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Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Contact Lens Solutions Clear all
Completed Not applicable Interventional Results available

Biotrue ONEday Contact Lenses With EPG03 Packaging Solution Compared to Biotrue ONEday Contact Lenses

NCT05129488
View directory record Official record
Conditions
Contact Lens Wearer
Interventions
All participants received Biotrue ONEday lenses with and without an alternate packaging solution (EPG03)
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional

Comparison of OPTI-FREE RepleniSH and ReNu Multi-Plus Lens Care Regimens on Corneal Epithelium

NCT00724269
View directory record Official record
Conditions
Contact Lens Wear
Interventions
OPTI-FREE RepleniSH, ReNu MultiPlus MPS
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2012 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of 3 Contact Lens Materials With 3 Solution Types

NCT03466060
View directory record Official record
Conditions
Visual Acuity, Slit Lamp Biomicroscopy (Corneal Staining Assessment)
Interventions
Opti-Free : RevitaLens / Clear Care : RevitaLens, Opti-Free : RevitaLens / RevitaLens : Clear Care, Clear Care : RevitaLens/ Opti-Free : RevitaLens, Clear Care : RevitaLens / RevitaLens : Opti-Free, RevitaLens : Clear Care/ Opti-Free : RevitaLens, RevitaLens : Clear Care / RevitaLens : Opti-Free, RevitaLens : Opti-Free / Clear Care : RevitaLens, RevitaLens : Opit-Free / RevitaLens : Clear Care
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
5
States / cities
Anaheim, California • Berkeley, California • Jacksonville, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear

NCT01015768
View directory record Official record
Conditions
Contact Lens-induced Corneal Fluorescein Staining
Interventions
ReNu Multiplus multipurpose disinfecting solution, Control
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Two Phase Clinical Study of the Impact of Contact Lenses and Solutions on Corneal Structure

NCT00804999
View directory record Official record
Conditions
Normal Contact Lens Wear
Interventions
Clear Care, ReNu, OPTI-FREE
Drug
Lead sponsor
Christine Sindt
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

NCT04789382
View directory record Official record
Conditions
Refractive Errors
Interventions
LID018869+RepleniSH, LID018869+Biotrue, Biofinity+RepleniSH, PV+Biotrue
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Maitland, Florida
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Jul 22, 2026, 2:04 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Corneal Staining With Various Contact Lens/Solution Combinations

NCT00381446
View directory record Official record
Conditions
Corneal Epithelial Disruption, Corneal Staining
Interventions
Marketed contact lens care products
Device
Lead sponsor
Andrasko, Gary, OD, LLC
Individual
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 26, 2007 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Tangible Boost Replenishing System

NCT03073148
View directory record Official record
Conditions
Contact Lens Solution
Interventions
Tangible Boost, Placebo saline
Device · Other
Lead sponsor
Tangible Science
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

2-Hour Dispensing Evaluation of Samfilcon A Lenses With EPG01 Packaging Solution Compared to Commercially Available B+L Ultra Lenses

NCT05126953
View directory record Official record
Conditions
Contact Lens Wearer
Interventions
samfilcon A Lenses with EPG01 Packaging Solution, Commercially Available B+L Ultra Lenses
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Alcon Multi-Purpose Disinfecting Solution Versus Renu Fresh Multi-Purpose Solution in Symptomatic Contact Lens Wearers

NCT01187355
View directory record Official record
Conditions
Symptomatic Contact Lens Wearers
Interventions
FID 114675A Multi-Purpose Disinfecting Solution (MPDS), renu fresh Multi-Purpose Solution (MPS), Contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
591 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2012 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional

A Safety and Effectiveness Study of a New Multi-Purpose Contact Lens Care Solution

NCT03537248
View directory record Official record
Conditions
Contact Lens Wear
Interventions
ASP-57, ReNu® Multiplus
Device
Lead sponsor
Asepticys LLC
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
14
States / cities
Irvine, California • San Diego, California • Longwood, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional

