Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 23, 2026, 3:07 PM EDT

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Showing 265–288 of 303 matching trials from the live ClinicalTrials.gov search.
Conditions
Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
Interventions
LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)
Dietary Supplement
Lead sponsor
University of Cincinnati
Other
Eligibility
55 Years to 82 Years
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Cincinnati, Ohio
Conditions
Cognitive Dysfunction, Dementia
Interventions
ToolboxDetect
Other
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
35,403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Cognitive Dysfunction
Interventions
adMSC
Biological
Lead sponsor
Paul E Schulz
Other
Eligibility
60 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Conditions
Mild Cognitive Impairment (MCI), Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Dementia, Cognitive Decline
Interventions
Acceptability and Feasibility of Twistle messaging for PDM+ patients
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
3,454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Completed No phase listed Observational Accepts healthy volunteers

Estrogen Use in Protection From Cognitive Decline

NCT00097058
Conditions
Aging, Menopause
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2014
U.S. locations
1
States / cities
Stanford, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults

NCT01264614
Conditions
Cognitive Decline, Dementia, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
Strengthening exercise
Behavioral
Lead sponsor
Union College, New York
Other
Eligibility
55 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Albany, New York
Conditions
Chronic Pain, Physical Activity, Older Adults, Mild Cognitive Impairment
Interventions
MBCT+w, ALED
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Recruiting No phase listed Observational Accepts healthy volunteers

Longevity Metrics AI/ML Development Study

NCT07808619
Conditions
Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome, Cognitive Dysfunction, Frailty, Musculoskeletal Diseases, Activities of Daily Living, Physical Disability, Preventive Health Services, Health Services Accessibility, Diagnostic Techniques and Procedures
Interventions
AIML scored health screening battery
Diagnostic Test
Lead sponsor
Longevity Metrics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2099
U.S. locations
1
States / cities
Boulder, Colorado
Conditions
Mild Cognitive Impairment, Subjective Cognitive Decline
Interventions
Assessments, Neuroimaging volumetric measures, Biofluid samples
Behavioral · Other
Lead sponsor
Ohio State University
Other
Eligibility
50 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Columbus, Ohio
Completed Not applicable Interventional Accepts healthy volunteers

Time Restricted Eating Plus Exercise for Weight Management

NCT05290233
Conditions
Intermittent Fasting, Pre Diabetes, Cognitive Decline
Interventions
TRE + Exercise
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
50 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Frail Elderly, Cognitive Impairment, Mobility Limitation, Depressive Symptoms
Interventions
Tai Ji Quan: Moving for Better Balance, Behavioral Activation, Resource Navigation, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Vermont
Other
Eligibility
65 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Augusta, Maine • Lyme, New Hampshire • Montpelier, Vermont
Conditions
Dementia, Cognition Disorders, Cerebral Ischemic Events
Interventions
Dabigatran Etexilate, Warfarin
Drug
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
65 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Murray, Utah
Conditions
Mild Cognitive Impairment, Subjective Cognitive Decline (SCD)
Interventions
Virtual Reality (VR) sessions
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
55 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Acute Pain on Motor Learning in Young vs Older Adults

NCT05471557
Conditions
Aging, Pain, Acute, Cognitive Decline, Motor Activity
Interventions
pain delivery
Procedure
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 85 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Daily Mixed Spice Consumption on Memory Function

NCT06889961
Conditions
Memory, Cognitive Function
Interventions
Mixed spices, Placebo
Dietary Supplement · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

NCT06217575
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
Interventions
Alpha neurofeedback training, Visual Attention Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Cognitive Decline, Cognitive Impairment
Interventions
TMS
Device
Lead sponsor
San Francisco Neurology and Sleep Center
Other
Eligibility
50 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Behavioral Activation (BA), Supportive Therapy (ST)
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
65 Years and older
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers

Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals

NCT06318377
Conditions
Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet, Healthy
Interventions
Peanut group
Dietary Supplement
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Arlington, Texas
Conditions
Delirium, Postoperative, Cognitive Decline, Dementia
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
70 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Alzheimer Disease
Interventions
Self-Guided Lifestyle Intervention, Structured Lifestyle Intervention
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years to 79 Years
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
6
States / cities
Sacramento, California • Chicago, Illinois • Downers Grove, Illinois + 3 more
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Trial of a Mediterranean Diet Pattern to Prevent Cognitive Decline

NCT02921672
Conditions
Alzheimer's Disease, Cognitive Impairment
Interventions
Mediterranean Diet
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Kansas City, Kansas
Conditions
Cognitive Decline, Cognitive Impairment
Interventions
Walnuts, Simply White Diary-free chocolate bar
Other
Lead sponsor
Ohio State University
Other
Eligibility
40 Years to 75 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
Interventions
Active Brains 1, Active Brains 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts