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Showing 1–24 of 433 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Colorectal Screening Clear all
Enrolling by invitation Not applicable Interventional

Head to Head Trial of Mailed Cologuard to Mailed FIT

NCT06931860
View directory record Official record
Conditions
Colorectal Cancer Screening, Fecal Immunochemical Test, Multi-target Stool DNA, Colorectal Cancer (CRC)
Interventions
Cologuard, Fecal Immunochemical Test
Diagnostic Test
Lead sponsor
University of California, San Diego
Other
Eligibility
45 Years to 49 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Colorectal Cancer Screening Intervention Study

NCT06424197
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Racial group-targeted messages, Explicit Commitment
Other
Lead sponsor
Oakland University
Other
Eligibility
45 Years to 80 Years
Enrollment
799 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jul 23, 2026, 9:05 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Demonstrating Effective Salvage of Inadequate Colonoscopies

NCT05585879
View directory record Official record
Conditions
Colorectal Screening
Interventions
Pure-Vu EVS
Device
Lead sponsor
Motus GI Medical Technologies Ltd
Industry
Eligibility
40 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementing Fit Kit Colorectal Cancer (CRC) Screening in High Risk Populations

NCT04848051
View directory record Official record
Conditions
Colorectal Cancer
Interventions
CRC screening reminder, CRC Reminder & Short message, CRC Reminder and Navigation Program, CRC Reminder & CRC education
Behavioral
Lead sponsor
Yale University
Other
Eligibility
50 Years to 74 Years
Enrollment
3,127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 2, 2023 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using Behavioral Science to Improve Colorectal Cancer Screening Rates With Mailed FIT Kits

NCT04746469
View directory record Official record
Conditions
Colorectal Cancer Screening
Interventions
Delayed automated phone call
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years to 75 Years
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial

NCT07107152
View directory record Official record
Conditions
Colorectal Cancer Control and Prevention
Interventions
single GPT generated message, AI Chatbot, Expert-Written Patient Materials
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
45 Years to 75 Years
Enrollment
915 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 23, 2026, 9:05 AM EDT
Completed No phase listed Observational

Colorectal Cancer Screening for Cancer Survivors

NCT00982059
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Colonoscopic examination
Other
Lead sponsor
University Health Network, Toronto
Other
Eligibility
35 Years to 49 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 30, 2018 · Synced Jul 23, 2026, 9:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Improving Colorectal Cancer Screening in Racially Diverse Zip Codes Using Navigation and Machine Learning (PCSNaP)

NCT05383976
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Machine Learning Algorithm with Existing Penn Medicine CRC Patient Navigation Program
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Not listed
Enrollment
385 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Early Detection of Advanced Adenomas and Colorectal Cancer

NCT06342440
View directory record Official record
Conditions
Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal Disorders, Colorectal Dysplasia, Colorectal Cancer Stage I, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Cancer Stage IV, Colorectal Neoplasms Malignant, Colorectal Serrated Adenocarcinoma, Colorectal Adenoma With Severe Dysplasia, Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Moderate Dysplasia, Colorectal Adenoma and Carcinoma 1, Colorectal Adenomatous Polyp, Colorectal Adenocarcinoma Metastatic in the Liver
Interventions
DENEB
Diagnostic Test
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2028
U.S. locations
2
States / cities
Monrovia, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Results available

Use of Telehealth In-home Messaging to Improve GI (Gastrointestinal) Endoscopy Completion Rates

NCT00310362
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Use of Interactive Voice Response (IVR) system to improve adherence to GI appointments and prep procedures
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
3,610 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Jul 23, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities

NCT05447923
View directory record Official record
Conditions
Colorectal Carcinoma
Interventions
Educational Intervention, Fecal Immunochemical Test, Patient Navigation, Questionnaire Administration
Other · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
45 Years and older
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2030
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Completed No phase listed Observational Results available

Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC

NCT05510908
View directory record Official record
Conditions
HIV-Associated Malignant Neoplasm, HIV Infections, Cancer, AIDS Related Lymphoma, AIDS-related Kaposi Sarcoma, AIDS-Related Malignancy, Anal Cancer, HPV-Related Malignancy
Interventions
Non-Interventional, Non-Interventional Follow-up
Other
Lead sponsor
AIDS Malignancy Consortium
Network
Eligibility
18 Years and older
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
15
States / cities
La Jolla, California • Washington D.C., District of Columbia • Miami, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Screen to Save: NCI Colorectal Cancer Outreach & Screening Initiative

