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ClinicalTrials.gov public records Last synced May 22, 2026, 3:53 AM EDT

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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Degeneration; Articular Cartilage, Knee Clear all
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
Episealer Knee System, Microfracture
Device · Procedure
Lead sponsor
Episurf Medical Inc.
Industry
Eligibility
30 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
8
States / cities
Tempe, Arizona • La Mesa, California • New Orleans, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced May 22, 2026, 3:53 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TissueGene-C, Normal Saline
Biological · Drug
Lead sponsor
Kolon TissueGene, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
5
States / cities
Pinellas Park, Florida • Baltimore, Maryland • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2016 · Synced May 22, 2026, 3:53 AM EDT
Not listed No phase listed Observational
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
Interventions
DeNovo NT, Natural Tissue Graft
Other
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
15
States / cities
Huntsville, Alabama • San Diego, California • Aurora, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced May 22, 2026, 3:53 AM EDT
Terminated Phase 3 Interventional
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
Biological · Other
Lead sponsor
ISTO Technologies, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
9
States / cities
Los Angeles, California • Santa Monica, California • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced May 22, 2026, 3:53 AM EDT
Completed Phase 1Phase 2 Interventional Results available
View directory record Official record
Conditions
Degeneration Articular Cartilage Knee
Interventions
CARTISTEM®
Biological
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chicago, Illinois • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced May 22, 2026, 3:53 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Degenerative Lesion of Articular Cartilage of Knee
Interventions
ADSC Application, Microfracture
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
3
States / cities
Redwood City, California • Santa Monica, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced May 22, 2026, 3:53 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Articular Cartilage Disorder of Knee, Articular Cartilage; Degeneration
Interventions
Autologous peripheral blood stem cells and hyaluronic acid, Hyaluronic acid
Biological · Other
Lead sponsor
KLSMC Stem Cells, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Aug 15, 2022 · Synced May 22, 2026, 3:53 AM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury, Defect of Articular Cartilage
Interventions
Chondrofix Osteochondral Allograft
Procedure
Lead sponsor
Zimmer Orthobiologics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
5
States / cities
Cos Cob, Connecticut • New Haven, Connecticut • Greenwood, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2014 · Synced May 22, 2026, 3:53 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Articular Cartilage Defect, Articular Cartilage Degeneration
Interventions
Autologous Chondrocyte Implantation (CartiLife®)
Drug
Lead sponsor
Biosolution Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
5
States / cities
Irvine, California • La Mesa, California • Lafayette, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced May 22, 2026, 3:53 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Knee Osteoarthritis, Cartilage Degeneration
Interventions
Teriparatide, Placebo
Drug
Lead sponsor
Christopher Ritchlin
Other
Eligibility
40 Years to 60 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced May 22, 2026, 3:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
25 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 26, 2011 · Synced May 22, 2026, 3:53 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis, ACL Tear, Cartilage Degeneration
Interventions
MRI
Diagnostic Test
Lead sponsor
Xiaojuan Li
Other
Eligibility
18 Years to 50 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced May 22, 2026, 3:53 AM EDT
Completed Phase 1Phase 2 Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Fisetin, Placebo oral capsule
Dietary Supplement · Drug
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
40 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced May 22, 2026, 3:53 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis, Osteoarthritis, Knee
Interventions
Clinic-based outpatient exercise group, Community-based exercise group
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2019 · Synced May 22, 2026, 3:53 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
Interventions
Autologous Mesenchymal Stem Cells
Biological
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced May 22, 2026, 3:53 AM EDT