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ClinicalTrials.gov public records Last synced Oct 21, 2026, 5:37 AM EDT

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Showing 169–192 of 241 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Decay Clear all
Not listed Phase 3 Interventional Accepts healthy volunteers

Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites

NCT00067392
View directory record Official record
Conditions
Dental Caries
Interventions
Dental Implant
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
21 Months to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 9, 2010 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses

NCT02254993
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Kalispell, Montana • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 3 Interventional

Xylitol Adult Caries Trial (X-ACT)

NCT00393055
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol, inactive lozenge
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 80 Years
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2011 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Histological Evaluation of Human Skin Bx to Assess the Effects of APR Tx as an Adjunct Procedure in Facelift Surgery

NCT06243744
View directory record Official record
Conditions
Skin Laxity, Tissue Degeneration, Tissue Breakdown, Collagen Degeneration, Collagen Shrinkage
Interventions
Renuvion APR System
Device
Lead sponsor
Apyx Medical
Industry
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
2
States / cities
Bradenton, Florida • Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Oral Hygiene Intervention Pilot Study

NCT02668809
View directory record Official record
Conditions
Dental Caries, Gingivitis
Interventions
oral health assessment, Questionnaires, Clinical Exam, Microbiological sampling, Monitoring Adherence, Varnish application, Consent, Educational Program
Other
Lead sponsor
Leonardo Marchini
Other
Eligibility
21 Years to 120 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 28, 2018 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional

Resin Polymer (NuSmile BioFlx) Compared to Stainless Steel Crowns (3M ESPE) for Restoration of Primary Molar Teeth

NCT06354634
View directory record Official record
Conditions
Dental Caries, Tooth Decay
Interventions
Resin polymer (NuSmile Bioflx) crown, Stainless steel crown
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 21, 2026, 5:37 AM EDT
Terminated Phase 2 Interventional Results available

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric

NCT03962634
View directory record Official record
Conditions
Caries,Dental, Apical Periodontitis
Interventions
Kovanaze Nasal Spray, Articaine Injection
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
6 Years to 18 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2020 · Synced Oct 21, 2026, 5:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

LT Comparative Effectiveness of 2 Caries Treatments

NCT07213661
View directory record Official record
Conditions
Dental Caries
Interventions
A "simple medical strategy" consisting of silver diamine fluoride (SDF), A "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride Varnish (FV)
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
62 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementing a Participatory, Multi-level Intervention to Improve Asian American Health Study

NCT03438045
View directory record Official record
Conditions
Oral Disease, Dental Caries
Interventions
Partnered intervention
Behavioral
Lead sponsor
NYU College of Dentistry
Other
Eligibility
18 Years to 100 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional

Using Video Modeled Social Stories to Improve Oral Hygiene in Children With Autism Spectrum Disorder

NCT02003820
View directory record Official record
Conditions
Autism Spectrum Disorder, Dental Caries
Interventions
video modeled social story
Behavioral
Lead sponsor
Yale University
Other
Eligibility
5 Years to 14 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 8, 2016 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Results available

Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal

NCT05248204
View directory record Official record
Conditions
Cavities of Teeth, Dental Decay
Interventions
Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years

NCT04068948
View directory record Official record
Conditions
Dental Caries in Children, Pediatric Dental Sedation, Meperidine, Hydroxyzine, Midazolam
Interventions
Meperidine, Hydroxyzine, Midazolam
Drug
Lead sponsor
University of Washington
Other
Eligibility
3 Years to 7 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects

NCT03004365
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2 Varnish, Placebo Varnish
Drug
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
3
States / cities
Kalispell, Montana • Bedford, Texas • Irving, Texas
Source: ClinicalTrials.gov public record
Updated Dec 29, 2022 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development and Evaluation of a Medical Intervention for Early Childhood Caries

NCT00464009
View directory record Official record
Conditions
Early Childhood Dental Caries
Interventions
Continuing medical education
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2010 · Synced Oct 21, 2026, 5:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Salivary Proteins in Disease and Health

NCT00100204
View directory record Official record
Conditions
Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome, Cystinosis, Head and Neck Neoplasms
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
264 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 5:37 AM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences

NCT07124533
View directory record Official record
Conditions
Gingival Inflammation, Dental Caries
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

NCT07419685
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ETT Rotation During Nasal Fiberoptic Intubation

NCT02405546
View directory record Official record
Conditions
Dental Caries
Interventions
Pre-Rotated (Group R), No pre-rotation
Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
2 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Enamel Remineralization Potential of Dentifrices in Situ

NCT01128946
View directory record Official record
Conditions
Dental Caries
Interventions
NaF, SnF, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 80 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 21, 2026, 5:37 AM EDT
Recruiting Phase 1 Interventional

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

NCT02531880
View directory record Official record
Conditions
Epilepsy
Interventions
Mangafodipir, Gadolinium
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Phase 2 Study to Evaluate the Microbiology and Safety of C16G2 Administered to Adult and Adolescent Dental Subjects

NCT02594254
View directory record Official record
Conditions
Dental Caries
Interventions
C16G2 Gel, Placebo
Drug · Other
Lead sponsor
Armata Pharmaceuticals, Inc.
Industry
Eligibility
12 Years to 75 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
10
States / cities
Imperial Beach, California • Indianapolis, Indiana • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Oct 21, 2026, 5:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Oral Health Intervention in Adult Primary Care

NCT06555029
View directory record Official record
Conditions
Dental Caries, Dry Mouth, Periodontal Diseases, Bleeding Gum
Interventions
EHR Changes, Medical Staff EHR Training, Clinician CSM theory-based didactic education and skills training, Standard ADA Oral Health Training
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
55 Years and older
Enrollment
929 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Oct 21, 2026, 5:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cold Plasma for Dental Restoration and Caries Prevention

NCT01529606
View directory record Official record
Conditions
Dental Restoration, Caries
Interventions
Composite restoration and tooth cleaning, Plasma treatment
Other · Procedure
Lead sponsor
Nanova, Inc
Industry
Eligibility
18 Years to 35 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Oct 21, 2026, 5:37 AM EDT