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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 3 Interventional

Health Effects of Silver-Mercury Dental Fillings

NCT00066118
View directory record Official record
Conditions
Caries, Dental
Interventions
Dental amalgam restorations
Device
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 12 Years
Enrollment
507 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2018 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Trial NuSmile Crowns

NCT04975321
View directory record Official record
Conditions
Primary Dental Caries, Multisurface Origin (Diagnosis)
Interventions
Nu Smile Zirconia crown, Nu Smile Pre Veneered crown, Composite strip crown
Device
Lead sponsor
University of Washington
Other
Eligibility
Up to 5 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cold Plasma for Dental Restoration and Caries Prevention

NCT01529606
View directory record Official record
Conditions
Dental Restoration, Caries
Interventions
Composite restoration and tooth cleaning, Plasma treatment
Other · Procedure
Lead sponsor
Nanova, Inc
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 15, 2020 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses

NCT02254993
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Kalispell, Montana • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Results available

Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI)

NCT02819479
View directory record Official record
Conditions
Radiation Necrosis
Interventions
25% Mannitol, Low-dose Intra-arterial Bevacizumab
Drug
Lead sponsor
Norton Healthcare
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Lexington, Kentucky • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 23, 2022 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Phase 3 Interventional

The Children's Amalgam Trial

NCT00065988
View directory record Official record
Conditions
Dental Caries
Interventions
Dispersed phase amalgam restoration /composite restoration
Device
Lead sponsor
Carelon Research
Other
Eligibility
6 Years to 10 Years
Enrollment
534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Watertown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 27, 2010 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healthy Hydration Pilot in Elementary Schools

NCT06132763
View directory record Official record
Conditions
Hydration, Dental Caries, Body Mass Index
Interventions
Hydration Intervention, Control - Assessments Only
Behavioral · Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
4 Years and older
Enrollment
563 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 4, 2026, 7:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Advancing Water Security: A Community Participatory School-Based Hydration Intervention

NCT06714929
View directory record Official record
Conditions
Dental Caries, Obesity Prevention
Interventions
Hydration
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
4 Years and older
Enrollment
7,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Henrico, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remineralization Effects of Hydroxyapatite Toothpaste

NCT03681340
View directory record Official record
Conditions
Caries, Dental
Interventions
Hydroxyapatite toothpaste, Fluoridated toothpaste
Other
Lead sponsor
Dr. Joachim Enax
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 21, 2019 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Use of Medical Grade Honey in the Prevention of Bone Anchored Hearing Aid Associated Skin Breakdown

NCT03929224
View directory record Official record
Conditions
Skin Infection
Interventions
Medicinal honey, Bacitracin
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 100 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Nutritional Counseling Tool in Reducing the Amount and Frequency of Sugar Intake

NCT06673342
View directory record Official record
Conditions
Dental Cavity, Caries,Dental
Interventions
Nutritional Counseling
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nutrition Knowledge for Spanish-speaking Parents

NCT01296945
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Kiosk, paper, Kiosk PLUS paper, Kiosk PLUS web
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2012 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional

CGM and DFU Healing Post-discharge

NCT06054659
View directory record Official record
Conditions
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
Interventions
Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
Device · Other · Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Atlanta, Georgia • Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 4, 2026, 7:42 PM EDT
Completed No phase listed Observational

Oral Alkali Production and Caries Prevention in Children (Longitudinal)

NCT02398695
View directory record Official record
Conditions
Dental Caries
Interventions
Oral Samples
Other
Lead sponsor
University of Florida
Other
Eligibility
2 Years to 7 Years
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects

NCT03196219
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2, Placebo
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Kalispell, Montana
Source: ClinicalTrials.gov public record
Updated Dec 21, 2022 · Synced Sep 4, 2026, 7:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances

NCT04186065
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Hiroko Nagaoka
Other
Eligibility
10 Years to 70 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries

NCT06949072
View directory record Official record
Conditions
Dental Caries
Interventions
Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 4, 2026, 7:42 PM EDT
Recruiting Not applicable Interventional

Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

NCT06727110
View directory record Official record
Conditions
Dental Caries
Interventions
PILP Cement, PILP Conditioner
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 4, 2026, 7:42 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project

NCT04556175
View directory record Official record
Conditions
Early Childhood Caries, Dental Caries
Interventions
Oral Health, Healthy Lifestyle
Behavioral
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Kykotsmovi, Arizona • Crow Agency, Montana
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children

NCT03294590
View directory record Official record
Conditions
Caries, Dental, Health Behavior
Interventions
OHT Parent targeted text messages, CWT Parent targeted text messages
Other
Lead sponsor
Boston University
Other
Eligibility
0 Months to 7 Years
Enrollment
754 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Sep 4, 2026, 7:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pandemic-adapted Caries Care Multicentre Single-group Interventional Study

NCT04666597
View directory record Official record
Conditions
Dental Caries in Children
Interventions
Modified CariesCare International management
Procedure
Lead sponsor
Universidad El Bosque, Bogotá
Other
Eligibility
3 Years to 8 Years
Enrollment
409 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Indianapolis, Indiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 3, 2023 · Synced Sep 4, 2026, 7:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Reasons for Replacement or Repair of Dental Restorations

NCT01201876
View directory record Official record
Conditions
Dental Caries
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
6 Years and older
Enrollment
6,368 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2011 · Synced Sep 4, 2026, 7:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Primary Care Beverage Study

NCT02257203
View directory record Official record
Conditions
Obesity, Dental Caries
Interventions
Sugar Sweetened Beverage Education, Reading Education
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2016 · Synced Sep 4, 2026, 7:42 PM EDT