NCT05064410
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Educational Intervention
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
45 Years to 75 Years
Enrollment
188 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stool DNA to Improve Colorectal Cancer Screening Among Alaska Native People

NCT04336397
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Multi-target stool DNA test, Colonoscopy
Diagnostic Test
Lead sponsor
Alaska Native Tribal Health Consortium
Other
Eligibility
45 Years to 75 Years
Enrollment
2,029 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bethel, Alaska
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Jul 23, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional

Community Partnership for Telehealth Solutions to Convey Information and Enhance Care

NCT06542835
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Video text message, In-clinic CRC screening promotion, Mailed FIT, Social needs navigation, Reminders
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
45 Years to 64 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT of Automated Telephone Outreach to Improve Colorectal Cancer Screening

NCT00792285
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Automated Telephone Outreach with Speech Recognition
Behavioral
Lead sponsor
Harvard Pilgrim Health Care
Other
Eligibility
50 Years to 64 Years
Enrollment
80,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 16, 2008 · Synced Jul 23, 2026, 9:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test

NCT03688906
View directory record Official record
Conditions
Colo-rectal Cancer, Cancer Colon, Cancer, Rectum, Neoplasms,Colorectal, Polyps, Polyp of Colon, Adenoma, Adenoma Colon
Interventions
Not listed
Lead sponsor
Freenome Holdings Inc.
Industry
Eligibility
18 Years and older
Enrollment
3,275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
29
States / cities
Huntsville, Alabama • Chandler, Arizona • Tucson, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jul 23, 2026, 9:05 AM EDT
Not listed No phase listed Observational

Improving Cancer Screening and Prevention During the COVID-19 Pandemic in Underserved Populations of Rhode Island

NCT04587258
View directory record Official record
Conditions
Breast Cancer, Colorectal Cancer, Covid19
Interventions
Informational videos and social media campaigns encouraging cancer screening.
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pawtucket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 13, 2020 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Implementation Intentions to Promote Colon Cancer Screening in Rural Primary Care Practice

NCT00599378
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Implementation Intentions-based telephone counseling
Behavioral
Lead sponsor
Kimberly Engelman, PhD
Other
Eligibility
50 Years and older
Enrollment
373 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2013 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of Colorectal Cancer Screening Options

NCT05987709
View directory record Official record
Conditions
Colon Cancer
Interventions
GuardantSHIELD Blood Test
Diagnostic Test
Lead sponsor
Kaiser Permanente
Other
Eligibility
45 Years to 75 Years
Enrollment
2,004 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Prospective Randomized Controlled Trial Comparing Water and Air Colonoscopy in a Community Based Setting

NCT01729416
View directory record Official record
Conditions
Tubular Adenoma, Colon Cancer, Hyperplastic Polyp
Interventions
Water Exchange Colonoscopy, Air Colonoscopy
Other
Lead sponsor
University of California, Davis
Other
Eligibility
50 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Elk Grove, California
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Jul 23, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Computer Aided Detection of Polyps in Colonoscopy

NCT04754347
View directory record Official record
Conditions
Colorectal Polyp
Interventions
Computer Aided Detection device
Device
Lead sponsor
Iterative Scopes, Inc
Industry
Eligibility
40 Years and older
Enrollment
1,472 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
5
States / cities
Boston, Massachusetts • Cambridge, Massachusetts • Plymouth, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2021 · Synced Jul 23, 2026, 9:05 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Study to Evaluate the Diagnostic Performance of of MAGENTIQ-COLO During Colonoscopy.

NCT06568523
View directory record Official record
Conditions
Screening Colonoscopy, Surveillance Colonoscopy
Interventions
MAGENTIQ-COLO.
Diagnostic Test
Lead sponsor
Magentiq Eye LTD
Industry
Eligibility
45 Years to 80 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland • Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Jul 23, 2026, 9:05 AM EDT
Not yet recruiting Not applicable Interventional

Colorectal Cancer Screening in the Homeless

NCT07220018
View directory record Official record
Conditions
Colorectal Cancer
Interventions
mHealth for Colorectal cancer screening in Homeless Persons, Control SMS Messages
Behavioral · Other
Lead sponsor
George Washington University
Other
Eligibility
45 Years to 75 Years
Enrollment
588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 23, 2026, 9:05 AM EDT