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Conditions: Sexually Transmitted Diseases, Unsafe Sex, Substance-Related Disorders
Interventions: PACT, TAU; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV Infections, Sexually Transmitted Diseases
Interventions: Peer-oriented intervention, Group cognitive behavioral therapy (CBT); Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years to 74 Years
Enrollment: 746 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Drug Use, Sex Behavior
Interventions: Brief Intervention; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 25 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Turner Syndrome
Interventions: Humatrope; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 4 Years to 20 Years · Female only
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2015
U.S. locations: 9
States / cities: Los Angeles, California • Aurora, Colorado • Hartford, Connecticut + 6 more

Conditions: Aggressive Behavior in Fragile X Syndome
Interventions: SRX246, Placebo; Drug
Lead sponsor: Azevan Pharmaceuticals; Industry
Eligibility: 18 Years to 45 Years · Male only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: Sacramento, California • Chicago, Illinois • Cincinnati, Ohio

Conditions: HIV Infections
Interventions: Discussion Group, Video Discussion Group; Behavioral
Lead sponsor: Gordon Mansergh; Federal
Eligibility: 18 Years and older · Male only
Enrollment: 1,686 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2008
U.S. locations: 6
States / cities: Hollywood, California • San Francisco, California • Chicago, Illinois + 1 more

Conditions: Aortic Regurgitation, Mitral Regurgitation, Aortic Stenosis
Interventions: CMR, Quality of Life Questionnaire; Diagnostic Test · Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Hyperandrogenism
Interventions: Dehydroepiandrosterone (DHEA), Placebo; Dietary Supplement · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Mental Health
Interventions: immi, Control; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 13 Years to 19 Years
Enrollment: 270 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Hypogonadism
Interventions: GnRH antagonist (Acyline); Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 75 Years · Male only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2008
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: HIV Prevention, HIV Pre-exposure Prophylaxis
Interventions: Client Centered Care Coordination; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older · Male only
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Hypothalamic Obesity
Interventions: Setmelanotide; Drug
Lead sponsor: Rhythm Pharmaceuticals, Inc.; Industry
Eligibility: 6 Years to 40 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 5
States / cities: San Diego, California • Gainesville, Florida • Saint Paul, Minnesota + 2 more

Conditions: Autism Spectrum Disorder, Fragile X Syndrome
Interventions: Mismatch negativity; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 15 Years to 35 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Turner Syndrome
Interventions: Not listed
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 6 Years to 22 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: HIV Infection, Human Papillomavirus Infection, Human Papillomavirus-Related Carcinoma
Interventions: Cytology Specimen Collection Procedure, High Resolution Anoscopy with Biopsy, Laboratory Biomarker Analysis, Medical Examination, Physical Examination, Questionnaire Administration; Other · Procedure
Lead sponsor: AIDS Malignancy Consortium; Network
Eligibility: 18 Years and older · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism, GnRH Deficiency
Interventions: gonadotropin releasing hormone (GnRH); Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hiv, Sexual Behavior
Interventions: Peer Navigation and Coping Skills, Treatment as Usual; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 15 Years to 24 Years · Male only
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Polycystic Ovary Syndrome
Interventions: Not listed
Lead sponsor: National Institute of Environmental Health Sciences (NIEHS); NIH
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2000
U.S. locations: 2
States / cities: Research Triangle Park, North Carolina • Richmond, Virginia

Conditions: Human Immunodeficiency Virus (HIV)
Interventions: e-HERO: Ending the HIV Epidemic in Rural Oklahoma; Behavioral
Lead sponsor: Northern Arizona University; Other
Eligibility: 17 Years to 29 Years · Male only
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Flagstaff, Arizona

Conditions: Help-Seeking Behavior, Pre-exposure Prophylaxis Use, Condomless Sex, Risky Health Behavior
Interventions: Moon and Sun Brothers: A Community Prevention Intervention; Behavioral
Lead sponsor: San Francisco State University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: San Francisco, California • Chicago, Illinois

