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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Craniocerebral Injuries Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Screening Brain MRI in High School Football: Does the Guardian Cap Reduce the Risk of Traumatic Brain Injury

NCT02757053
View directory record Official record
Conditions
Brain Concussion, Brain Injuries, Diffuse Axonal Injury, Athletic Injuries, Injury, Brain, Traumatic
Interventions
Guardian Cap
Device
Lead sponsor
Mosaic Life Care
Other
Eligibility
12 Years to 20 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Saint Joseph, Missouri
Source: ClinicalTrials.gov public record
Updated May 13, 2018 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Not applicable Interventional

Feasibility of a Purpose in Life Renewal Intervention for Adults With Persistent Symptoms After Concussion

NCT05780658
View directory record Official record
Conditions
Concussion; Syndrome
Interventions
Compass Course
Behavioral
Lead sponsor
Mary Radomski
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Jun 10, 2026, 9:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Deployment Related Mild Traumatic Brain Injury (mTBI)

NCT01847040
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
The Defense and Veterans Brain Injury Center
Federal
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
2
States / cities
Fort Carson, Colorado • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 24, 2019 · Synced Jun 10, 2026, 9:17 AM EDT
Completed No phase listed Observational

Effects of Transport on Patients With Traumatic Brain Injury

NCT01077089
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2013 · Synced Jun 10, 2026, 9:17 AM EDT
Not listed Not applicable Interventional

Evaluate the SENSE Device's Ability to Monitor and Detect Intracranial Hemorrhage

NCT04642443
View directory record Official record
Conditions
Intracranial Hemorrhages, Traumatic Brain Injury
Interventions
SENSE Device
Device
Lead sponsor
Sense Diagnostics, LLC
Industry
Eligibility
22 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Not applicable Interventional

Comparative Utility of Clinical Balance Measures in Traumatic Brain Injury

NCT02696538
View directory record Official record
Conditions
Traumatic Brain Injury, Acquired Brain Injury, Accidental Falls
Interventions
Functional Gait Assessment, mini-Balance Evaluation Systems Test, Berg Balance Scale
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2018 · Synced Jun 10, 2026, 9:17 AM EDT
Completed No phase listed Observational

Non-Interventional F-Two Isoprostane Trial (NIFTI)

NCT00505908
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2020 · Synced Jun 10, 2026, 9:17 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Cortical Plasticity Assessment in Athletes With a History of Concussion

NCT01112761
View directory record Official record
Conditions
Concussion
Interventions
Transcranial direct current stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Phase 2 Interventional Results available

Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury

NCT03095066
View directory record Official record
Conditions
Neurobehavioral Disinhibition
Interventions
Placebo, AVP-786-28, AVP-786-42.63
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
54
States / cities
Tuscaloosa, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 45 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jun 10, 2026, 9:17 AM EDT
Withdrawn Not applicable Interventional

LED Light Therapy to Improve Cognitive & Psychosocial Function in TBI-PTSD Veterans

NCT02356861
View directory record Official record
Conditions
Traumatic Brain Injury (TBI), Post-traumatic Stress Disorder (PTSD)
Interventions
Photomedex Sham Helmet with Red/Near-Infrared Light-Emitting Diodes (LEDs) that are not turned on
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Jun 10, 2026, 9:17 AM EDT
Completed No phase listed Observational

Service Member Fatigue and Lack of Motivation Following Concussion

NCT01496586
View directory record Official record
Conditions
Fatigue, Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Not applicable Interventional

Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI

NCT02922569
View directory record Official record
Conditions
Mild Traumatic Brain Injury
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Mindfulness Training, Traumatic Brain Injury Information Session
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jun 10, 2026, 9:17 AM EDT
Recruiting Phase 3 Interventional

Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

NCT06581003
View directory record Official record
Conditions
Traumatic Brain Injury, Military Operations
Interventions
Oxygen 99.7 %, Oxygen 21 %
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Jun 10, 2026, 9:17 AM EDT
Not listed Not applicable Interventional

REACH Hope Intervention for Dementia and TBI Caregivers

NCT04969796
View directory record Official record
Conditions
Dementia, Mixed, Dementia of Alzheimer Type, TBI (Traumatic Brain Injury)
Interventions
REACH Hope
Other
Lead sponsor
Memphis VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Not applicable Interventional

Effects of Aerobic Exercise on Cognition, Mood and Fatigue Following TBI

NCT00619463
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Exercise
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Jun 10, 2026, 9:17 AM EDT
Enrolling by invitation Not applicable Interventional

Pilot TMS in Mild TBI

NCT06999304
View directory record Official record
Conditions
Persistent Post Concussive Headache, Mild Traumatic Brain Injury
Interventions
Intermittent theta burst stimulation
Device
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Jun 10, 2026, 9:17 AM EDT
Completed No phase listed Observational Results available

Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population

NCT00715949
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion
Interventions
Immediate Post-concussion Assessment and Cognitive Testing
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 19 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Jun 10, 2026, 9:17 AM EDT
Recruiting No phase listed Observational

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

NCT07455136
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Blood sample collection
Procedure
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
13
States / cities
Sacramento, California • San Francisco, California • Carmel, Indiana + 10 more
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Phase 2 Interventional Results available

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

NCT02225106
View directory record Official record
Conditions
Cognition Disorder, Attention Deficit Disorder, Traumatic Brain Injury
Interventions
Methylphenidate
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 14, 2019 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Phase 2 Interventional Results available

Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).

NCT01988584
View directory record Official record
Conditions
Cerebral Palsy
Interventions
umbilical cord blood (hUCB) cells, Saline Infusion (Placebo), bone marrow derived mononuclear cells (BMMNCs)
Biological · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 10 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jun 10, 2026, 9:17 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Longitudinal Assessment of Traumatic Microvascular Injury-2

NCT05725993
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jun 10, 2026, 9:17 AM EDT
Recruiting No phase listed Observational

Evaluation of the SCALED (SCaling AcceptabLE cDs)

NCT05628207
View directory record Official record
Conditions
Traumatic Brain Injury, Venous Thromboembolism
Interventions
Observational, Observational-control
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
15,000 participants
Timeline
2023 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jun 10, 2026, 9:17 AM EDT
Terminated Not applicable Interventional Results available

Lumbar Drain After Endoscopic Surgery of the Skull Base

NCT03163134
View directory record Official record
Conditions
Quality of Life
Interventions
Lumbar Drain
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Jun 10, 2026, 9:17 AM EDT
Completed Not applicable Interventional

The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients

NCT03938584
View directory record Official record
Conditions
Vitamin C Deficiency, Smoking, Surgery, Surgery--Complications, Wound, Wound Complication, Wound Infection, Wound Dehiscence, Wound of Skin, Mandible Fracture, Mandible Open Fracture, Mandible Closed Fracture, Mandibular Fractures, Ascorbic Acid Deficiency, Oxidative Stress, Inflammation
Interventions
Vitamin C, Placebo
Dietary Supplement · Other
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Jun 10, 2026, 9:17 AM EDT