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ClinicalTrials.gov public records Last synced Oct 7, 2026, 5:52 AM EDT

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Showing 73–96 of 144 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Disc Disease Lumbar Clear all
Recruiting Not applicable Interventional

Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes

NCT07222787
View directory record Official record
Conditions
Radiculopathy Lumbar, Degenerative Lumbar Disc Disease
Interventions
Supplemental Posterior Fusion with Study Device, Supplemental Posterior Fusion with Standard Technique
Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
12
States / cities
Scottsdale, Arizona • Los Angeles, California • Los Gatos, California + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated No phase listed Observational

OLIF25™ /OLIF51™ Study

NCT02657421
View directory record Official record
Conditions
Degenerative Disc Disease, Scoliosis
Interventions
Oblique Lateral Interbody Fusion
Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Murrieta, California • San Francisco, California • Melbourne, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2018 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel

NCT01028300
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ProDisc™-L Total Disc Replacement (TDR)
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Oct 7, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

OssiMend BA in Posterolateral Instrumented Lumbar Fusion

NCT04775537
View directory record Official record
Conditions
Spinal Disease, Degenerative Disc Disease
Interventions
OssiMend™ Bioactive Moldable
Device
Lead sponsor
Collagen Matrix
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
4
States / cities
Encinitas, California • Hartford, Connecticut • Somerset, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 7, 2026, 5:52 AM EDT
Completed No phase listed Observational

CHARITE™ vs. ALIF 5-Year Follow-up

NCT00215332
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
CHARITE
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
Not listed
Enrollment
367 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
10
States / cities
Los Angeles, California • Golden, Colorado • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Oct 7, 2026, 5:52 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Anterior Lumbar Interbody Fusion (ALIF)

NCT00948831
View directory record Official record
Conditions
Degenerative Disc Disease, Lumbar
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
7
States / cities
San Francisco, California • Indianapolis, Indiana • Kokomo, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Not applicable Interventional

Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction

NCT01326091
View directory record Official record
Conditions
Intervertebral Disk Degeneration
Interventions
Hyperlordotic Positioning
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2015 · Synced Oct 7, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT

NCT03884283
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis Lumbar
Interventions
FIBERGRAFT BG Matrix
Device
Lead sponsor
Prosidyan, Inc.
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
9
States / cities
Long Beach, California • Wellington, Florida • Paducah, Kentucky + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Results available

Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease

NCT02070484
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Spondylosis, Intervertebral Disk Displacement, Intervertebral Disk Degeneration, Spinal Diseases, Bone Diseases, Musculoskeletal Diseases, Spondylolysis
Interventions
NuCel, Demineralized Bone Matrix
Biological
Lead sponsor
OhioHealth
Other
Eligibility
18 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Oct 7, 2026, 5:52 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Study to Assess the Performance of MagnEtOs Flex Matrix Compared to Cellular Allograft

NCT06415123
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
MagnetOs Flex Matrix
Device
Lead sponsor
Research Source
Network
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 7, 2026, 5:52 AM EDT
Active, not recruiting Not applicable Interventional

Non-surgical Spinal Decompression Therapy and Outcomes

NCT06525896
View directory record Official record
Conditions
Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions
NSSD, Sham NSSD
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Stanford, California • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 7, 2026, 5:52 AM EDT
Completed Not applicable Interventional

A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions

NCT00679107
View directory record Official record
Conditions
Degenerative Lumbar Spondylolisthesis
Interventions
Use of OP-1 Putty in Uninstrumented posterolateral fusion
Device
Lead sponsor
Olympus Biotech Corporation
Industry
Eligibility
18 Years to 81 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
5
States / cities
New Haven, Connecticut • Chicago, Illinois • Royal Oak, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2011 · Synced Oct 7, 2026, 5:52 AM EDT
Completed No phase listed Observational

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

NCT01019057
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ILIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
40 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 7, 2026, 5:52 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion

NCT00810212
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
PLF with autograft, PLF with NeoFuse
Procedure · Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Oct 7, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Biologic Injection For Adults With Lumbar Disc Herniation

NCT07386548
View directory record Official record
Conditions
Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar, Degenerative Disc Disease, Lumbar, Lumbar Disc Herniation, Disc Herniation, Lumbar, Bone Marrow Aspirate Concentrate, Intervertebral Disc Displacement, Low Back Pain, Chronic Low Back Pain (CLBP), CLBP - Chronic Low Back Pain
Interventions
Bone Marrow Aspirate Concentrate (BMAC)
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Results available

AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY

NCT02704689
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Grade 1, Retrolisthesis
Interventions
AccuLIF expandable TLIF cage
Device
Lead sponsor
VB Spine, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Oct 7, 2026, 5:52 AM EDT
Withdrawn Phase 2 Interventional

Effect of Abaloparatide on Lumbar Disc Degeneration

NCT03708926
View directory record Official record
Conditions
Degeneration Disc Intervertebral
Interventions
Abaloparatide, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Oct 7, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion

NCT02628210
View directory record Official record
Conditions
Spondylosis, Spondylolisthesis, Degenerative Disc Disease
Interventions
map3® Cellular Allogeneic Bone Graft
Other
Lead sponsor
RTI Surgical
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
3
States / cities
Niagara Falls, New York • Williamsville, New York • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Oct 7, 2026, 5:52 AM EDT
Completed No phase listed Observational

Trinity Evolution in Posterior or Transforaminal Lumbar Interbody Fusion (PLIF/TLIF)

NCT00965380
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
15
States / cities
Boulder, Colorado • Canton, Connecticut • Middletown, Connecticut + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Oct 7, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages

NCT03647501
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Spinal Deformity, Lumbar Spondylosis
Interventions
Interbody cage (titanium), Interbody cage (PEEK)
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 7, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

NCT04679844
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Fusion, Back Pain
Interventions
MagnetOs Easypack Putty, Demineralized Bone Matrix or Fibers mixed with local autograft bone
Device
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Irvine, California • Grand Rapids, Michigan • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Phase 3 Interventional Results available

INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine

NCT01415908
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
INFUSE Bone Graft, Iliac Crest Bone Graft
Device · Other
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
5
States / cities
Mesa, Arizona • Los Angeles, California • Gulf Breeze, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Oct 7, 2026, 5:52 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease

NCT03692221
View directory record Official record
Conditions
Disc Degeneration
Interventions
MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment)
Drug · Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 7, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Multimodal Analgesia Versus Routine Care Pain Management

NCT01861743
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
Interventions
Multimodal Analgesia, Patient controlled analgesia
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 29, 2018 · Synced Oct 7, 2026, 5:52 AM EDT