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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Contact Lens Solution Clear all
Completed Not applicable Interventional Results available

Investigational Multi-purpose Contact Lens Care Solution.

NCT01055613
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Vistakon Investigational Multi-Purpose Solution I, ReNu MultiPlus Multi-Purpose Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
15
States / cities
Fresno, California • Pismo Beach, California • Louisville, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional

Comparison of 3 Novel Contact Lens Solutions on the Basal Lamina

NCT00691457
View directory record Official record
Conditions
Contact Lens Solution
Interventions
Opti-Free contact lens solution, ReNu Multiplus contact lens solution, Clear Care contact lens solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Virginia Beach, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2012 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Contact Lens Saline Solutions With Scleral GP Contact Lens Wearers Experiencing Fogging

NCT03525704
View directory record Official record
Conditions
Contact Lens Complication, Debris in Post Lens Tear Reservoir
Interventions
Saline Solution Enriched, Saline Rinse Solution
Device
Lead sponsor
Contamac Ltd
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
West Linn, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

One-month Clinical Evaluation of Oté Sensation Multi-Purpose Solution Care System

NCT03278223
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
Test solution, Control solution
Device
Lead sponsor
OTE North America
Industry
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Sarasota, Florida • Pittsburg, Kansas • Vestal, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye

NCT03417505
View directory record Official record
Conditions
Dry Eye, Dry Eye Syndromes
Interventions
Scleral lenses treated with Tangible Hydra-PEG, Untreated scleral lenses
Device
Lead sponsor
Tangible Science
Industry
Eligibility
18 Years to 70 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Sacramento, California • Fort Lauderdale, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Multi-Purpose Solutions on Ex-Vivo Wetting Angles

NCT00383201
View directory record Official record
Conditions
Contact Lens Care
Interventions
OptiFree Multi-Purpose Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 15, 2012 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

NCT04789382
View directory record Official record
Conditions
Refractive Errors
Interventions
LID018869+RepleniSH, LID018869+Biotrue, Biofinity+RepleniSH, PV+Biotrue
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Tangible Boost Replenishing System

NCT03073148
View directory record Official record
Conditions
Contact Lens Solution
Interventions
Tangible Boost, Placebo saline
Device · Other
Lead sponsor
Tangible Science
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Effect of FID 114675A on Lens Wettability

NCT01342107
View directory record Official record
Conditions
Contact Lens Wettability
Interventions
FID 114675A multi-purpose disinfecting solution (MPDS), Soft contact lens, Blister pack solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical and Laboratory Evaluation of 3 Contact Lenses With 4 Contact Lens Solutions

NCT01791517
View directory record Official record
Conditions
Contact Lens Solutions
Interventions
Solution 1 (Test), Solution 2 (Test), Solution 3 (Test), Solution 4 (Control)
Other
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of 3 Contact Lens Materials With 3 Solution Types

NCT03466060
View directory record Official record
Conditions
Visual Acuity, Slit Lamp Biomicroscopy (Corneal Staining Assessment)
Interventions
Opti-Free : RevitaLens / Clear Care : RevitaLens, Opti-Free : RevitaLens / RevitaLens : Clear Care, Clear Care : RevitaLens/ Opti-Free : RevitaLens, Clear Care : RevitaLens / RevitaLens : Opti-Free, RevitaLens : Clear Care/ Opti-Free : RevitaLens, RevitaLens : Clear Care / RevitaLens : Opti-Free, RevitaLens : Opti-Free / Clear Care : RevitaLens, RevitaLens : Opit-Free / RevitaLens : Clear Care
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
5
States / cities
Anaheim, California • Berkeley, California • Jacksonville, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness

NCT03686878
View directory record Official record
Conditions
Contact Lens, Contact Lens Discomfort, Contact Lens Dryness
Interventions
Lifitegrast
Drug
Lead sponsor
EV Clinical Trials
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear

NCT01015768
View directory record Official record
Conditions
Contact Lens-induced Corneal Fluorescein Staining
Interventions
ReNu Multiplus multipurpose disinfecting solution, Control
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Daily Disposable Lenses With Multi-Purpose Solution (MPS)

NCT00733291
View directory record Official record
Conditions
Myopia
Interventions
Nelfilcon A contact lens, Etafilcon A contact lens, FID 107027 solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 27, 2011 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional

Clinical Evaluation of the Causes of Contact Lens Related Dry Eye

NCT00995189
View directory record Official record
Conditions
Contact Lens Related Dry Eye
Interventions
Opti-Free RepleniSH, ReNu MultiPlus, Contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2016 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Physiological Consequence of Silicone-hydrogel Care-solution Bio-incompatibility

NCT00829751
View directory record Official record
Conditions
Contact Lens Solution Toxicity
Interventions
PureVision lenses soaked in ReNu Multiplus, PureVision lenses soaked in OptiFree RePlenish
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Lens Wearing Experience and Biocompatibility of a Multi-Purpose Disinfecting Solution (MPDS)

NCT01476722
View directory record Official record
Conditions
Healthy
Interventions
OPTI-FREE PureMoist multipurpose disinfecting solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2012 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of A New Contact Lens Cleaning and Disinfecting Solution

NCT01318577
View directory record Official record
Conditions
Vision Disorders
Interventions
Investigational Cleaning & Disinfecting Solution, Clear Care Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
444 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Corneal Barrier Function With Multi-Purpose Solutions

NCT00407238
View directory record Official record
Conditions
Contact Lens Care
Interventions
Multi-purpose solutions (polyquaternium-1 and PHMB)
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Oct 22, 2007 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Phase 4 Interventional

A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE)

NCT01105624
View directory record Official record
Conditions
Contact Lens Dry Eye
Interventions
azithromycin ophthalmic solution, 1%, Visine® for Contacts®
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 25, 2011 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of an Investigational Multi-Purpose Disinfecting Solution for Care of Soft Contact Lenses

NCT00382681
View directory record Official record
Conditions
Contact Lens Care
Interventions
FID 107027 Multi-Purpose Disinfecting Solution, ReNu MultiPlus Multi-Purpose Solution No Rub Formula
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004
U.S. locations
1
States / cities
Elkin, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of a New Contact Lens Cleaning and Disinfecting Solution

NCT02701556
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Complete MPS, NNR06
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Pittsburg, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Sep 15, 2026, 4:52 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells

NCT01104961
View directory record Official record
Conditions
Corneal Ulcer
Interventions
Contact lens packaging solution, Balanced salt solution (BSS)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 38 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Sep 15, 2026, 4:52 PM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of a Bausch & Lomb Multipurpose Solution When Compared to Ciba Vision Aquify Multipurpose Solution

NCT00636363
View directory record Official record
Conditions
Contact Lens Solutions
Interventions
Bausch & Lomb Multipurpose Solution - Rub Care, Bausch & Lomb Multipurpose Solution - No Rub Care, Ciba Vision Aquify Multipurpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
541 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Le Roy, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Sep 15, 2026, 4:52 PM EDT