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Showing 1–24 of 1,798 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Degenerative Joint Disease Clear all
Recruiting Phase 4 Interventional

Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty

NCT07775248
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Grosse Pointe Farms, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 2 Interventional Results available

Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis

NCT04886258
View directory record Official record
Conditions
Symptomatic Knee Osteoarthritis
Interventions
DFV890, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
50 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
7
States / cities
Phoenix, Arizona • El Cajon, California • Colorado Springs, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 3 Interventional

Efficacy of Acupuncture With Physical Therapy for Knee Osteo-Arthritis

NCT00035399
View directory record Official record
Conditions
Osteoarthritis
Interventions
Acupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
40 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2008 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 1 Interventional Results available

Safety Study of TissueGene-C in Degenerative Joint Disease of the Knee

NCT00599248
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TissueGene-C, Placebo
Biological
Lead sponsor
Kolon TissueGene, Inc.
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Baltimore, Maryland • Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 6, 2017 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Mobility Optimization Through Velocity Exercise

NCT00844558
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Training, Control
Other
Lead sponsor
University of Iowa
Other
Eligibility
60 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 5, 2016 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 2 Interventional Results available

Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee

NCT02205814
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Fasitibant- low dose, Fasitibant- intermediate dose, Fasitibant- high dose, Placebo comparator
Drug
Lead sponsor
Menarini Group
Industry
Eligibility
40 Years to 80 Years
Enrollment
436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
9
States / cities
Tucson, Arizona • Englewood, Colorado • DeLand, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Early Phase 1 Interventional

Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study

NCT02318433
View directory record Official record
Conditions
Distal Radius Fracture, Osteoarthritis
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 12, 2020 · Synced Sep 26, 2026, 5:01 AM EDT
Completed No phase listed Observational Results available

Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System

NCT02204748
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
DePuy Attune posterior stabilizing fixed bearing knee system
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
30 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Charlotte, North Carolina • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Sep 26, 2026, 5:01 AM EDT
Terminated Phase 3 Interventional Results available

Safety Extension Study Of Tanezumab When Administered By Subcutaneous Injection To Patients With Osteoarthritis

NCT01127893
View directory record Official record
Conditions
Osteoarthritis
Interventions
Tanezumab
Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2021 · Synced Sep 26, 2026, 5:01 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

NCT04435704
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Oxytocin
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Not applicable Interventional Results available

Non-Inferiority Study Comparing 3 Weekly Injections of SUPARTZ® vs 3 Weekly Injections of Euflexxa® for Knee OA

NCT02110238
View directory record Official record
Conditions
Osteoarthritis
Interventions
Supartz, Euflexxa
Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
40 Years to 80 Years
Enrollment
421 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Sep 26, 2026, 5:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury

NCT02010125
View directory record Official record
Conditions
Acute Injury of Anterior Cruciate Ligament
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years to 70 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 2 Interventional Results available

Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee

NCT01645176
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Hydroxychloroquine/Atorvastatin
Drug
Lead sponsor
Stanford University
Other
Eligibility
40 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Sep 26, 2026, 5:01 AM EDT
Not listed Not applicable Interventional

Multi-Site, Post-Market Study of the ICONACY I-Hip System

NCT02131389
View directory record Official record
Conditions
Degenerative Joint Disease
Interventions
Iconacy Hip System
Device
Lead sponsor
Iconacy Orthopedic Implants, LLC.
Industry
Eligibility
30 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 5, 2014 · Synced Sep 26, 2026, 5:01 AM EDT
Withdrawn Not applicable Interventional

Leisure Expectations About Physical Activity Study

NCT01938274
View directory record Official record
Conditions
Hip Osteoarthritis, Knee Osteoarthritis
Interventions
Educational intervention
Other
Lead sponsor
West Virginia University
Other
Eligibility
45 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 2 Interventional

Vitamin D to Slow Progression of Knee Osteoarthritis

NCT00306774
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Vitamin D (cholecalciferol), Placebo
Dietary Supplement
Lead sponsor
Tufts Medical Center
Other
Eligibility
45 Years to 90 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2011 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 2 Interventional

A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee

NCT02524197
View directory record Official record
Conditions
Osteoarthritis
Interventions
CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg, CR845 5 mg
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
25 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
5
States / cities
Omaha, Nebraska • Las Vegas, Nevada • Greensboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Sep 26, 2026, 5:01 AM EDT
Not listed No phase listed Observational

Intraoperative Soft Tissue Balance in TKA

NCT05006274
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Persona Trabecular Metal Tibia, Verasense technology, MUVR
Device
Lead sponsor
Washington Hospital Healthcare System
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Fremont, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 4 Interventional

Effects of Glucosamine and Chondroitin Supplementation in Women With Knee Osteoarthritis Participating in an Exercise and Weight Loss Program

NCT01271218
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Diet, Exercise
Other
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Jan 5, 2011 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Not applicable Interventional

Exercise Plus Activity Strategy Training for Osteoarthritis

NCT00613678
View directory record Official record
Conditions
Osteoarthritis
Interventions
Activity Strategy Training, Education
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
62 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

NCT05053087
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ropivacaine Continuous Infusion, Ropivacaine Intermittent Bolus, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Sep 26, 2026, 5:01 AM EDT
Active, not recruiting Phase 4 Interventional

Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)

NCT07006714
View directory record Official record
Conditions
Osteoarthritis, Vitamin D Deficiency
Interventions
Vitamin D3
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 96 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Sep 26, 2026, 5:01 AM EDT
Recruiting Phase 3 Interventional

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

NCT07509307
View directory record Official record
Conditions
Obesity, Overweight, Osteoarthritis, Knee
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
19
States / cities
Escondido, California • Lancaster, California • Palm Springs, California + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 26, 2026, 5:01 AM EDT
Completed Phase 3 Interventional

Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%

NCT01456611
View directory record Official record
Conditions
Osteo Arthritis of the Knee
Interventions
Diclofenac, Placebo
Drug
Lead sponsor
Anchen Pharmaceuticals, Inc
Industry
Eligibility
35 Years and older
Enrollment
749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
57
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 54 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Sep 26, 2026, 5:01 AM EDT