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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Compartment Syndrome Clear all
Not listed Not applicable Interventional

Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome

NCT04671173
View directory record Official record
Conditions
Acute Compartment Syndrome
Interventions
Measurement of the Intra-Compartmental Pressure with the MY01 device
Device
Lead sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Minneapolis, Minnesota • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Diagnosing Compartment Syndrome With SHAPE vs Elastography

NCT05247541
View directory record Official record
Conditions
Chronic Exertional Compartment Syndrome
Interventions
Definity
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 5, 2026, 3:13 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Botulinum for Chronic Exertional Compartment Syndrome

NCT03339921
View directory record Official record
Conditions
Chronic Exertional Compartment Syndrome
Interventions
Botulinum toxin injections for chronic compartment syndrome, surgical fasciotomy for chronic compartment syndrome
Drug · Procedure
Lead sponsor
375th Medical Group, Scott Air Force Base
Federal
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Scott Air Force Base, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Sep 5, 2026, 3:13 PM EDT
Not listed No phase listed Observational

Utilization of High Frequency Ultrasound to Diagnose Chronic Exertional Compartment Syndrome

NCT03736174
View directory record Official record
Conditions
Chronic Exertional Compartment Syndrome
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
13 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Sep 5, 2026, 3:13 PM EDT
Recruiting Not applicable Interventional

Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients

NCT05830721
View directory record Official record
Conditions
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
Interventions
MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
Device · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A

NCT05466539
View directory record Official record
Conditions
Compartment Syndrome of Leg
Interventions
AbobotulinumtoxinA, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia • Brookhaven, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Phase 1 Interventional Results available

Body Compartment PK for New HIV Pre-exposure Prophylaxis Modalities

NCT02985996
View directory record Official record
Conditions
HIV Infections
Interventions
Truvada, Genvoya
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 49 Years · Male only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Sep 5, 2026, 3:13 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Muscle Oxygenation and Skin Pigmentation

NCT00747162
View directory record Official record
Conditions
Muscle Oxygenation, Skin Pigmentation
Interventions
Measure of muscle oxygenation, Skin pigmentation determination
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 26, 2013 · Synced Sep 5, 2026, 3:13 PM EDT
Not listed No phase listed Observational

The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome

NCT01171638
View directory record Official record
Conditions
Acute Compartment Syndrome
Interventions
Near infrared spectroscopy (NIRS)
Device
Lead sponsor
J&M Shuler
Industry
Eligibility
15 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced Sep 5, 2026, 3:13 PM EDT
Recruiting No phase listed Observational

Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?

NCT06512870
View directory record Official record
Conditions
Compartment Syndromes
Interventions
Near infrared spectroscopy (NIRS)
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Sep 5, 2026, 3:13 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity

NCT01283451
View directory record Official record
Conditions
Acute Compartment Syndrome
Interventions
Muscle contraction
Behavioral
Lead sponsor
J&M Shuler
Industry
Eligibility
18 Years to 75 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 5, 2026, 3:13 PM EDT
Terminated Not applicable Interventional Results available

Closure of Fasciotomy Wounds: A Prospective, Observational Study of a Continuous External Tissue Expander

NCT01171534
View directory record Official record
Conditions
Wounds and Injuries, Compartment Syndrome
Interventions
DermaClose fasciotomy closure, Vessel loop
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 28, 2018 · Synced Sep 5, 2026, 3:13 PM EDT
Terminated Not applicable Interventional

Study to Determine the Utility of Wound Vacuum Assisted Closure (VAC) Compared to Conventional Saline Dressing Changes

NCT00121537
View directory record Official record
Conditions
Wounds, Compartment Syndromes
Interventions
Wound Care -Wound Vacuum Assisted Closure (VAC), Wound Care - Wet to Dry Dressing Changes
Device · Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 5, 2026, 3:13 PM EDT
Completed No phase listed Observational Results available

