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ClinicalTrials.gov public records Last synced Sep 6, 2026, 11:12 PM EDT

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Showing 1–24 of 294 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Critically Ill Patients Clear all
Terminated Phase 4 Interventional Results available

BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia

NCT05102162
View directory record Official record
Conditions
Pneumonia
Interventions
Cefepime, Meropenem, or Piperacillin/Tazobactam
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional

Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure

NCT01707303
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Early ICU rehabilitation strategies, Usual Care
Other
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Sep 6, 2026, 11:12 PM EDT
Not yet recruiting No phase listed Observational

TDAP in Burn Patients (Group 2)

NCT07223684
View directory record Official record
Conditions
Sepsis, Burn Injury, Wound Healing, Critical Illness, Multiple Organ Dysfunction Syndrome
Interventions
Observational Cohort (No Intervention)
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Tampa, Florida • Atlanta, Georgia • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 6, 2026, 11:12 PM EDT
Terminated Not applicable Interventional Results available

Utility of Vancomycin Loading: A Pharmacokinetic Analysis in Critically Ill Patients

NCT01157533
View directory record Official record
Conditions
Infection
Interventions
Vancomycin
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2013 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Phase 4 Interventional Results available

Safety and Efficacy of Saxagliptin for Glycemic Control in Non-Critically Ill Hospitalized Patient

NCT02182895
View directory record Official record
Conditions
Diabetes Mellitus
Interventions
Saxagliptin
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 110 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional Results available

24 Hour Intensivist Coverage in the Medical Intensive Care Unit

NCT01434823
View directory record Official record
Conditions
Critically Ill
Interventions
Nocturnal coverage
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,609 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2018 · Synced Sep 6, 2026, 11:12 PM EDT
Terminated Not applicable Interventional Results available

SCD Use to Prevent Deep Venous Thrombosis (DVT) in Patients With PICC Lines

NCT01670188
View directory record Official record
Conditions
Deep Vein Thrombosis
Interventions
Pneumatic SCD - VenaFlow System (DJO Global)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Sep 6, 2026, 11:12 PM EDT
Not listed No phase listed Observational

Study of Ceftazidime-Avibactam Blood Concentrations in Intensive Care Unit Patients With Renal Failure Requiring Continuous Dialysis

NCT03243864
View directory record Official record
Conditions
Renal Failure, Bacterial Infections, Critical Illness
Interventions
Ceftazidime-avibactam
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 6, 2026, 11:12 PM EDT
Recruiting Not applicable Interventional

The Effects of Endotracheal Suctioning on Pain and Serum Markers

NCT06692400
View directory record Official record
Conditions
Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation, Pain Measurement, Pain, Procedural, Oxidative Stress, Hypoxia, Biomarkers / Blood, Adult, Uric Acid, Sepsis, COVID, Influenza, Pneumonia
Interventions
endotracheal tube suctioning
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Phase 1 Interventional Results available

Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance

NCT04147221
View directory record Official record
Conditions
Sepsis
Interventions
Imipenem-relebactam
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 54 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Sep 6, 2026, 11:12 PM EDT
Terminated Not applicable Interventional Results available

Cycling of Sedative Infusions in Critically Ill Pediatric Patients

NCT01333059
View directory record Official record
Conditions
Respiratory Failure
Interventions
Midazolam, Normal saline, Fentanyl
Drug
Lead sponsor
Javier Gelvez, MD
Other
Eligibility
Up to 18 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Sep 6, 2026, 11:12 PM EDT
Completed No phase listed Observational

New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU Admission

NCT00106665
View directory record Official record
Conditions
Muscle Weakness, Critical Illness
Interventions
Not listed
Lead sponsor
Naeem Ali, MD
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
5
States / cities
Indianapolis, Indiana • Cincinnati, Ohio • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2016 · Synced Sep 6, 2026, 11:12 PM EDT
Active, not recruiting No phase listed Observational

Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future

NCT03905668
View directory record Official record
Conditions
Pain, Delirium
Interventions
Video Monitoring, Accelerometer Monitoring, Electromyographic Monitoring, Noise Level Monitoring, Light Level Monitoring
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional

Prognosticating Outcomes and Nudging Decisions With Electronic Records in the ICU Trial

NCT03139838
View directory record Official record
Conditions
Critical Illness
Interventions
EHR-Based Intervention A, EHR-Based Intervention B
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
10
States / cities
Albemarle, North Carolina • Charlotte, North Carolina • Lincolnton, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit

NCT00282594
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions
Novolin R (human recombinant Insulin)
Drug
Lead sponsor
Genesys
Other
Eligibility
18 Years and older
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 26, 2006 · Synced Sep 6, 2026, 11:12 PM EDT
Completed No phase listed Observational

Systolic Blood Pressure Measurement in Critically-ill Patients

NCT02366507
View directory record Official record
Conditions
Hypotension, Shock
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 6, 2026, 11:12 PM EDT
Recruiting Phase 4 Interventional

Magnesium Infusion for Pain Management in Critically Ill Trauma Patients

NCT04166877
View directory record Official record
Conditions
Trauma, Acute Pain
Interventions
Magnesium Sulfate in Parenteral Dosage Form, Normal saline placebo
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 6, 2026, 11:12 PM EDT
Completed No phase listed Observational

Treatment Intensity/Factors Predicting Short and Long Term Outcomes in Elderly Critically Ill Patients

NCT00554684
View directory record Official record
Conditions
Critically Ill Very Elderly Patients Admitted to ICU's
Interventions
Not listed
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
65 Years and older
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 22, 2012 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Phase 3 Interventional

Oral Care to Reduce Mouth and Throat Infections in Critically Ill Patients

NCT00078663
View directory record Official record
Conditions
Critical Illness
Interventions
Oral Care
Behavioral
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland • Fairfax, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 6, 2026, 11:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Curriculum for Airway Skills in Critically Ill Adults: a Delphi Evaluation

NCT06689748
View directory record Official record
Conditions
Airway Management, Tracheal Intubation, Critical Illness, Training
Interventions
Delphi procedure
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Phase 4 Interventional

Optimization of Beta-lactam Dosing in Critically Ill Patients With Cystatin C (OPTIMIZE-GNI)

NCT06709521
View directory record Official record
Conditions
Bacterial Infection
Interventions
Iohexol
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
10
States / cities
Torrance, California • Detroit, Michigan • Royal Oak, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19

NCT04373135
View directory record Official record
Conditions
Covid-19, Critical Illness, Attitude of Health Personnel, Attitude to Health, Health Behavior, Health Care Utilization
Interventions
Brief educational video
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
1,971 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 6, 2026, 11:12 PM EDT
Completed Not applicable Interventional

Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments

NCT04181294
View directory record Official record
Conditions
Critical Illness, Communication
Interventions
Family meetings using time limited trials as default ICU communication and care planning approach, Usual practice
Behavioral
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
3
States / cities
Los Angeles, California • Sylmar, California • Torrance, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 6, 2026, 11:12 PM EDT
Terminated Not applicable Interventional

Effect of Magnesium Sulfate Infusion Rate on Magnesium Retention in Critically Ill Patients

NCT01426165
View directory record Official record
Conditions
Primary Hypomagnesemia (Disorder)
Interventions
Magnesium Sulfate
Drug
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Sep 6, 2026, 11:12 PM EDT