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Conditions: Primary Sclerosing Cholangitis, Liver Transplant, Complications, PSC, Biliary Strictures
Interventions: Fenofibrate (drug), Blood draw for the laboratory assessment, MRI using a hepatobiliary phase contrast agent (Gd-EOB-DPTA); Drug · Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Scottsdale, Arizona

Conditions: Biliary Stricture
Interventions: MGH Optical Frequency Domain Imaging (OFDI); Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Superficial Femoral Artery Stenosis, Superficial Femoral Artery Occlusion, Claudication, Rest Pain
Interventions: Open Bypass Surgery, Angioplasty and Stenting; Procedure
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Lumbar Spinal Stenosis
Interventions: Stabilimax NZ® Dynamic Spine Stabilization System; Device
Lead sponsor: Applied Spine Technologies; Industry
Eligibility: 21 Years and older
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 19
States / cities: Phoenix, Arizona • Los Angeles, California • Oceanside, California + 16 more

Conditions: Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Mitochondrial Cardiomyopathy, Noncompaction Cardiomyopathy, Restrictive Cardiomyopathy
Interventions: Not listed
Lead sponsor: University of California, Irvine; Other
Eligibility: Not listed
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 1
States / cities: Irvine, California

Conditions: Unstable Angina, Coronary Atherosclerosis, Coronary Restenosis
Interventions: Serine proteinase-1 (Serp-1); Drug
Lead sponsor: Viron Therapeutics Inc; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 3
States / cities: Washington D.C., District of Columbia • Gainesville, Florida • Grand Rapids, Michigan

Conditions: Hypertrophic Cardiomyopathy
Interventions: None - this is an observational study; Other
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years to 65 Years
Enrollment: 2,750 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2025
U.S. locations: 17
States / cities: New Haven, Connecticut • Chicago, Illinois • Baltimore, Maryland + 10 more

Conditions: Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis, Fibrosis, Liver, Ultrasound Elastography, Proton Magnetic Resonance Spectroscopy
Interventions: Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule., Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Coronary Stenosis
Interventions: Comparing Accuseal Vs. Bovine Pericardial in CEA; Procedure
Lead sponsor: CAMC Health System; Other
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Charleston, West Virginia

Conditions: Spine Condition, Low Back Pain
Interventions: Not listed
Lead sponsor: Keiser University College of Chiropractic Medicine; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: West Palm Beach, Florida

Conditions: Renal Failure, Renal Artery Stenosis
Interventions: 62Cu-ethylglyoxal bis(thiosemicarbazone), 15O-water, Positron Emission Tomography; Drug · Procedure
Lead sponsor: Jeffrey L. Lacy; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Peripheral Vascular Disease, Peripheral Artery Disease, Carotid Stenosis, Aortic Aneurysm, Abdominal, Aortic Aneurysm, Thoracic, Amputation, Wound, Embolism and Thrombosis, Aortic Aneurysm
Interventions: Not listed
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: New York, New York

Conditions: Esophageal Cancer
Interventions: Endoscopic Ultrasound; Procedure
Lead sponsor: AdventHealth; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Chronic Pancreatitis
Interventions: Pancreatic fully-covered self-expanding metal stent (FCSEMS); Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 6
States / cities: Aurora, Colorado • Indianapolis, Indiana • Pittsburgh, Pennsylvania + 3 more

Conditions: Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, DIPG, High-grade Astrocytoma NOS, CNS Primary Tumor, NOS (Malignant Glioma)
Interventions: INCB7839; Drug
Lead sponsor: Pediatric Brain Tumor Consortium; Network
Eligibility: 3 Years to 21 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 11
States / cities: Los Angeles, California • Palo Alto, California • Aurora, Colorado + 8 more

Conditions: Critical Aortic Stenosis
Interventions: Edwards SAPIEN Transcatheter Heart Valve, Surgical Valve Replacement, medical management and/or balloon aortic valvuloplasty; Device · Other
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: Not listed
Enrollment: 1,057 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2017
U.S. locations: 22
States / cities: La Jolla, California • Los Angeles, California • Stanford, California + 17 more

Conditions: Radiculopathy, Spinal Stenosis, Intervertebral Disc Displacement
Interventions: Transforaminal Epidural Steroid Injection; Procedure
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 21 Years and older
Timeline: Started 2014
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Carotid Artery Stenosis
Interventions: Carotid Stent with Distal Protection Device; Device
Lead sponsor: Providence Health & Services; Other
Eligibility: 18 Years to 90 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Lumbar Spinal Stenosis
Interventions: X-STOP PEEK; Device
Lead sponsor: Medtronic Spine LLC; Industry
Eligibility: 50 Years and older
Enrollment: 176 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2015
U.S. locations: 23
States / cities: Birmingham, Alabama • Tucson, Arizona • Campbell, California + 19 more

Conditions: Aortic Stenosis
Interventions: TAVR; Device
Lead sponsor: Medstar Health Research Institute; Other
Eligibility: 50 Years and older
Enrollment: 200 participants
Timeline: 2018 – 2024
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Symptomatic Aortic Stenosis
Interventions: Embolic Protection Device, Transcatheter aortic valve implantation (TAVI); Device · Procedure
Lead sponsor: Keystone Heart; Industry
Eligibility: 18 Years and older
Enrollment: 478 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 23
States / cities: Los Angeles, California • San Diego, California • New Haven, Connecticut + 18 more

Conditions: Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Spondylolisthesis
Interventions: Kore Fiber, Autologous bone graft; Biological · Other
Lead sponsor: Kolosis Bio, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Coronary Artery Disease, Myocardial Infarction, Myocardial Ischemia, Coronary Artery Occlusion, Coronary Artery Stenosis Stent, Bypass Graft Occlusion, Valve Heart Disease
Interventions: Corrie Hybrid Cardiac Rehabilitation Program; Combination Product
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 259 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Ventricular Outflow Obstruction, Thrombosis
Interventions: Acetylsalicylic acid, Clopidogrel, Rivaroxaban; Drug
Lead sponsor: ECRI bv; Industry
Eligibility: 18 Years and older
Enrollment: 231 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 4
States / cities: Los Angeles, California • New York, New York • Philadelphia, Pennsylvania + 1 more

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Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation

Optical Frequency Domain Imaging (OFDI) for Biliary Stricture Imaging

Revascularization With Open Bypass Versus Angioplasty and STenting of the Lower Extremity Trial (ROBUST)

Dynamic Stabilization for Lumbar Spinal Stenosis With Stabilimax NZ® Dynamic Spine Stabilization System

The Genetics of Cardiomyopathy and Heart Failure

Serp-1 for the Treatment of Acute Coronary Syndrome

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

Trial Comparison of Accuseal and Bovine Pericardial Patch During Endarterectomy

Influence of Flexion Distraction Manipulation on Measures of Performance and Postural Control

Renal Blood Flow Measurement With Positron Emission Tomography (PET)

Platelet Activity in Vascular Surgery for Thrombosis and Bleeding

Relationship Between Endoscopic Ultrasound Staging and Degree of Stricture in Esophageal Cancer

WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial

Steroid Injections Given at the "Level of MRI Pathology" Versus at the "Level of Clinical Symptoms" to See if One is More Effective Than the Other.

Carotid Artery Stenting With Protection Registry

Condition of Approval Study

CoreValve Evolut Pro Prospective Registry

The REFLECT Trial: Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation

Kore Fiber PLF Study

Impact of a Corrie Cardiac Rehabilitation Program

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)