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Showing 1–24 of 212 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Couples Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Drinking in Young Adult Duos (DYAD) Study

NCT06822257
View directory record Official record
Conditions
Alcohol Consumption, Alcohol Drinking, Alcohol Intoxication
Interventions
Alcohol beverage, Non-alcohol beverage
Drug · Other
Lead sponsor
Carnegie Mellon University
Other
Eligibility
21 Years to 30 Years
Enrollment
504 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 21, 2026, 4:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Promoting Co-Parenting and Reducing Hazardous Drinking in New Families

NCT04441307
View directory record Official record
Conditions
Parenting, Parent-Child Relations, Drinking, Alcohol, Adjustment
Interventions
Healthy Foundations, Family Foundations
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Henrietta, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Efficacy of a Spousal Support Enhanced Weight Loss Program on Weight Loss Among African American Men

NCT02458053
View directory record Official record
Conditions
Overweight, Weight Loss, Obese
Interventions
Attends with partner, Couples Skill Training, Face to face group sessions, Self Monitor, Notebook, Feedback
Behavioral · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 13, 2017 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional

Testing A Couple-based Program for Alcohol Risk Reduction in the National Guard

NCT03589508
View directory record Official record
Conditions
Alcohol; Harmful Use
Interventions
In-person sessions: ABCP_P, Video conference sessions: ABCP_T
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 22, 2019 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prison Connect-STI/HIV Prevention Intervention for Couples Affected by Incarceration

NCT03025191
View directory record Official record
Conditions
Incarceration
Interventions
Speaker/Listener technique, Social Support, Problem-Solving, Goal Setting
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Preventing Sexual Transmission of HIV With Anti-HIV Drugs

NCT00074581
View directory record Official record
Conditions
HIV Infections
Interventions
Atazanavir, Didanosine, Efavirenz, Emtricitabine/Tenofovir disoproxil fumarate, Lamivudine, Lopinavir/Ritonavir, Nevirapine, Stavudine, Tenofovir disoproxil fumarate, Zidovudine/Lamivudine
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
3,526 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional

Duo Partnership Adherence Commitment Therapy

NCT02925949
View directory record Official record
Conditions
HIV/AIDS
Interventions
DuoPACT, LifeSteps
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Online HIV Prevention for Young Male Couples

NCT03284541
View directory record Official record
Conditions
Hiv, Chlamydia, Gonorrhea
Interventions
2GETHER, Existing Public Health Practice
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Male only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Jul 21, 2026, 4:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multidimensional Sleep Health Intervention for Couples

NCT07603245
View directory record Official record
Conditions
Blood Pressure, Sleep, Cardiovascular Health
Interventions
Multidimensional Sleep Health Promotion Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
30 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Sexual Safety: Couples' Communication and HIV Testing Among YMSM

NCT04289116
View directory record Official record
Conditions
HIV/AIDS, HIV Infections
Interventions
We Test, IHTC
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
15 Years to 24 Years · Male only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Detroit, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Jul 21, 2026, 4:45 PM EDT
Not listed Phase 1 Interventional

A Randomized Trial to Prevent HIV Among Gay Couples

NCT03189394
View directory record Official record
Conditions
HIV Infections
Interventions
PRIDE, ePRIDE, Men's Health
Behavioral
Lead sponsor
San Francisco State University
Other
Eligibility
18 Years and older · Male only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional

Coping Together: Couple-based Interventions for Cancer

NCT04590885
View directory record Official record
Conditions
Advanced Cancer
Interventions
Couple Communication Skills Training, Healthy Lifestyle Information
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)

NCT04845542
View directory record Official record
Conditions
Stroke, Depression, Anxiety, Coping Skills, Couples
Interventions
ReStoreD
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing the Effects of Active Surveillance Stress, Uncertainty and Rumination Thru Engagement in Mindfulness Education

NCT02871752
View directory record Official record
Conditions
Prostate Cancer
Interventions
Health promotion
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
4
States / cities
Chicago, Illinois • Evanston, Illinois • Ann Arbor, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2023 · Synced Jul 21, 2026, 4:45 PM EDT
Active, not recruiting Not applicable Interventional

Couples' QOL in Metastatic Breast Cancer

NCT05636943
View directory record Official record
Conditions
Metastatic Breast Cancer
Interventions
Adapted Intimacy Enhancement, Intimacy Facts and Resources
Behavioral
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 2, 2025 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional

Use of Mobile Apps for Those With PTSD and Their Partners

NCT02780635
View directory record Official record
Conditions
Ptsd
Interventions
Mobile App + Mailed Materials for managing stress associated with PTSD, Mobile App for managing stress associated with PTSD
Behavioral
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years to 90 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jul 21, 2026, 4:45 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Project Harmony 2.0: Relationship Education for Couples

NCT05587335
View directory record Official record
Conditions
Marital Relationship
Interventions
PREP, OurRelationship
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
1,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jul 21, 2026, 4:45 PM EDT
Recruiting Not applicable Interventional

Resilient Together for Dementia (RT-D)

NCT06619327
View directory record Official record
Conditions
Dementia
Interventions
Resilient Together for Dementia, MEUC
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Safety Evaluation of Personal Lubricant Product When Used by Couples in Home-use Conditions

NCT00779025
View directory record Official record
Conditions
Coitus
Interventions
PD-F-5254, 10855-096
Device
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 6, 2011 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comprehensive HIV Prevention Package for MSM in Southern Africa: Pilot Study (Sibanye Health Project)

NCT02043015
View directory record Official record
Conditions
HIV
Interventions
Condom choices, Condom-compatible lubricant choices, Couples HIV counseling and testing (CVCT), Pre-exposure prophylaxis with FTC/TDF, Staff and provider MSM and LGBT sensitization training, HIV Testing and Risk-reduction counseling, Linkage to care
Behavioral · Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Atlanta, Georgia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Jul 21, 2026, 4:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Couple-Based Meditation for Metastatic Lung Cancer Patients and Their Partners

NCT02596490
View directory record Official record
Conditions
Lung Cancer
Interventions
Questionnaires, Meditation and Discussion Sessions, Cancer-Related Discussion Program
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Empowering Families Project

NCT05359185
View directory record Official record
Conditions
Couples, Relationship, Marital, Relational Problems
Interventions
Family Wellness, Career Coaching, Financial Planning
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
666 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 21, 2026, 4:45 PM EDT
Recruiting Not applicable Interventional

Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples

NCT06047691
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Abbreviated, Intensive, Multi-Couple Group Cognitive-Behavioral Conjoint Therapy for PTSD, Prevention and Relationship Education Program
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2025 · Synced Jul 21, 2026, 4:45 PM EDT
Completed Not applicable Interventional Results available

Wearable Technology and Alcohol-Facilitated Intimate Partner Violence

NCT05374798
View directory record Official record
Conditions
Alcohol Abuse, IPV, Couples
Interventions
Heart Rate Variability-Biofeedback (HRV-B) via Smartwatch Device Intervention
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 70 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Jul 21, 2026, 4:45 PM EDT