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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Complex Regional Pain Syndrome (CRPS) Clear all
Completed No phase listed Observational

Forward Looking InfraRed Imaging and Severity Score in Complex Regional Pain Syndrome

NCT05852210
View directory record Official record
Conditions
CRPS (Complex Regional Pain Syndromes)
Interventions
Infrared Imaging
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 21, 2026, 3:59 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

"Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"

NCT03616262
View directory record Official record
Conditions
Complex Regional Pain Syndrome
Interventions
Botox + Lidocaine, Lidocaine alone
Drug
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 5, 2018 · Synced Jul 21, 2026, 3:59 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia

NCT02987855
View directory record Official record
Conditions
RSD (Reflex Sympathetic Dystrophy), CRPS - Complex Regional Pain Syndrome Type I, Fibromyalgia
Interventions
Lipoaspiration, ADcSVF isolation, Normal Saline IV
Procedure
Lead sponsor
Healeon Medical Inc
Industry
Eligibility
16 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Stevensville, Montana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Not applicable Interventional

Effectiveness of Virtual Reality in Hand Therapy

NCT05188040
View directory record Official record
Conditions
Distal Radius Fracture, Chronic Regional Pain Syndrome, Flexor Tendon Rupture
Interventions
Virtual Reality Exercises
Other
Lead sponsor
Timothy Uhl
Other
Eligibility
18 Years to 99 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Georgetown, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Phase 4 Interventional

A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions

NCT00904202
View directory record Official record
Conditions
Postherpetic Neuralgia, Diabetic Neuropathy, Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, HIV Neuropathy, Idiopathic Sensory Neuropathy, Peripheral Neuropathy
Interventions
Placebo Capsules + Placebo Patch, Placebo capsules + Lidoderm®, Gabapentin + Placebo, Gabapentin + Lidoderm®, Gabapentin 300 mg capsules 1800 mg/day + placebo patch, Gabapentin 1800 mg/day + Lidoderm patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
7
States / cities
Birmingham, Alabama • Hueytown, Alabama • Phoenix, Arizona + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Jul 21, 2026, 3:59 PM EDT
Completed No phase listed Observational

Association Between Focal Dystonia and Complex Regional Pain Syndrome

NCT00595439
View directory record Official record
Conditions
Focal Dystonia, Peripheral Nervous System Disease
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 3:59 PM EDT
Withdrawn No phase listed Observational

Predicting Pain Exacerbations in Children With Complex Regional Pain Syndrome (CRPS)

NCT06337526
View directory record Official record
Conditions
Complex Regional Pain Syndromes
Interventions
Apple Watch v8
Device
Lead sponsor
Stanford University
Other
Eligibility
8 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Not applicable Interventional Results available

Effects of Pennsaid on Clinical Neuropathic Pain

NCT01508676
View directory record Official record
Conditions
Neuralgia, Postherpetic Neuralgia, Reflex Sympathetic Dystrophy, Complex Regional Pain Syndrome (CRPS)
Interventions
Pennsaid, Placebo (2.3% DMSO solution)
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 5, 2017 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Phase 3 Interventional Results available

Safety of Intravenous Neridronic Acid in CRPS

NCT02972359
View directory record Official record
Conditions
Complex Regional Pain Syndrome
Interventions
Neridronic acid
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years and older
Enrollment
580 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
42
States / cities
Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 35 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica

NCT02753101
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Sciatica
Interventions
[18F]-FTC-146
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2018 · Synced Jul 21, 2026, 3:59 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety of Intravenous Neridronic Acid in CRPS

NCT03530345
View directory record Official record
Conditions
Complex Regional Pain Syndrome (CRPS)
Interventions
Neridronic acid 100 mg, Placebo
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years and older
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
39
States / cities
Huntsville, Alabama • Mobile, Alabama • Peoria, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Jul 21, 2026, 3:59 PM EDT
Terminated No phase listed Observational Results available

Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome

NCT03794024
View directory record Official record
Conditions
Complex Regional Pain Syndrome
Interventions
The Nuvectra Algovita Dorsal Column Spinal Cord Stimulator, The Axium Neurostimulator System
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Not applicable Interventional Results available

Intraoperative Neuromonitoring Recording With a Novel SCS Paddle

NCT05045625
View directory record Official record
Conditions
Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
Interventions
HD Study Electrode
Device
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Jul 21, 2026, 3:59 PM EDT
Terminated Phase 1 Interventional

Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain.

