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Showing 1–24 of 51 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Craniotomy Clear all
Recruiting Not applicable Interventional

rTMS for Postoperative Brain Tumor Patients

NCT07530536
View directory record Official record
Conditions
Brain Tumors, Transcranial Magnetic Stimulation, Motor Deficit, Quality of Life
Interventions
Transcranial magnetic stimulation (TMS)
Device
Lead sponsor
Brian J.Gill
Other
Eligibility
22 Years to 65 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Completed No phase listed Observational

Quality of Recovery Awake Versus Asleep Craniotomy

NCT02228993
View directory record Official record
Conditions
Brain Tumor
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 100 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 3 Interventional Results available

Topical Vancomycin for Neurosurgery Wound Prophylaxis

NCT02284126
View directory record Official record
Conditions
Infection, Surgery, Nervous System Diseases
Interventions
Vancomycin
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Early Phase 1 Interventional

Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia

NCT00993057
View directory record Official record
Conditions
Brain Neoplasms, Intracranial Aneurysm
Interventions
Insulin
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 4 Interventional Results available

Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy

NCT00734929
View directory record Official record
Conditions
Postoperative Nausea and Vomiting
Interventions
Aprepitant + Dexamethasone, Ondansetron + Dexamethasone
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 75 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 4 Interventional Results available

Intravenous Acetaminophen in Craniotomy

NCT01598701
View directory record Official record
Conditions
Postoperative Pain
Interventions
Acetaminophen, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 120 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 2Phase 3 Interventional Results available

IVPCA in the Management of Pain Following Major Intracranial Surgery

NCT00286221
View directory record Official record
Conditions
Intracranial Surgery
Interventions
PCA fentanyl, PRN fentanyl
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 4 Interventional Results available

The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period

NCT01739699
View directory record Official record
Conditions
Craniotomy, Brain Surgery
Interventions
Acetaminophen, Placebo
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Terminated Phase 4 Interventional Results available

Cranial Blocks for Postoperative Anesthesia

NCT04749797
View directory record Official record
Conditions
Craniotomy Surgery
Interventions
Liposomal bupivacaine, Bupivacaine Injection, Saline
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 4, 2026, 1:54 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Use of IV Acetaminophen in the Treatment of Post Operative Pain in Patients Undergoing Craniotomy and Spine Surgery

NCT03261310
View directory record Official record
Conditions
Postoperative Pain
Interventions
Acetaminophen or Placebo
Drug
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 90 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 1 Interventional Results available

Nicardipine vs Esmolol Craniotomy Emergence

NCT01951950
View directory record Official record
Conditions
Brain Tumors
Interventions
Nicardipine, Esmolol
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 28, 2014 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 1 Interventional

Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor

NCT00694330
View directory record Official record
Conditions
Glioma
Interventions
GM-K562 Vaccination
Biological
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Remifentanil and Dexmedetomidine for Craniotomy Perioperative Hemodynamics and Postoperative Pain

NCT01269918
View directory record Official record
Conditions
Adult Intracranial Tumor, Adult Solid Tumor
Interventions
Remifentanil, Dexmedetomidine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2016 · Synced Sep 4, 2026, 1:54 AM EDT
Withdrawn Not applicable Interventional

Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors

NCT00555984
View directory record Official record
Conditions
Brain Neoplasms
Interventions
Propofol + Remifentanil, Sevoflurane + Remifentanil
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed No phase listed Observational

The Management of Postoperative Craniotomy Pain in Pediatric Patients

NCT01576601
View directory record Official record
Conditions
Post Craniotomy Surgery, Cancer, Epilepsy, Vascular Malformations, Craniofacial Reconstructive Surgery
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
Up to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Baltimore, Maryland • Boston, Massachusetts • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2017 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 1 Interventional

Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients

NCT00024557
View directory record Official record
Conditions
Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Mixed Oligoastrocytoma, Malignant Astrocytoma
Interventions
IL13-PE38QQR, targeted fusion protein therapy, surgery
Drug · Procedure
Lead sponsor
INSYS Therapeutics Inc
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
4
States / cities
San Francisco, California • New Haven, Connecticut • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2011 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 3 Interventional

Surgery Versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastasis: A Randomized Trial

NCT00460395
View directory record Official record
Conditions
Brain Cancer
Interventions
Surgery, Stereotactic radiosurgery
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
16 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2005
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2012 · Synced Sep 4, 2026, 1:54 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

NCT05023434
View directory record Official record
Conditions
Brain Tumor, Brain Cancer, Motor Cortex; Lesion
Interventions
Intraoperative Brain Simulation - Alternate Stimulation Parameters
Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Recruiting Early Phase 1 Interventional

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

NCT06810336
View directory record Official record
Conditions
Brain Injury, Brain Tumors, Craniotomy Surgery, Pain, Postoperative, Postoperative Care
Interventions
Remifentanil, Methadone
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Recruiting Not applicable Interventional

A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.

NCT06201429
View directory record Official record
Conditions
Clinical Need for Craniotomy or Craniectomy, Clinical Need for Cranioplasty
Interventions
Mechanical Tissue Resuscitation™ (MTR®)
Device
Lead sponsor
Renovo Concepts, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Buffalo, New York • Winston-Salem, North Carolina • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery

NCT00848991
View directory record Official record
Conditions
Cranitomy Surgery
Interventions
Precedex, Propofol
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 9, 2012 · Synced Sep 4, 2026, 1:54 AM EDT
Completed No phase listed Observational

Craniofacial Surgery Perioperative Registry

NCT00658242
View directory record Official record
Conditions
Craniotomy
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Up to 18 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2013 · Synced Sep 4, 2026, 1:54 AM EDT
Recruiting Phase 2 Interventional

Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial

NCT06132685
View directory record Official record
Conditions
Low Grade Glioma, Malignant Brain Glioma, Malignant Brain Neoplasm, Meningioma
Interventions
Biospecimen Collection, Computed Tomography, Dexamethasone, Magnetic Resonance Imaging, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 4, 2026, 1:54 AM EDT
Withdrawn Not applicable Interventional

Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms

NCT00615381
View directory record Official record
Conditions
Intracranial Aneurysm
Interventions
Insulin
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 22, 2015 · Synced Sep 4, 2026, 1:54 AM EDT