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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Consciousness Disorders Clear all
Completed Phase 3 Interventional Results available

Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.

NCT02809131
View directory record Official record
Conditions
Sick Sinus Syndrome, Complete Heart Block, Syncope, Chronic Systolic Heart Failure
Interventions
polymixin/bacitracin, cephalexin, or levofloxacin, or clindamycin, Saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Addressing Fear and Risk of Vasovagal Reactions Among High School Donors

NCT03835299
View directory record Official record
Conditions
Blood Donors
Interventions
Fear Intervention
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
16 Years and older
Enrollment
4,035 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Jul 22, 2026, 5:06 PM EDT
Recruiting No phase listed Observational

An Ethical Approach to Detecting Covert Consciousness

NCT05010265
View directory record Official record
Conditions
Disorder of Consciousness
Interventions
Clinician Questionnaire, Semi Structured Interviews
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jul 22, 2026, 5:06 PM EDT
Not listed Phase 4 Interventional

Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV

NCT01456481
View directory record Official record
Conditions
Vasovagal Syncope
Interventions
midodrine hydrochloride, matching placebo
Drug
Lead sponsor
Dr. Bob Sheldon
Other
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2024
U.S. locations
2
States / cities
Minneapolis, Minnesota • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reconstructing Consciousness and Cognition

NCT01911195
View directory record Official record
Conditions
Postoperative Cognitive Dysfunction
Interventions
ISOFLURANE- Experimental Arm, Control Group: Cognitive Testing
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
20 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
3
States / cities
Ann Arbor, Michigan • St Louis, Missouri • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2024 · Synced Jul 22, 2026, 5:06 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

fNIRS for Disorders of Consciousness

NCT07485361
View directory record Official record
Conditions
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions
Functional Near-Infrared Spectroscopy Monitoring
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 22, 2026, 5:06 PM EDT
Not listed Phase 1Phase 2 Interventional

A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness

NCT02696512
View directory record Official record
Conditions
Brain Injury
Interventions
Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation, Standard of Care
Drug · Device · Dietary Supplement + 1 more
Lead sponsor
International Brain Research Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Edison, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 1, 2016 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness

NCT02025439
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
rTMS, Amantadine
Device · Drug
Lead sponsor
Edward Hines Jr. VA Hospital
Federal
Eligibility
18 Years to 64 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 23, 2020 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

NCT04217551
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
Interventions
Therapeutic Hypothermia
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
76
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 22, 2026, 5:06 PM EDT
Terminated Not applicable Interventional Results available

Thalamic Low Intensity Focused Ultrasound in Brain Injury

NCT02522429
View directory record Official record
Conditions
Consciousness Disorders, Brain Injuries
Interventions
Low Intensity Focused Ultrasound Device
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Novel Helmet Design in Patients With Seizures

NCT03443388
View directory record Official record
Conditions
Drug Resistant Epilepsy, Drop Seizures, Generalized Tonic Clonic Seizure, Complex Partial Seizure, Fall Due to Seizure
Interventions
Hövding inflatable helmet
Device
Lead sponsor
Michael A. Gelfand, MD, PhD
Other
Eligibility
18 Years to 60 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment

NCT01372254
View directory record Official record
Conditions
Cigarette Smoking, Drug Use
Interventions
Standard Treatment, BAD-AS, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Jul 22, 2026, 5:06 PM EDT
Not yet recruiting No phase listed Observational

Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury

NCT07326059
View directory record Official record
Conditions
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter, Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With Persistent Cognitive Deficits
Interventions
MUSE Stem Cell Therapy
Biological
Lead sponsor
Healing Hope International
Other
Eligibility
6 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2028 – 2036
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Syncope Decision Aid for Emergency Care

NCT02971163
View directory record Official record
Conditions
Syncope
Interventions
SynDA
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
30 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 25, 2020 · Synced Jul 22, 2026, 5:06 PM EDT
Terminated No phase listed Observational

Clinical Autonomic Disorders: A Training Protocol

NCT02154009
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope, Postural Tachycardia Syndrome
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
2 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Jul 22, 2026, 5:06 PM EDT
Enrolling by invitation Not applicable Interventional

mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness

NCT06426602
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
mindBEAGLE daily device use
Device
Lead sponsor
Amy Wagner
Other
Eligibility
16 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 22, 2026, 5:06 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury

NCT06083441
View directory record Official record
Conditions
Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury, Acute Brain Injury
Interventions
SeeMe, Coma Recovery Scale-Revised (CRS-R)
Diagnostic Test
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Jul 22, 2026, 5:06 PM EDT
Active, not recruiting Not applicable Interventional

Intervention to Change Affect Recognition and Empathy

NCT05636020
View directory record Official record
Conditions
Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes, Concussion With Brief Loss of Consciousness, Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With Loss of Consciousness, Traumatic Brain Injury With Prolonged Loss of Consciousness, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter, Traumatic Brain Injury With No Loss of Consciousness, Traumatic Brain Injury With Open Intracranial Wound, Traumatic Brain Injury With Moderate Loss of Consciousness
Interventions
ICARE Treatment
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 22, 2026, 5:06 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Resting State fMRI in Disorders of Consciousness

NCT05463029
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Jul 22, 2026, 5:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

LUX-Dx Insertable Cardiac Monitor Remote Programming and Performance Study

NCT04732728
View directory record Official record
Conditions
Atrial Fibrillation, Syncope, Cryptogenic Stroke
Interventions
Not listed
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
727 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
24
States / cities
Huntsville, Alabama • Flagstaff, Arizona • Jonesboro, Arkansas + 21 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Jul 22, 2026, 5:06 PM EDT
Completed No phase listed Observational

The Simple ECG Monitoring Trial (Comparison of a Novel Recording System With a Standard Holter Monitor)

NCT01382953
View directory record Official record
Conditions
Syncope, Pre-syncope, Atrial Fibrillation, Supraventricular Tachycardia
Interventions
Standard Holter/Investigational patch
Device
Lead sponsor
Seattle Institute for Cardiac Research
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
Chicago, Illinois • Enumclaw, Washington
Source: ClinicalTrials.gov public record
Updated Jan 9, 2012 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression

NCT00042575
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Duloxetine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002
U.S. locations
9
States / cities
Trumbull, Connecticut • Lafayette, Indiana • Gaithersburg, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2006 · Synced Jul 22, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Control Training for Depression

NCT01454141
View directory record Official record
Conditions
Depression
Interventions
Cognitive Control Training, Peripheral Vision Task
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 22, 2026, 5:06 PM EDT
Recruiting Phase 2 Interventional

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

NCT07130786
View directory record Official record
Conditions
Seizures, Primary Motor Cortex, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), Brain Metastases, Adult, Brain Metastases From Extra-cranial Solid Tumors
Interventions
Levetiracetam (Keppra)
Drug
Lead sponsor
Ayal A. Aizer, MD
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jul 22, 2026, 5:06 PM EDT