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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Degenerative Disc Disease Lumbar Clear all
Completed Not applicable Interventional

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine

NCT01968993
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive - posterolateral gutter
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
3
States / cities
La Jolla, California • San Francisco, California • Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational Results available

ViBone in Cervical and Lumbar Spine Fusion

NCT03425682
View directory record Official record
Conditions
Spondylosis, Cervical Spondylosis, Spondylolisthesis, Herniated Nucleus Pulposus, Degenerative Disc Disease
Interventions
ViBone
Other
Lead sponsor
Elutia Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
San Diego, California • Danbury, Connecticut • Annapolis, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Posterior Lumbar Interbody Fusion (PLIF)

NCT00941980
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

NCT01019057
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ILIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
40 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Withdrawn Phase 3 Interventional

Peri-Incisional Drug Injection in Lumbar Spine Surgery

NCT03513445
View directory record Official record
Conditions
Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
Interventions
Morphine, Epinephrine, naropin
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Jul 23, 2026, 10:13 AM EDT
Recruiting Not applicable Interventional

HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs

NCT06011551
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
The ReGelTec HYDRAFIL™ System, Conservative Care Management
Device · Other
Lead sponsor
ReGelTec, Inc.
Industry
Eligibility
22 Years to 85 Years
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
13
States / cities
Birmingham, Alabama • Santa Monica, California • Walnut Creek, California + 10 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Not listed No phase listed Observational

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

NCT02529566
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Odessa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Jul 23, 2026, 10:13 AM EDT
Recruiting No phase listed Observational

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

NCT05648474
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Interventions
Somatosensory evoked potential [SSEP] intraoperative monitoring
Diagnostic Test
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 23, 2026, 10:13 AM EDT
Active, not recruiting Not applicable Interventional

Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages

NCT05182489
View directory record Official record
Conditions
Spinal Canal Stenosis, Spondylolisthesis, Osteophyte, Bony Growth Formation, Degenerative Disc Disease
Interventions
Medtronic Adaptix™ titanium implants, Medtronic CAPSTONE® PEEK cage
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Completed Not applicable Interventional Results available

Prospective Study of Thoracolumbar Spinal Fusion Graft

NCT02297256
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
BMAC & Allograft, Iliac Crest Bone Graft
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
3
States / cities
New York, New York • Westbury, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Enrolling by invitation No phase listed Observational

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

NCT06000319
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Not listed Not applicable Interventional

Efficacy of Intradiscal Injection of Viable Placental Tissue Extract in Subjects With One or Two Level, Symptomatic Lumbar Intervertebral Disc Degeneration

NCT02379689
View directory record Official record
Conditions
Degenerative Disc Disease, Pain
Interventions
Injectable placental tissue extract called BioDGenesis (Active Product), Placebo
Drug
Lead sponsor
Semmes-Murphey Foundation
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Puyallup, Washington, Washington
Source: ClinicalTrials.gov public record
Updated Nov 16, 2015 · Synced Jul 23, 2026, 10:13 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

NCT05444751
View directory record Official record
Conditions
Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
Interventions
General anesthetic, SA + ESP
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Withdrawn Phase 2 Interventional

Effect of Abaloparatide on Lumbar Disc Degeneration

NCT03708926
View directory record Official record
Conditions
Degeneration Disc Intervertebral
Interventions
Abaloparatide, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 11, 2021 · Synced Jul 23, 2026, 10:13 AM EDT
Recruiting Phase 4 Interventional

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

NCT05029726
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions
Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
Drug
Lead sponsor
John O'Toole
Other
Eligibility
18 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Active, not recruiting Not applicable Interventional

P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation

NCT03438747
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
P-15L Bone Graft, Local autologous bone in a TLIF with Instrumentation
Device · Other
Lead sponsor
CeraPedics, Inc
Industry
Eligibility
22 Years to 80 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
34
States / cities
Birmingham, Alabama • Glendale, California • Los Angeles, California + 27 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Withdrawn Not applicable Interventional

Proprio Spine Measurement Tool

NCT07023393
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis, Spinal Osteophytosis, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Intraoperative spinal measurement system
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational

Advanced XLIF Monitoring Multicenter Study

NCT02272140
View directory record Official record
Conditions
Degenerative Lumbar Disc Disease
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 80 Years
Enrollment
324 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
12
States / cities
La Jolla, California • Tampa, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Not listed Not applicable Interventional

SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2

NCT04566874
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Scoliosis
Interventions
ALIF
Device
Lead sponsor
Camber Spine Technologies
Industry
Eligibility
22 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational

Advanced XLIF Monitoring Pilot Study

NCT02192112
View directory record Official record
Conditions
Degenerative Lumbar Disc Disease
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Durango, Colorado • Marrietta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion

NCT04057235
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
FlareHawk Interbody Fusion System
Device
Lead sponsor
Integrity Implants Inc.
Industry
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Savannah, Georgia • Charlotte, North Carolina • Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2020 · Synced Jul 23, 2026, 10:13 AM EDT
Terminated Not applicable Interventional

Comparative Analysis of Virtuos and Autograft in Lumbar Fusion

NCT05614284
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Virtuos
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
New Britain, Connecticut • Royal Oak, Michigan • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Jul 23, 2026, 10:13 AM EDT
Completed Not applicable Interventional

A-MAV™ Anterior Motion Segment Replacement

NCT00635934
View directory record Official record
Conditions
Spinal Diseases
Interventions
A-MAV™ disc
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years to 70 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Columbus, Georgia • Chesterfield, Missouri • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Jul 23, 2026, 10:13 AM EDT