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ClinicalTrials.gov public records Last synced Oct 23, 2026, 10:43 AM EDT

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Showing 49–72 of 316 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Debility Clear all
Completed Phase 2 Interventional Results available

Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD)

NCT03359473
View directory record Official record
Conditions
Cachexia
Interventions
GSK2881078, Matching Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
50 Years to 75 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
5
States / cities
Torrance, California • Jacksonville, Florida • High Point, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Early Phase 1 Interventional Results available

CIMT and taVNS for Hemiplegia in Infants

NCT05101707
View directory record Official record
Conditions
Infant Development, Hemiplegia, Constraint Induced Movement Therapy
Interventions
transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
6 Months to 18 Months
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 23, 2026, 10:43 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test

NCT06348836
View directory record Official record
Conditions
Dynamic Knee Valgus
Interventions
Exercise
Other
Lead sponsor
Alvernia University
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Reading, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2024 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial Comparing Traditional Pelvic Floor Rehabilitation to Pilates in Increasing Pelvic Muscles Strength.

NCT00549458
View directory record Official record
Conditions
Muscle Weakness
Interventions
Pilates, Pelvic muscle rehabilitation therapy
Behavioral · Procedure
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 18, 2009 · Synced Oct 23, 2026, 10:43 AM EDT
Not listed Not applicable Interventional

Early Rehabilitation Using Functional Electrical Stimulation Assisted Supine Cycling in the Intensive Care Unit

NCT03554811
View directory record Official record
Conditions
ICU Acquired Weakness
Interventions
Functional electrical stimulation assisted supine cycling (FESC), Conventional early exercise and mobility interventions
Device · Other
Lead sponsor
Community Health System
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Aug 20, 2021 · Synced Oct 23, 2026, 10:43 AM EDT
Terminated Not applicable Interventional

Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit

NCT04160039
View directory record Official record
Conditions
Liver Cirrhoses, Liver Failure, ICU Acquired Weakness
Interventions
Cycle ergometry
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Phase 1 Interventional

Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis

NCT05451212
View directory record Official record
Conditions
MuSK Myasthenia Gravis
Interventions
MuSK-CAART
Biological
Lead sponsor
Cabaletta Bio
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
5
States / cities
Orange, California • Sacramento, California • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 10, 2025 · Synced Oct 23, 2026, 10:43 AM EDT
Active, not recruiting Not applicable Interventional Results available

Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome

NCT06238609
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness, Blood Flow
Interventions
Intervention Group, Control Group
Device
Lead sponsor
Bijan Najafi, PhD
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 30, 2024 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis

NCT00125658
View directory record Official record
Conditions
Cerebrovascular Accident
Interventions
Control, Experimental
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 23, 2017 · Synced Oct 23, 2026, 10:43 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Hydraulic Resistance and Older Adults

NCT06353438
View directory record Official record
Conditions
Aging, Fall, Old Age; Debility, Muscle Weakness
Interventions
Exercise Program
Other
Lead sponsor
College of Staten Island, the City University of New York
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility

NCT05815017
View directory record Official record
Conditions
Weakness, Muscle, Delirium in Old Age, Muscle Atrophy or Weakness, Muscle Loss, Hospital Acquired Condition, Physical Disability, Physical Inactivity
Interventions
Yoomi Physical Therapy Software
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Supplementary Dietary Protein (21g Per Day) on Lean Mass and Strength in Sedentary, Adult Vegetarians

NCT04076982
View directory record Official record
Conditions
Muscle Weakness
Interventions
mung bean protein, control biscuit
Dietary Supplement · Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 4, 2019 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional

Wearable Robotic Functional Assistance for Stroke Rehabilitation

NCT00396708
View directory record Official record
Conditions
CVA (Cerebrovascular Accident)
Interventions
myomo e100 neurorobotic elbow brace
Device
Lead sponsor
Myomo
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2010 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Evaluate the Effect of Ethinyl Estradiol/Norgestimate on the Pharmacokinetics of Lomitapide in Healthy Female Subjects

NCT02080468
View directory record Official record
Conditions
Healthy
Interventions
lomitapide, EE/norgestimate
Drug
Lead sponsor
Aegerion Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2019 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Results available

Diagnosing Intensive Care Unit (ICU) Acquired Weakness

NCT04166630
View directory record Official record
Conditions
ICU Acquired Weakness
Interventions
Clinical Electrical Stimulator
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional

CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients

NCT03471247
View directory record Official record
Conditions
Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
Interventions
In-Bed Cycle Ergometer, Routine PT
Device · Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
363 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 23, 2026, 10:43 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

NuroSleeve Powered Brace & Stimulation System to Restore Arm Function

NCT04798378
View directory record Official record
Conditions
Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies, Arthrogryposis, Spinal Cord Injuries, Charcot-Marie-Tooth, Stroke, Weakness of Extremities as Sequela of Stroke, Weakness Due to Upper Motor Neuron Dysfunction, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, Arm Paralysis, Cerebral Palsy
Interventions
Neurosleeve
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
4 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Wilmington, Delaware • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

NCT03789175
View directory record Official record
Conditions
Cancer, Skin Fibroblasts, Muscle Weakness
Interventions
Nicotinamide Riboside (NR)
Dietary Supplement
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Oct 23, 2026, 10:43 AM EDT
Terminated Not applicable Interventional

Treatment of Muscle Weakness in Critically Ill Patients

NCT02247895
View directory record Official record
Conditions
Critical Illness, Respiratory Failure, Myopathy, Weakness
Interventions
Sham Treatment, Electrical stimulation
Device
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 22, 2020 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protective Arm Balance Responses

NCT06388434
View directory record Official record
Conditions
Old Age; Debility, Peripheral Neuropathy
Interventions
Protective Arm Balance Response Training
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
45 Years to 88 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional

Nordic Hamstring Exercise After ACL Reconstruction Reconstruction

NCT05738200
View directory record Official record
Conditions
ACL Injury, Muscle Weakness, Neuromuscular Manifestations
Interventions
Nordic Hamstring Exercise
Other
Lead sponsor
University of Toledo
Other
Eligibility
18 Years to 35 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Influence of Oral Contraceptives During Disuse

NCT06275048
View directory record Official record
Conditions
Oral Contraceptives, Rehabilitation, Menstrual Cycle, Physical Therapy
Interventions
Wrist/hand immobilization
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 23, 2026, 10:43 AM EDT
Completed Phase 1Phase 2 Interventional

Result of tDCS in ASD Children With Comorbidities Like PANDAS, Rare Genetic Diseases or Autoimmune Disorders

NCT06368726
View directory record Official record
Conditions
Attention, Visual Perceptual Weakness, Social Behavior, Fluency Disorder, EEG With Periodic Abnormalities
Interventions
tDCS or Transcranial Direct Current Stimulation, Risperidone, Sham tDCS
Device · Drug · Other
Lead sponsor
Spanish Foundation for Neurometrics Development
Other
Eligibility
6 Years to 11 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 23, 2026, 10:43 AM EDT
Active, not recruiting Not applicable Interventional

EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)

NCT01701388
View directory record Official record
Conditions
Spinal Cord Injuries or Similar Neurological Weakness
Interventions
Ekso exoskeleton
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 23, 2026, 10:43 AM EDT