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ClinicalTrials.gov public records Last synced Sep 8, 2026, 7:16 PM EDT

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Showing 1–24 of 598 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Critically-ill Clear all
Recruiting Phase 2 Interventional

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

NCT07639359
View directory record Official record
Conditions
Critical Illness, Depressive Symptoms
Interventions
Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl)
Drug · Other
Lead sponsor
Hospital Italiano de Buenos Aires
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Not applicable Interventional Results available

Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness

NCT00709124
View directory record Official record
Conditions
Intensive Care Unit, Muscle Weakness
Interventions
Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA), Sham
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

NCT02548923
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 13, 2015 · Synced Sep 8, 2026, 7:16 PM EDT
Recruiting Not applicable Interventional

Improving Needs Among Older Adults

NCT06588556
View directory record Official record
Conditions
Critical Illness, Palliative Care, Older Adults, Informal Caregivers, Care Delivery Model
Interventions
ICUconnect, Usual care
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Birmingham, Alabama • New York, New York • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Phase 4 Interventional Results available

Minocycline Pharmacokinetics (ACUMIN)

NCT03369951
View directory record Official record
Conditions
Bacterial Infection
Interventions
Minocycline
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 99 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
15
States / cities
Decatur, Georgia • Chicago, Illinois • Lexington, Kentucky + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2020 · Synced Sep 8, 2026, 7:16 PM EDT
Recruiting Phase 3 Interventional

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

NCT06066502
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Respiratory Failure
Interventions
Precision ventilation, Guided usual care ventilation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
33
States / cities
Tucson, Arizona • Little Rock, Arkansas • La Jolla, California + 25 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Hypovitaminosis D in Neurocritical Patients

NCT02881957
View directory record Official record
Conditions
Craniocerebral Trauma, Intracranial Aneurysm, Brain Neoplasms, Spinal Cord Injuries, Seizures, Meningitis, Stroke, Intracranial Hemorrhages, Critical Illness, Vitamin d Deficiency
Interventions
Cholecalciferol, Placebo
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 14, 2022 · Synced Sep 8, 2026, 7:16 PM EDT
Not listed No phase listed Observational

Acute Encephalopathy in Critically Ill Patients With COVID-19

NCT04320472
View directory record Official record
Conditions
COVID-19, Encephalopathy, Critically Ill
Interventions
Follow up
Other
Lead sponsor
Ictal Group
Other
Eligibility
18 Years and older
Enrollment
250 participants
Timeline
2020
U.S. locations
2
States / cities
Miami, Florida • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 8, 2026, 7:16 PM EDT
Completed No phase listed Observational

New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children

NCT01511354
View directory record Official record
Conditions
Critically Ill
Interventions
Not listed
Lead sponsor
Texas A&M University
Other
Eligibility
Up to 18 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Sep 8, 2026, 7:16 PM EDT
Withdrawn Phase 3 Interventional

Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients

NCT00684164
View directory record Official record
Conditions
Hyponatremia
Interventions
Conivaptan, D5
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Sep 8, 2026, 7:16 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Location of Feeding on Glycemic Control in Critically Ill Patients (ELF)

NCT03566992
View directory record Official record
Conditions
Glucose Metabolism Disorders, Critical Illness
Interventions
Gastric
Procedure
Lead sponsor
Winchester Medical Center
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 8, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis

NCT01890928
View directory record Official record
Conditions
Sepsis, Hyperglycemia, Critical Illness
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
5 Years to 19 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2016 · Synced Sep 8, 2026, 7:16 PM EDT
Withdrawn No phase listed Observational

Computer-Aided, Non-Invasive, Acoustic Gastrointestinal Surveillance (AGIS) in ICU Patients

NCT02677909
View directory record Official record
Conditions
Critical Illness
Interventions
AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 8, 2026, 7:16 PM EDT
Terminated No phase listed Observational

Benefits of Post-Pyloric Feeding Tubes in Critically Ill Patients

NCT01343316
View directory record Official record
Conditions
Critical Illness
Interventions
Transpyloric feeding tubes (Nasogastric Tube (NG tube), Tiger2, Syncro BlueTube)
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 17, 2013 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Not applicable Interventional Results available

Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit

NCT03749330
View directory record Official record
Conditions
Communication, Critical Illness
Interventions
CICU Team And Loved Ones Communicating (CICU TALC)
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
451 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Phase 2 Interventional

The MIND Study: Modifying the INcidence of Delirium

NCT00096863
View directory record Official record
Conditions
Delirium, Cognition Disorders
Interventions
Ziprasidone, Haloperidol, Placebo
Drug · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
5
States / cities
Iowa City, Iowa • Chapel Hill, North Carolina • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2016 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Not applicable Interventional

Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients

NCT03948984
View directory record Official record
Conditions
Anxiety, Pain, Critical Illness, Relaxation
Interventions
Therapeutic Music Session
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Not applicable Interventional Results available

Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia

NCT03218397
View directory record Official record
Conditions
Gram-negative Bacteremia
Interventions
Accelerate PhenoTest™ BC Kit, Standard Culture and AST
Device
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Los Angeles, California • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Sep 8, 2026, 7:16 PM EDT
Completed No phase listed Observational

AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)

NCT04422808
View directory record Official record
Conditions
Withdrawal Syndrome, Iatrogenic Disease
Interventions
Not listed
Lead sponsor
Wilkes University
Other
Eligibility
18 Years and older
Enrollment
2,437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Sep 8, 2026, 7:16 PM EDT
Recruiting Not applicable Interventional

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

NCT06521086
View directory record Official record
Conditions
Trauma, Critical Illness
Interventions
Nutrition Supplements - Fresubin KCAL Drinks
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
45 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 8, 2026, 7:16 PM EDT
Completed Not applicable Interventional Results available

Mobile Mindfulness to Improve Psychological Distress After Critical Illness

NCT02701361
View directory record Official record
Conditions
Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder, Informal Caregivers, Family Members
Interventions
mobile mindfulness, standard mindfulness, education
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 8, 2026, 7:16 PM EDT
Not listed Not applicable Interventional

Peer Support for Post Intensive Care Syndrome Self-Management

NCT03788096
View directory record Official record
Conditions
Critical Illness, Sepsis, Shock, Septic, Shock, Respiratory Failure, Respiratory Distress Syndrome, Adult, Shock, Hypovolemic, Chronic Disease
Interventions
Peer Support with Motivational Interviewing, Usual Care Group
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Sep 8, 2026, 7:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood

NCT02225041
View directory record Official record
Conditions
Intellectual Disability, Perceptual Disorders, Memory Disorders
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Months to 13 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
31
States / cities
Birmingham, Alabama • Tucson, Arizona • Oakland, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Sep 8, 2026, 7:16 PM EDT
Terminated Not applicable Interventional Results available

Airway Pressure Release Ventilation in Acute Lung Injury

NCT00750204
View directory record Official record
Conditions
Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
Interventions
APRV, Conventional MV
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2017 · Synced Sep 8, 2026, 7:16 PM EDT