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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:08 PM EST

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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Degeneration of Lumbar Intervertebral Disc Clear all

Conditions: Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation, Stenosis, Spondylolisthesis, Spondylolysis, Deformity of Spine
Interventions: Exparel, Bupivacaine; Drug
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Mount Holly, New Jersey

Conditions: Degenerative Disc Disease (DDD)
Interventions: FLD, Control; Device
Lead sponsor: AxioMed Spine Corporation; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 12
States / cities: Los Angeles, California • San Diego, California • Loveland, Colorado + 9 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: In this evaluation, no interventions are performed. It is a data collection effort only. The "procedure" for this study is the data collection effort.; Other
Lead sponsor: Spineology, Inc; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 197 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 10
States / cities: Fremont, California • Loma Linda, California • Napa, California + 7 more

Conditions: Degenerative Disc Disease
Interventions: ILIF; Procedure
Lead sponsor: NuVasive; Industry
Eligibility: 40 Years and older
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 8
States / cities: Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more

Conditions: Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Disease
Interventions: Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo; Drug · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 88 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Degenerative Disc Disease (DDD)
Interventions: Lumbar Interbody Fusion Devices; Device
Lead sponsor: Spine and Scoliosis Research Associates; Other
Eligibility: 18 Years to 110 Years
Enrollment: 465 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 4
States / cities: San Francisco, California • New York, New York • Charlotte, North Carolina + 1 more

Conditions: Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions: NSSD, Sham NSSD; Device
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California • Tampa, Florida

Conditions: Degenerative Disc Disease
Interventions: Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo; Drug
Lead sponsor: Mesoblast, Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 404 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 47
States / cities: Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 42 more

Conditions: Disc Degeneration
Interventions: MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment); Drug · Other
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lumbar Degenerative Disc Disease
Interventions: SB-01 For Injection, Sham Needle; Drug
Lead sponsor: Spine BioPharma, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 417 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 30
States / cities: Birmingham, Alabama • Phoenix, Arizona • Napa, California + 24 more

Conditions: Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
Interventions: Device: EVOS Lumbar Interbody System (EVOS-HA); Device
Lead sponsor: Invibio Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 2
States / cities: Charlotte, North Carolina • Philadelphia, Pennsylvania

Conditions: Degenerative Disc Disease
Interventions: INDEPENDENCE; Device
Lead sponsor: Globus Medical Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Temple, Texas

Conditions: Degenerative Disc Disease, Spondylolisthesis
Interventions: Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft; Device · Other
Lead sponsor: BioSurface Engineering Technologies, Inc; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 6
States / cities: Durango, Colorado • Washington D.C., District of Columbia • Kansas City, Kansas + 3 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: DIAM™ Spinal Stabilization System, Conservative care; Device · Procedure
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 311 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2018
U.S. locations: 29
States / cities: Scottsdale, Arizona • Beverly Hills, California • Los Angeles, California + 26 more

Conditions: Lumbar Degenerative Disc Disease
Interventions: PureGen Osteoprogenitor Cell Allograft; Biological
Lead sponsor: Alphatec Spine, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 3
States / cities: Beverly Hills, California • Middleton, Connecticut • Greensboro, North Carolina

Conditions: Degeneration Disc Intervertebral
Interventions: Abaloparatide, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis, Myelopathy, Radiculopathy, Myeloradiculopathy
Interventions: Methylprednisolone, Saline; Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: Not listed
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Degenerative Disc Disease
Interventions: Osteocel Plus; Biological
Lead sponsor: NuVasive; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Degenerative Disc Disease
Interventions: One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation; Procedure · Biological · Device
Lead sponsor: Kansas Joint and Spine Institute; Network
Eligibility: 18 Years to 70 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: Wichita, Kansas

Conditions: Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions: Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse; Biological
Lead sponsor: Mesoblast, Ltd.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 5
States / cities: Santa Monica, California • Greenwood Village, Colorado • Loveland, Colorado + 2 more

Conditions: Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions: Not listed
Lead sponsor: The Foundation for Spinal Research, Education and Humanitarian Care, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Odessa, Florida

Conditions: Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Degeneration, Spinal Stenosis
Interventions: Computed Tomography (CT) Scan of the Lumbar Spine; Radiation
Lead sponsor: Bone and Joint Clinic of Baton Rouge; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Degenerative Disc Disease, Spondylolisthesis, Spondylosis
Interventions: One or two level lumbar interbody fusion surgery, Nucel; Procedure · Other
Lead sponsor: Organogenesis; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 3
States / cities: Tampa, Florida • Shreveport, Louisiana • Charlotte, North Carolina

Conditions: Degenerative Lumbar Spondylolisthesis
Interventions: Not listed
Lead sponsor: Olympus Biotech Corporation; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 19
States / cities: Santa Monica, California • Stanford, California • Denver, Colorado + 16 more

Search by objective public record fields.

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease

Rampart Duo Clinical (RaDical) Post-Market Study

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

Effect of RECK in Posterior Spinal Fusion

Retro Comparison of Subsidence Following Interbody Devices in Lumbar Spine

Non-surgical Spinal Decompression Therapy and Outcomes

Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease

Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

INDEPENDENCE Spacer for Lumbar Fusion

Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery

Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care

Radiographic and Clinical Outcomes of PureGen in Posterior Lumbar (PLIF) and Transforaminal Interbody Fusion (TLIF)

Effect of Abaloparatide on Lumbar Disc Degeneration

Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion

Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)

Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

Fibergraft Interbody Fusion Retrospective

Study of Nucel for One and Two Level Lumbar Interbody Fusion

Study of OP-1 Putty in Uninstrumented Posterolateral Fusions