Comparison of 3 Novel Contact Lens Solutions on the Basal Lamina

NCT00691457
View directory record Official record
Conditions
Contact Lens Solution
Interventions
Opti-Free contact lens solution, ReNu Multiplus contact lens solution, Clear Care contact lens solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Virginia Beach, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2012 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of an Investigational Multi-Purpose Disinfecting Solution for Care of Soft Contact Lenses

NCT00382681
View directory record Official record
Conditions
Contact Lens Care
Interventions
FID 107027 Multi-Purpose Disinfecting Solution, ReNu MultiPlus Multi-Purpose Solution No Rub Formula
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004
U.S. locations
1
States / cities
Elkin, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of a New Contact Lens Cleaning and Disinfecting Solution

NCT02701556
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Complete MPS, NNR06
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Pittsburg, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Jul 22, 2026, 2:04 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells

NCT01104961
View directory record Official record
Conditions
Corneal Ulcer
Interventions
Contact lens packaging solution, Balanced salt solution (BSS)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 38 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2018 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Objective Testing of Tear Film Stability

NCT00789529
View directory record Official record
Conditions
Contact Lens Solutions
Interventions
Opti-Free® RepleniSH® MPDS, ReNu MultiPlus®
Device
Lead sponsor
Manhattan Vision Associates
Other
Eligibility
18 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2013 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Investigational Multi-purpose Contact Lens Care Solution.

NCT01055613
View directory record Official record
Conditions
Contact Lens Wear
Interventions
Vistakon Investigational Multi-Purpose Solution I, ReNu MultiPlus Multi-Purpose Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
15
States / cities
Fresno, California • Pismo Beach, California • Louisville, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Physiological Consequence of Silicone-hydrogel Care-solution Bio-incompatibility

NCT00829751
View directory record Official record
Conditions
Contact Lens Solution Toxicity
Interventions
PureVision lenses soaked in ReNu Multiplus, PureVision lenses soaked in OptiFree RePlenish
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a Multi-Purpose Solution

NCT00710879
View directory record Official record
Conditions
Contact Lens Solutions
Interventions
Bausch & Lomb Multi-Purpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2011 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Comparative In-Vivo Wetting Characteristics of Silicone Hydrogel Materials With Selected Lens Care Systems

NCT01699750
View directory record Official record
Conditions
Myopia, Astigmatism, Refractive Error
Interventions
Lotrafilcon B contact lenses, Senofilcon A contact lenses, OPTI-FREE® PUREMOIST® MPDS, BIOTRUE®, Balafilcon A contact lenses, ReNu® Multiplus®
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 7, 2014 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Comparison of Two Multi-Purpose Solution and Lens Material Combinations on Corneal Barrier Function

NCT00560898
View directory record Official record
Conditions
Contact Lens Disinfecting Solutions
Interventions
ProClear Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in ReNu Multiplus Multipurpose Solution, Acuvue Advance Lens Material soaked in Optifree RepleniSH Multipurpose Solution, ProClear Lens Material soaked in Optifree RepleniSH Multipurpose Solution
Drug
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated May 19, 2008 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wettability of Contact Lenses With a Multi-Purpose Solution

NCT00713076
View directory record Official record
Conditions
Vision
Interventions
Polyquaternium-preserved Multi-purpose Lens Cleaning Solution 109182
Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2014 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of a Bausch & Lomb Multipurpose Solution When Compared to Ciba Vision Aquify Multipurpose Solution

NCT00636363
View directory record Official record
Conditions
Contact Lens Solutions
Interventions
Bausch & Lomb Multipurpose Solution - Rub Care, Bausch & Lomb Multipurpose Solution - No Rub Care, Ciba Vision Aquify Multipurpose Solution
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
541 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Le Roy, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Phase 4 Interventional

Comfort and Cleaning Evaluation of Multipurpose Solutions in Contact Lens Patients

NCT00519948
View directory record Official record
Conditions
Patient Comfort, Lens Cleanliness
Interventions
new MPS, opti-free express no rub MPS
Drug
Lead sponsor
Innovative Medical
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Timeline
Ends 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2008 · Synced Jul 22, 2026, 2:04 PM EDT