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ClinicalTrials.gov public records Last synced Oct 21, 2026, 4:59 AM EDT

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Showing 25–44 of 44 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Craniofacial Pain Syndrome Clear all
Recruiting Phase 4 Interventional

OnabotulinumtoxinA for Trigeminal Neuralgia

NCT06216886
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
OnabotulinumtoxinA 100 UNT [Botox], Sodium Chloride 0.9% for Injection, Preservative Free
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Phase 4 Interventional Results available

Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia

NCT04158752
View directory record Official record
Conditions
Trigeminal Neuralgia, Glossopharyngeal Neuralgia
Interventions
Galcanezumab
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 21, 2026, 4:59 AM EDT
Terminated Phase 3 Interventional Results available

A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia

NCT01364259
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Amifostine, CyberKnife stereotactic radiosurgery
Drug · Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Not applicable Interventional Results available

Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia

NCT00203229
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
lamotrigine, Placebo
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
15 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 21, 2026, 4:59 AM EDT
Completed No phase listed Observational

The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache

NCT04845451
View directory record Official record
Conditions
Cluster Headache, Craniofacial Pain Syndrome
Interventions
Minimal surgical exploration for a neuroma
Other
Lead sponsor
FARO T. OWIESY, M.D
Other
Eligibility
20 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Corona, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

New Formulation and Food Effect Study of BIIB074

NCT02951221
View directory record Official record
Conditions
Trigeminal Neuralgia (TN), Other Neuropathic Pain
Interventions
BIIB074 Treatment A, BIIB074 Treatment B, BIIB074 Treatment C, BIIB074 Treatment D
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 21, 2026, 4:59 AM EDT
Active, not recruiting Not applicable Interventional

MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia

NCT04579692
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
ExAblate Transcranial treatment
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 21, 2026, 4:59 AM EDT
Recruiting No phase listed Observational

RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT

NCT01885299
View directory record Official record
Conditions
Neoplasms, Arteriovenous Malformation of Central Nervous System, Trigeminal Neuralgia
Interventions
SRS/SBRT
Radiation
Lead sponsor
The Radiosurgery Society
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2030
U.S. locations
13
States / cities
Colorado Springs, Colorado • Miami, Florida • Brunswick, Georgia + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 21, 2026, 4:59 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain

NCT01920087
View directory record Official record
Conditions
Atypical Facial Pain, Persistent Idiopathic Facial Pain, Atypical Trigeminal Neuralgia, Neuropathic Orofacial Pain, Neuropathic Facial Pain
Interventions
ATNC05, Placebo
Drug
Lead sponsor
Allodynic Therapeutics, Inc
Industry
Eligibility
18 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
North Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 13, 2014 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Not applicable Interventional

A Nasal Applicator for the Treatment of Trigeminal Neuralgia

NCT01761604
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Nasal ganglion block for TN
Device
Lead sponsor
Chicago Anesthesia Pain Specialists
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Not applicable Interventional

Feasibility of Olive Oil for Reducing Facial Pain of Trigeminal Neuralgia

NCT05032573
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Olive oil and Dietary Guideline recommendations, Dietary Guideline recommendations
Dietary Supplement · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Oct 21, 2026, 4:59 AM EDT
Not listed Not applicable Interventional

An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia

NCT02801630
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
PainShield SAW Patch Device
Device
Lead sponsor
Rosenblum, Jonathan I., DPM
Individual
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Elmsford, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Oct 21, 2026, 4:59 AM EDT
Not listed Phase 3 Interventional

SPG Block for Acute Pediatric Migraine

NCT03984045
View directory record Official record
Conditions
Migraine in Children, Sphenopalatine Neuralgia, Migraine in Adolescence
Interventions
Lidocaine topical, Prochlorperazine Injection
Drug
Lead sponsor
Newark Beth Israel Medical Center
Other
Eligibility
10 Years to 20 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 17, 2021 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy

NCT03865940
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Lidocaine, Guanfacine
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 21, 2026, 4:59 AM EDT
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception

NCT00349050
View directory record Official record
Conditions
Pain, Trigeminal Neuralgia, Neuropathic Pain
Interventions
laboratory pain assessment, transcranial magnetic stimulation
Device · Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2012 · Synced Oct 21, 2026, 4:59 AM EDT
Completed No phase listed Observational

A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia

NCT01364285
View directory record Official record
Conditions
Trigeminal Neuralgia
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neurophysiologic Signatures of Trigeminal Neuralgia Pain

NCT03778177
View directory record Official record
Conditions
Trigeminal Neuralgia (TN)
Interventions
transcranial electrical brain stimulation
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Oct 21, 2026, 4:59 AM EDT
Completed Phase 4 Interventional Results available

(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

NCT03381261
View directory record Official record
Conditions
Migraine
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 21, 2026, 4:59 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Risk of Nerve Damage After Administration of Local Anesthesia

NCT06564987
View directory record Official record
Conditions
Inferior Alveolar Nerve Injuries
Interventions
4% Articaine with 1:200,000 epinephrine, 2% lidocaine with 1:100,000 epinephrine
Drug
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Akron, Ohio • Ashtabula, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Oct 21, 2026, 4:59 AM EDT