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ClinicalTrials.gov public records Last synced Oct 21, 2026, 3:32 AM EDT

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Showing 1–24 of 54 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Couples Therapy Clear all
Active, not recruiting Not applicable Interventional

Clinical Trial of the Online OurRelationship Program for Veteran Couples

NCT05136651
View directory record Official record
Conditions
Relationship Distress
Interventions
OurRelationship
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 21, 2026, 3:32 AM EDT
Recruiting Not applicable Interventional

A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

NCT06990191
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Partnered Prolonged Exposure (PPE), Prolonged Exposure (PE)
Behavioral
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Phoenix, Arizona • San Diego, California • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners

NCT03112668
View directory record Official record
Conditions
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer, Stage III Cervical Cancer, Stage III Colorectal Cancer, Stage III Lung Cancer, Stage III Prostate Cancer, Stage III Skin Melanoma, Stage III Uterine Corpus Cancer, Stage IIIA Breast Cancer, Stage IIIA Cervical Cancer, Stage IIIA Colorectal Cancer, Stage IIIA Lung Carcinoma, Stage IIIA Skin Melanoma, Stage IIIA Uterine Corpus Cancer, Stage IIIB Breast Cancer, Stage IIIB Cervical Cancer, Stage IIIB Colorectal Cancer, Stage IIIB Lung Carcinoma, Stage IIIB Skin Melanoma, Stage IIIB Uterine Corpus Cancer, Stage IIIC Breast Cancer, Stage IIIC Colorectal Cancer, Stage IIIC Skin Melanoma, Stage IIIC Uterine Corpus Cancer, Stage IV Breast Cancer, Stage IV Cervical Cancer, Stage IV Colorectal Cancer, Stage IV Lung Cancer, Stage IV Prostate Cancer, Stage IV Skin Melanoma, Stage IV Uterine Corpus Cancer, Stage IVA Cervical Cancer, Stage IVA Colorectal Cancer, Stage IVA Uterine Corpus Cancer, Stage IVB Cervical Cancer, Stage IVB Colorectal Cancer, Stage IVB Uterine Corpus Cancer
Interventions
Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration, Survey Administration
Behavioral · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Phase 2 Interventional

Couples Therapy for Alcoholic Patients

NCT01659957
View directory record Official record
Conditions
Alcoholism
Interventions
Group Couples Counseling, One-on-One Couples Counseling
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
18 Years to 65 Years
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional

Duo Partnership Adherence Commitment Therapy

NCT02925949
View directory record Official record
Conditions
HIV/AIDS
Interventions
DuoPACT, LifeSteps
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercising Together During Radiation Treatment

NCT03418025
View directory record Official record
Conditions
Domestic Partnership, Prostate Carcinoma, Spouse
Interventions
Exercise Intervention, Questionnaire Administration, Survey Administration
Behavioral · Other
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional

A Couples Approach to Enhance Breast Cancer Survivorship

NCT00665899
View directory record Official record
Conditions
Early-Stage Breast Cancer
Interventions
Cancer-Focused Relationship Enhancement, Couple's Cancer Education
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Not listed
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Phase 2 Interventional Results available

Oxytocin to Enhance Alcohol Behavioral Couple Therapy (ABCT)

NCT03846505
View directory record Official record
Conditions
Alcohol Use Disorder, Couples
Interventions
Oxytocin, Placebo
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Oct 21, 2026, 3:32 AM EDT
Withdrawn Not applicable Interventional

UCLA Couples Counseling for Combat Veterans

NCT01627548
View directory record Official record
Conditions
PTSD, Recent Era Combat Veteran, Couples Communication
Interventions
Structured Approach Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Phase 1 Interventional Results available

Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder

NCT00946322
View directory record Official record
Conditions
Alcohol-related Disorders, Post-traumatic Stress Disorder
Interventions
Couple-Based Treatment for Alcohol Use Disorders and PTSD
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness Based Couples Therapy