Conditions: Androgen Insensitivity Syndrome, Metabolic Parameters in AIS, CAIS, PAIS and MAIS, Tumor Formation in AIS, CAIS, PAIS and MAIS, Sexual Function AIS, CAIS, PAIS and MAIS
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 8 Years to 99 Years
Enrollment: 650 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2040
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Adolescent Relationship Abuse, Sexual and Gender Minorities
Interventions: FLARE, Resource Guide; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 14 Years and older
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cardiovascular Phenotype, Metabolic Phenotype, Hypertensive Disease, Psychological Phenotype, Audio
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 99 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma, Angiomatoid Fibrous Histiocytoma, Fibrosarcoma NOS, Myxofibrosarcoma, Angiosarcoma, Osteosarcoma, Extraskeletal, Dedifferentiated Liposarcoma, Myxoid Liposarcoma, Pleomorphic Liposarcoma, Myxoid Pleomorphic Liposarcoma, Low Grade Fibromyxoid Sarcoma, Sclerosing Epithelioid Fibrosarcoma, Malignant Tenosynovial Giant Cell Tumor of Soft Tissue, Epithelioid Hemangioendothelioma, Glomus Tumor, Inflammatory Leiomyosarcoma, Leiomyosarcoma, Ossifying Fibromyxoid Tumor, Malignant, Myoepithelioma, Synovial Sarcoma, Epithelioid Sarcoma, Perineurioma, Malignant, Clear Cell Sarcoma, Extraskeletal Myxoid Chondrosarcoma, Granular Cell Tumor, Malignant, Melanotic Malignant Nerve Sheath Tumor, Malignant Peripheral Nerve Sheath Tumor, Perivascular Epithelioid Tumor, Malignant, Intimal Sarcoma, Myoepithelial Carcinoma, Undifferentiated Sarcoma, Pleomorphic Sarcoma, Undifferentiated, Round Cell Sarcoma, Undifferentiated, NTRK-Rearranged Spindle Cell Neoplasm, Phosphaturic Mesenchymal Tumor, Malignant, Round Cell Sarcoma, Well Differentiated Liposarcoma, Giant Cell Tumor of Soft Parts NOS, Low Grade Myofibroblastic Sarcoma, Dermatofibrosarcoma Protuberans, Fibrosarcomatous
Interventions: Surgical resection, Proton beam radiation therapy, Pazopanib, Ifosfamide, Doxorubicin, Selinexor; Procedure · Radiation · Drug
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: Up to 30 Years
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2037
U.S. locations: 7
States / cities: Atlanta, Georgia • Chicago, Illinois • Baton Rouge, Louisiana + 4 more

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Protect and Connect: Couple HIV Prevention for Drug Involved Male Offenders

A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs

Drug Use and Sexual Risk Behaviors Among Emerging Adults in the ER

Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome

Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome

Project MIX: Behavioral Intervention to Reduce Risk Among Substance-Using MSM

Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease

Effects of Androgen Administration on Inflammation in Normal Women

The Digital Wellbeing Project

Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

Client-Centered Care Coordination for Black Men Who Have Sex With Men

Open-Label Study of Setmelanotide in Hypothalamic Obesity

Speech-in-noise Perception in Autism and Fragile X

Risk of Diabetes in Young Turner Syndrome Patients

Incidence of HPV Infection and HPV-Associated Disease in Screening Indian Men Who Have Sex With HIV-Positive Men

Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism

Development of a Telehealth-delivered Peer Navigation and Coping Skills Intervention to Increase PrEP Use in Young Black MSM

Environmental Factors in the Development of Polycystic Ovary Syndrome

e-HERO: Ending the HIV Epidemic in Rural Oklahoma

Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity

Caregiver-Adolescent Dating Violence Prevention Intervention Pilot Trial

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)