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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:51 PM EDT

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Showing 1–24 of 606 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Critical Illness Clear all
Completed No phase listed Observational

Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19

NCT05336656
View directory record Official record
Conditions
COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
Interventions
Not listed
Lead sponsor
Wilkes University
Other
Eligibility
18 Years to 90 Years
Enrollment
353 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 20, 2026, 4:51 PM EDT
Withdrawn Phase 4 Interventional

Dexmedetomidine Cycling and Sleep in the Pediatric ICU

NCT05003102
View directory record Official record
Conditions
Critical Illness, Sedation Complication, Delirium
Interventions
Dexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 4 Interventional

Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial

NCT02497729
View directory record Official record
Conditions
Respiratory Failure
Interventions
Written Checklist, Head of Bed Up
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
5
States / cities
Birmingham, Alabama • New Orleans, Louisiana • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2016 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Intensive Care Unit (ICU) Diary Project

NCT04305353
View directory record Official record
Conditions
PTSD, Post ICU Syndrome
Interventions
Diary (blank journal) plus PTSD psycho-education, PTSD psycho-education alone
Other
Lead sponsor
Tulane University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

NCT03005145
View directory record Official record
Conditions
Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial
Interventions
7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
Other
Lead sponsor
Sunnybrook Health Sciences Centre
Other
Eligibility
18 Years and older
Enrollment
3,622 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
New York, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 4 Interventional

Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease

NCT03667703
View directory record Official record
Conditions
Congenital Heart Disease, Upper Gastrointestinal Bleeding, Stress Ulcer, Infection
Interventions
Famotidine, Placebo
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Minute to 12 Months
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 20, 2026, 4:51 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Neurochecks on Sleep in Critically Ill Adults

NCT05864300
View directory record Official record
Conditions
Cerebral Aneurysm
Interventions
Neurocheck frequency
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 3 Interventional

Oral Care to Reduce Mouth and Throat Infections in Critically Ill Patients

NCT00078663
View directory record Official record
Conditions
Critical Illness
Interventions
Oral Care
Behavioral
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland • Fairfax, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion

NCT00538616
View directory record Official record
Conditions
Brain Injury, Intracranial Pressure
Interventions
Dexmedetomidine, Propofol
Drug
Lead sponsor
Carmelo Graffagnino
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 11, 2013 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

Facilitating Communication Study

NCT03721952
View directory record Official record
Conditions
Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Multiple Organ Failure, Health Care Quality, Access, and Evaluation, Intensive Care Units, Palliative Care, Health Services, Palliative Care, Patient Care, Lung Diseases, Cerebrovascular Disorders, Brain Injuries
Interventions
Facilitator-Based Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
977 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Oct 20, 2026, 4:51 PM EDT
Withdrawn Phase 4 Interventional

High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy

NCT03846258
View directory record Official record
Conditions
Metabolic Acidosis, Acute Kidney Injury, Acute Kidney Failure
Interventions
Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 20, 2026, 4:51 PM EDT
Recruiting Not applicable Interventional

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

NCT06521086
View directory record Official record
Conditions
Trauma, Critical Illness
Interventions
Nutrition Supplements - Fresubin KCAL Drinks
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
45 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Not applicable Interventional

Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure

NCT01707303
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Early ICU rehabilitation strategies, Usual Care
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 20, 2026, 4:51 PM EDT
Completed No phase listed Observational

MICU Recovery Clinic

NCT02560129
View directory record Official record
Conditions
Critical Illness, Sepsis, Respiratory Failure, ARDS
Interventions
Questionnaires, Physical and Cognitive Function
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Not listed
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 7, 2024 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Not applicable Interventional Results available

24 Hour Intensivist Coverage in the Medical Intensive Care Unit

NCT01434823
View directory record Official record
Conditions
Critically Ill
Interventions
Nocturnal coverage
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,609 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 29, 2018 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 3 Interventional Results available

Midodrine for the Treatment of Refractory Hypotension

NCT01531959
View directory record Official record
Conditions
Hypotension, Critical Illness
Interventions
Midodrine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 28, 2020 · Synced Oct 20, 2026, 4:51 PM EDT
Completed No phase listed Observational

Clinician Ability to Predict the Presence of Nosocomial Pneumonia Based on Bronchoscopic Findings

NCT01904305
View directory record Official record
Conditions
Pneumonia
Interventions
Not listed
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2013 · Synced Oct 20, 2026, 4:51 PM EDT
Terminated Phase 4 Interventional Results available

A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function

NCT01712477
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Intravenous sedation using propofol, Intravenous sedation with midazolam
Drug
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 20, 2026, 4:51 PM EDT
Completed No phase listed Observational

Post-extubation Assessment of Laryngeal Symptoms and Severity

NCT03726086
View directory record Official record
Conditions
Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
Interventions
laryngoscopy
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Oct 20, 2026, 4:51 PM EDT
Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

NCT05440851
View directory record Official record
Conditions
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT
Other · Drug
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
6,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
27
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 20, 2026, 4:51 PM EDT
Not listed No phase listed Observational

Critical Illness Outcomes Study

NCT01109719
View directory record Official record
Conditions
Critical Illness, Intensive Care, Intensive Care Unit
Interventions
Not listed
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years and older
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 25, 2010 · Synced Oct 20, 2026, 4:51 PM EDT
Recruiting Not applicable Interventional

Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)

NCT07384585
View directory record Official record
Conditions
Circadian Dysregulation, Light Exposure, Pediatric Critical Illness
Interventions
Light Therapy
Other
Lead sponsor
Laura Beth Kalvas
Other
Eligibility
4 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 20, 2026, 4:51 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

NCT02105415
View directory record Official record
Conditions
Critical Illness
Interventions
Ketamine / Propofol Admixture, Etomidate
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 20, 2026, 4:51 PM EDT
Completed No phase listed Observational

Prospective Cohort Study of Intravenous Lipid Emulsion for Resuscitating Critically-ill Poisoned Patients

NCT03107689
View directory record Official record
Conditions
Overdose
Interventions
administration of intravenous lipid emulsion
Other
Lead sponsor
University of Southern California
Other
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Phoenix, Arizona • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2024 · Synced Oct 20, 2026, 4:51 PM EDT