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ClinicalTrials.gov public records Last synced Sep 14, 2026, 11:52 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Critically Illness Clear all
Completed No phase listed Observational

AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)

NCT04422808
View directory record Official record
Conditions
Withdrawal Syndrome, Iatrogenic Disease
Interventions
Not listed
Lead sponsor
Wilkes University
Other
Eligibility
18 Years and older
Enrollment
2,437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional

Prognosticating Outcomes and Nudging Decisions With Electronic Records in the ICU Trial

NCT03139838
View directory record Official record
Conditions
Critical Illness
Interventions
EHR-Based Intervention A, EHR-Based Intervention B
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
10
States / cities
Albemarle, North Carolina • Charlotte, North Carolina • Lincolnton, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 14, 2026, 11:52 AM EDT
Active, not recruiting Not applicable Interventional

12-hour Time Limited Feeding in Critical Care

NCT06741761
View directory record Official record
Conditions
Critical Illness
Interventions
12-hour time-restricted feeding (TRF12), Continuous 24 hour feeding (CONT24).
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Enteral Iron Supplementation in Critical Illness

NCT00450177
View directory record Official record
Conditions
Anemic, Critically Ill Patients
Interventions
Ferrous Sulfate, Placebo Oral Tablet
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional

Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.

NCT00675363
View directory record Official record
Conditions
Critical Illness
Interventions
Protocolized Sedation, Protocolized sedation, with daily interruption
Procedure
Lead sponsor
Mount Sinai Hospital, Canada
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Long Beach, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Sep 14, 2026, 11:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis

NCT01890928
View directory record Official record
Conditions
Sepsis, Hyperglycemia, Critical Illness
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
5 Years to 19 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2016 · Synced Sep 14, 2026, 11:52 AM EDT
Terminated Phase 2 Interventional Results available

TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

NCT03477903
View directory record Official record
Conditions
Critical Illness, Enteral Nutrition, Enteral Feeding Intolerance
Interventions
TAK-954, Metoclopramide, Normal Saline
Drug
Lead sponsor
Millennium Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
14
States / cities
Augusta, Georgia • Idaho Falls, Idaho • Peoria, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2019 · Synced Sep 14, 2026, 11:52 AM EDT
Active, not recruiting No phase listed Observational

Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study

NCT03098459
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma, Polytrauma, Traumatic Brain Injury, ICU, Critical Illness
Interventions
Non-interventional observational prospective cohort study
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience Among Surrogate Decision-Makers of ICU Patients

NCT03276559
View directory record Official record
Conditions
Critical Illness, Communication Disabilities
Interventions
EMPOWER, Enhanced Usual Care
Behavioral · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
3
States / cities
Flushing, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2024 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional Results available

Comparative Trial Between 3 Types of Insulin Infusion Protocols

NCT00582309
View directory record Official record
Conditions
Hyperglycemia
Interventions
Glucommander-Guided Intravenous Insulin Infusion, Standard Intravenous Insulin Infusion, Simple Calculated Intravenous Insulin Infusion
Procedure
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 80 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
3
States / cities
Chicago Heights, Illinois • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Sep 14, 2026, 11:52 AM EDT
Withdrawn Not applicable Interventional

Optimal Protein Supplementation for Critically Ill Patients

NCT01934595
View directory record Official record
Conditions
Critical Illness
Interventions
Beneprotein
Dietary Supplement
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 6, 2017 · Synced Sep 14, 2026, 11:52 AM EDT
Withdrawn Phase 2 Interventional

The Effect of Sodium Oxybate on Sleep Architecture

NCT00744393
View directory record Official record
Conditions
Mechanically Ventilated ICU Patients
Interventions
sodium oxybate, placebo
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Sep 14, 2026, 11:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill

NCT04755777
View directory record Official record
Conditions
Sepsis, Critical Illness
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
Gainesville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Sep 14, 2026, 11:52 AM EDT
Recruiting No phase listed Observational

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

NCT05055830
View directory record Official record
Conditions
Cardiac Disease, Critically Ill, Children, Adult
Interventions
The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care.
Drug
Lead sponsor
Duke University
Other
Eligibility
0 Months to 20 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Sep 14, 2026, 11:52 AM EDT
Not listed Not applicable Interventional

Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients

NCT04669444
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure, Renal Failure, Critical Illness, Pulmonary Disease
Interventions
Ventilator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 14, 2026, 11:52 AM EDT
Completed No phase listed Observational Results available

Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients

NCT03789396
View directory record Official record
Conditions
Trauma, Critical Illness, Oxygen Toxicity
Interventions
Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 109 Years
Enrollment
572 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 14, 2026, 11:52 AM EDT
Terminated Phase 2 Interventional Results available

Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial

NCT03003390
View directory record Official record
Conditions
Deep Venous Thrombosis
Interventions
Enoxaparin
Drug
Lead sponsor
Yale University
Other
Eligibility
Up to 17 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
6
States / cities
New Haven, Connecticut • St Louis, Missouri • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional

The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status

NCT00469482
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Critically Ill
Interventions
Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional

PERFormance Enhancement of the Canadian Nutrition Guidelines by a Tailored Implementation Strategy: The PERFECTIS Study

NCT01168128
View directory record Official record
Conditions
Critically Ill, Intensive Care Unit
Interventions
Tailored Change Strategy
Other
Lead sponsor
Daren K. Heyland
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Annapolis, Maryland • Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Sep 14, 2026, 11:52 AM EDT
Not listed Not applicable Interventional

Gastric US in ICU Patient

NCT05526105
View directory record Official record
Conditions
Critical Illness, Surgery, Aspiration Pneumonia
Interventions
Gastric Ultrasound
Diagnostic Test
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Early Phase 1 Interventional

Safety and Feasibility of Kefir Administration in Critically Ill Adults

NCT05416814
View directory record Official record
Conditions
Critically Ill
Interventions
Kefir
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Sep 14, 2026, 11:52 AM EDT
Not listed No phase listed Observational

Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

NCT02112604
View directory record Official record
Conditions
Critically Ill, Obstructive Sleep Apnea
Interventions
Ventilator, Alice PDx, Pulmonary function test, Muscle strength tests, Grip strength measurement, Sedatives and muscle relaxants given in the ICU
Device · Other · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 14, 2026, 11:52 AM EDT
Completed Not applicable Interventional

Family Functioning and Child Behavior When a Sibling is Critically Ill

NCT00912626
View directory record Official record
Conditions
Child Behavior
Interventions
One week follow up assessment results
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2015 · Synced Sep 14, 2026, 11:52 AM EDT
Recruiting Not applicable Interventional

Effect of Giving Reduced Fluid in Children After Trauma

NCT04201704
View directory record Official record
Conditions
Critical Illness, Pediatrics, General Surgery, Fluid Therapy, Wounds and Injuries
Interventions
Balanced crystalloid solution volume administration, Packed Erythrocytes Units, Blood Product Unit volume, Plasma volume, Platelets volume
Other
Lead sponsor
Columbia University
Other
Eligibility
6 Months to 15 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
4
States / cities
Buffalo, New York • New York, New York • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 14, 2026, 11:52 AM EDT