NCT02321566
View directory record Official record
Conditions
Trigeminal Neuralgia (Burchiel Type I), Trigeminal Neuralgia (Burchiel Type II), Trigeminal Neuropathic Pain, Trigeminal Deafferentation Pain, Complex Regional Pain Syndrome (Types I and II, Involving the Upper Extremity), Glossopharyngeal Neuralgia, Upper Extremity Pain Due to Deafferentation of the Cervical Spine, Central Pain Syndromes
Interventions
Epidural Motor Cortex Stimulation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Jul 21, 2026, 3:59 PM EDT
Completed No phase listed Observational

Susceptibility to Chronic Post-Traumatic Extremity Pain

NCT00672711
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Royal Oak, Michigan • Troy, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 3, 2020 · Synced Jul 21, 2026, 3:59 PM EDT
Not yet recruiting Not applicable Interventional

Empowered Relief for Caregivers

NCT07636980
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Neuropathic Pain, Complex Regional Pain Syndromes (CRPS), Abdominal Pain (AP)
Interventions
Empowered Relief for Caregivers (ER-CY)
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Not applicable Interventional

Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures

NCT02957240
View directory record Official record
Conditions
Musculoskeletal Pain, Fractures, Closed, Distal Radius Fracture, Complex Regional Pain Syndromes
Interventions
Standard Care, Motor Representation Techniques
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
55 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Jul 21, 2026, 3:59 PM EDT
Recruiting No phase listed Observational

Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients

NCT05777889
View directory record Official record
Conditions
Complex Regional Pain Syndromes
Interventions
Forward Looking InfraRed Camera
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jul 21, 2026, 3:59 PM EDT
Withdrawn Not applicable Interventional

TNF-alpha Inhibition in CRPS: A Randomized Controlled Trial

NCT02031211
View directory record Official record
Conditions
CRPS, Chronic Regional Pain Syndrome
Interventions
Etanercept, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 17 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Jul 21, 2026, 3:59 PM EDT
Not listed Phase 3 Interventional

CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1

NCT02504008
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Reflex Sympathetic Dystrophy
Interventions
AXS-02 (oral zoledronate), Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
29
States / cities
Tucson, Arizona • Hot Springs, Arkansas • Encinitas, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2018 · Synced Jul 21, 2026, 3:59 PM EDT
Recruiting Phase 1 Interventional

The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome

NCT06393101
View directory record Official record
Conditions
Complex Regional Pain Syndrome
Interventions
BRC-002, BRC-002 Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2024 · Synced Jul 21, 2026, 3:59 PM EDT
Completed No phase listed Observational

Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes

NCT05491499
View directory record Official record
Conditions
Chronic Pain Syndrome, Fibromyalgia, Chronic Headache Disorder, Functional Abdominal Pain Syndrome, Complex Regional Pain Syndromes
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Jul 21, 2026, 3:59 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Role of the Gut Microbiome in Complex Regional Pain Syndrome

NCT03612193
View directory record Official record
Conditions
Complex Regional Pain Syndromes
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Jul 21, 2026, 3:59 PM EDT
Completed Phase 2 Interventional

A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS)

NCT00067743
View directory record Official record
Conditions
Complex Regional Pain Syndrome (RSD)
Interventions
Lenalidomide
Drug
Lead sponsor
Celgene Corporation
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
6
States / cities
La Jolla, California • Baltimore, Maryland • Chapel Hill, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2008 · Synced Jul 21, 2026, 3:59 PM EDT