Independent directory Public ClinicalTrials.gov records United States
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Showing 1–24 of 485 matching trials from the live ClinicalTrials.gov search.
Conditions
Head Injury Trauma, Traumatic Brain Injury, Mild
Interventions
Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
Diagnostic Test
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
6
States / cities
Sylmar, California • Torrance, California • Clinton Township, Michigan + 2 more
Completed No phase listed Observational Accepts healthy volunteers

Brain Injury Outcomes (BIO) Study

NCT00724607
Conditions
Brain Concussion, Posttraumatic Stress Disorder, Dementia
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 59 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Recruiting Not applicable Interventional

GyroStim for Post Concussion Syndrome

NCT07527663
Conditions
Post Concussion Syndrome
Interventions
Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
Device · Other
Lead sponsor
Neuroscience Group
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Appleton, Wisconsin
Not listed Phase 2 Interventional Accepts healthy volunteers

Acute Concussion and Melatonin

NCT04731974
Conditions
Concussion, Mild, Concussion, Brain, Pediatric ALL
Interventions
Melatonin 3 MG, Placebo
Drug · Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
12 Years to 18 Years
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Terminated Phase 2 Interventional Results available

OPTIMA-TBI Pilot Study

NCT03345550
Conditions
Mild Traumatic Brain Injury
Interventions
Omega-3 Polyunsaturated Fatty Acids (Fish Oil 1000 mg (contains 500 mg DHA & 100 mg EPA)) or placebo capsules., Placebo - Cap
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Head Impact Exposure in Hawaii High School Football

NCT04020874
Conditions
Head Trauma, Cognitive Change, Confidence, Self, Sports Injuries in Children
Interventions
HuTT-2x, HuTT-4x
Behavioral
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
14 Years to 19 Years
Enrollment
496 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Honolulu, Hawaii
Conditions
Concussion, Mild, Traumatic Brain Injury
Interventions
Clinical implementation strategies
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
5,831 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Conditions
Concussion, Mild, Mild Traumatic Brain Injury (mTBI), Psychological Health
Interventions
Acceptance and Commitment Therapy Integrated Rehabilitation (ACT), Usual Care Rehabilitation
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 49 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Fort Hood, Texas
Conditions
Concussion; Syndrome
Interventions
Compass Course
Behavioral
Lead sponsor
Mary Radomski
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Concussion, Mild, Sport Injury
Interventions
Aerobic (treadmill) Exercise, Dynamic (Agility) Exercise
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 35 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Traumatic Brain Injury
Interventions
Internet-based Interacting Together Everyday: Recovery After Childhood TBI, Internet Resources Comparison
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
3 Years to 9 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Conditions
Concussion
Interventions
Nautilus BrainPulse Recording
Device
Lead sponsor
Jan Medical, Inc.
Industry
Eligibility
10 Years to 25 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
4
States / cities
Fort Lauderdale, Florida • Munster, Indiana • Baton Rouge, Louisiana + 1 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Movement Assessment for Concussion Management

NCT02776904
Conditions
Healthy Athlete
Interventions
Immediate Post-concussion Assessment and Cognitive Testing, Gait with single and dual task, Y-Balance test, Psychomotor Vigilance Task
Other
Lead sponsor
University of Arkansas
Other
Eligibility
14 Years to 18 Years
Enrollment
327 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Concussion, Mild
Interventions
Soccer heading
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 26 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bloomington, Indiana
Terminated No phase listed Observational Accepts healthy volunteers

Effects of Multiple Concussions in Retired NHL Players

NCT02746523
Conditions
Cognitive Deficits, Proprioceptive Disorders
Interventions
Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS), Depression Scale, Cognitive Assessment
Other · Genetic
Lead sponsor
New York Institute of Technology
Other
Eligibility
40 Years to 80 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Completed Not applicable Interventional Results available

Yoga and Female Concussion

NCT07170488
Conditions
Concussion Mild
Interventions
Yoga, Yoga for wait list control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers

Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial

NCT02988596
Conditions
Concussion, Brain
Interventions
Multidimensional Active Rehabilitation, Enhanced Graded Exertion
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
13 Years to 99 Years
Enrollment
251 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
7
States / cities
Durham, North Carolina • Elon, North Carolina • Hillsborough, North Carolina + 4 more
Conditions
Mild Traumatic Brain Injury, Dizziness
Interventions
Vestibular Rehabilitation Therapy (VRT)
Behavioral
Lead sponsor
Mountain Home Research & Education Corporation
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Tampa, Florida • Durham, North Carolina • Mountain Home, Tennessee
Terminated Not applicable Interventional Results available

TBI MR Study 3 Houston Methodist

NCT02218216
Conditions
Traumatic Brain Injury
Interventions
MRI Diagnostic
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
15 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Houston, Texas
Conditions
Traumatic Brain Injury, Vision Difficulty
Interventions
neuro vision rehabilitation
Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 55 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Brain Concussion, Vestibular Disorder, Cognition Disorder, Mild Traumatic Brain Injury
Interventions
Praxis, Supervised cardiovascular exercise
Device · Behavioral
Lead sponsor
BlueHalo
Industry
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Conditions
Post Concussion Symptoms
Interventions
ALTIUS® daily disposable performance-tinted contact lenses
Device
Lead sponsor
Southern College of Optometry
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Memphis, Tennessee
Conditions
Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment
Interventions
active tDCS and cognitive training intervention, sham tDCS and cognitive training intervention
Combination Product
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 55 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Diego, California
Conditions
Concussion, Intermediate
Interventions
magnesium and riboflavin supplement
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 40 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia