digitally Enhanced Cognitive-Behavioral Therapy

NCT07569991
View directory record Official record
Conditions
Depression in Adolescence, Obesity & Overweight, Cognitive-behavioral Therapy, Mobile Health Technology (mHealth), Health Behavior
Interventions
Cognitive-behavioral therapy (CBT), Digital app
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
12 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Personalized Performance Optimization Platform

NCT06979570
View directory record Official record
Conditions
Sensory Science, Performance Assessment, Countermeasure Evaluation, Neurocognitive Function, Psychological Factors
Interventions
AttentivU
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Cambridge, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 25, 2026, 6:08 AM EDT
Recruiting Not applicable Interventional

Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

NCT05236010
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
rTMS, HD-tDCS, Attention Process Training
Device · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 59 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Minneapolis, Minnesota • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 25, 2026, 6:08 AM EDT