Measuring Intraabdominal Pressure, Lactic Acid, and Urine Output

NCT05070572
View directory record Official record
Conditions
Intra-Abdominal Hypertension, Inguinal Hernia
Interventions
Accuryn Monitoring System
Device
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Timeline
2021 – 2023
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Not applicable Interventional

Predicting Acute Compartment Syndrome (PACS)

NCT01561261
View directory record Official record
Conditions
Acute Compartment Syndrome
Interventions
Continuous tissue perfusion monitoring by near-infrared spectroscopy (NIRS) and intramuscular pressure (IMP)
Other
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
7
States / cities
Denver, Colorado • Baltimore, Maryland • Minneapolis, Minnesota + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 5, 2026, 3:13 PM EDT
Terminated Phase 4 Interventional Results available

Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome

NCT05006417
View directory record Official record
Conditions
Compartment Syndrome of Leg
Interventions
Botox
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Sep 5, 2026, 3:13 PM EDT
Completed No phase listed Observational

Physiologic Signals and Signatures With the Accuryn Monitoring System (The Accuryn Registry)

NCT04585555
View directory record Official record
Conditions
Acute Kidney Injury, Abdominal Compartment Syndrome, Intraabdominal Hypertension, Cardiovascular Surgery
Interventions
Accuryn Monitoring System
Device
Lead sponsor
Potrero Medical
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Sep 5, 2026, 3:13 PM EDT
Not listed No phase listed Observational

Evaluating the Diagnostic Performance of ACS Using NIRS in Traumatized Lower Extremities

NCT03604029
View directory record Official record
Conditions
Compartment Syndrome of Leg
Interventions
Near Infrared Spectroscopy
Device
Lead sponsor
Nonin Medical, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Sep 5, 2026, 3:13 PM EDT
Withdrawn No phase listed Observational

Collective Accuryn Physiologic Signals and Signatures

NCT03817281
View directory record Official record
Conditions
Critical Illness, Acute Kidney Injury, Sepsis, Septic Shock, Abdominal Compartment Syndrome
Interventions
Accuryn Monitoring System
Device
Lead sponsor
Potrero Medical
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Detecting Compartment Syndrome Pain in the Presence of Regional Anesthesia in Healthy Volunteers

NCT04113954
View directory record Official record
Conditions
Compartment Syndrome of Leg, Healthy
Interventions
Mepivacaine Injection
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 5, 2026, 3:13 PM EDT
Recruiting Phase 4 Interventional

Preoperative BOTOX® Injection for Large Ventral Hernia Repair

NCT07220382
View directory record Official record
Conditions
Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome, Hernia Surgery, Hernia, Hernia Incisional
Interventions
OnabotulinumtoxinA Injection, Saline (placebo) Injection, OnabotulinumtoxinA, 0.9 % Normal Saline, Open Ventral Hernia Repair
Procedure · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 5, 2026, 3:13 PM EDT
Completed Phase 2 Interventional Results available

Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS)

NCT04409600
View directory record Official record
Conditions
Chronic Exertional Compartment Syndrome
Interventions
Supervised Gait Retraining, Home Based Gait Retraining, Saline Injection, Botulinum Toxin Injection
Behavioral · Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
4
States / cities
Bethesda, Maryland • Fort Bragg, North Carolina • Killeen, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 5, 2026, 3:13 PM EDT
Recruiting Not applicable Interventional

Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter

NCT06876896
View directory record Official record
Conditions
Intra-Abdominal Hypertension
Interventions
Accuryn Foley catheter device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 5, 2026, 3:13 PM EDT
Completed No phase listed Observational

Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome

NCT01077934
View directory record Official record
Conditions
Compartment Syndrome
Interventions
near-infrared spectroscopy
Device
Lead sponsor
J&M Shuler
Industry
Eligibility
13 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 26, 2015 · Synced Sep 5, 2026, 3:13 PM EDT