NCT02349217
View directory record Official record
Conditions
Breast Cancer
Interventions
Mindfulness-Based Relationship Enhancement (MBRE), Self-Help Materials, Pain Assessment, Questionnaires, Neurocognitive Tests, Cortisol Tests, Interviews
Behavioral · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Oct 21, 2026, 3:32 AM EDT
Active, not recruiting Not applicable Interventional

Relationship Checkups to Reduce Veteran Suicide Risk

NCT05525676
View directory record Official record
Conditions
Relationship Distress, Mental Health
Interventions
Brief Relationship Checkup (BRC), Co-Located Collaborative Care (CCC)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 21, 2026, 3:32 AM EDT
Not yet recruiting Not applicable Interventional

Adapting the Manage Emotions to Reduce Aggression Therapy to Reduce Intimate Partner Violence and Promote Psychosocial Recovery in Veteran Couples (MERA-C)

NCT07749755
View directory record Official record
Conditions
Intimate Partner Violence
Interventions
Manage Emotions to Reduce Aggression- Couples, Manage Emotions to Reduce Aggression
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Results available

A Pilot of the Brief Relationship Checkup

NCT06011161
View directory record Official record
Conditions
Relationship Distress
Interventions
Brief Relationship Checkup (BRC)
Behavioral
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional

Feasibility Trial of an Online Course (eMB) to Reduce Anxiety and Depression for Pregnant Women and Their Partners

NCT05867680
View directory record Official record
Conditions
Anxiety Disorders Generalized, Depression
Interventions
Online Mothers and Babies Course (eMB)
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

"Up-Armoring" At-Risk Military Couples: A Stepped Approach to Early Intervention and Strengthening of Military Families

NCT06948877
View directory record Official record
Conditions
Couples Therapy, Military Family
Interventions
ARMOR Online
Behavioral
Lead sponsor
Wright State University
Other
Eligibility
18 Years and older
Enrollment
581 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Biloxi, Mississippi
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 21, 2026, 3:32 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Hatha Yoga in Lung Cancer Couples

NCT01952860
View directory record Official record
Conditions
Lung Cancer
Interventions
Hatha Yoga, Questionnaires
Other · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 3, 2020 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Results available

Uniting Couples in the Treatment of Binge-Eating Disorder

NCT03784820
View directory record Official record
Conditions
Binge-Eating Disorder
Interventions
UNITE, CBT-E
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Results available

Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI

NCT02057081
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Posttraumatic Stress Disorders, Depression
Interventions
Multifamily Group for mTBI for Couples, Group Health Education (GHE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Baltimore, Maryland • New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Phase 2 Interventional Results available

Brief Cognitive Behavioral Conjoint Therapy for PTSD With Adjunctive Intranasal Oxytocin

NCT05207436
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Relational Problems
Interventions
Oxytocin nasal spray, Brief Cognitive-Behavioral Conjoint Therapy
Drug · Behavioral
Lead sponsor
San Diego Veterans Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional

Uniting Couples In the Treatment of Eating Disorders (UNITE)

NCT02419326
View directory record Official record
Conditions
Binge-eating Disorder, Eating Disorder
Interventions
Psychotherapy treatment
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Results available

Effects of Mindfulness-Based Cognitive-Behavioral Conjoint Therapy on PTSD and Relationship Function

NCT01035788
View directory record Official record
Conditions
PTSD
Interventions
Mindfulness Based Cognitive Behavioral Conjoint Therapy, CBCT for PTSD - Communication Skills
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 1, 2018 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Behavioral Couples Therapy for Female Drug-Abusing Patients

NCT01189305
View directory record Official record
Conditions
Drug Abuse
Interventions
Behavioral Couples Therapy, Individual Drug Counseling
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Oct 21, 2026, 3:32 AM EDT
Completed Not applicable Interventional Results available

Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19

NCT05419128
View directory record Official record
Conditions
Alcohol Use Disorder, Family Members, Behavior, Addictive
Interventions
PartnerCHESS, ACHESS
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 21, 2026, 3:32 AM EDT