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ClinicalTrials.gov public records Last synced Sep 30, 2026, 3:49 AM EDT

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Showing 25–48 of 140 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Degenerative Spine Clear all
Terminated Phase 2 Interventional

Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease

NCT00878579
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
PDS System, Fusion
Device
Lead sponsor
Interventional Spine, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Cincinnati, Ohio • Willow Grove, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2013 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional

A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced Interbody Cages in the Lumbar Spine

NCT03928041
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1
Interventions
Device: EVOS Lumbar Interbody System (EVOS-HA)
Device
Lead sponsor
Invibio Ltd
Industry
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Completed No phase listed Observational

Posterior Lateral Fusion (PLF) With Dynesys

NCT00791180
View directory record Official record
Conditions
Spondylolisthesis
Interventions
Not listed
Lead sponsor
Zimmer Biomet
Industry
Eligibility
20 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2011 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional

Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion

NCT04679896
View directory record Official record
Conditions
Degenerative Disc Disease, Spine Fusion
Interventions
MagnetOs Putty
Device
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional Results available

OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion

NCT01873586
View directory record Official record
Conditions
Degenerative Changes, Stenosis, Spondylosis
Interventions
Posterolateral Fusion
Procedure
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Kenmore, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Phase 4 Interventional

Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis

NCT00000411
View directory record Official record
Conditions
Spinal Stenosis, Low Back Pain
Interventions
Decompressive laminectomy, Non-surgical treatments
Procedure · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2015
U.S. locations
13
States / cities
Oakland, California • San Francisco, California • Decatur, Georgia + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 4, 2015 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Early Phase 1 Interventional

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

NCT03088306
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Sep 30, 2026, 3:49 AM EDT
Completed No phase listed Observational

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

NCT05972616
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Natural Matrix Protein (NMP)
Biological
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional

A Pivotal Study of the Premia Spine TOPS™ System

NCT03012776
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Interventions
Total Posterior Spine System (TOPS), Transforaminal Lumbar Interbody Fusion (TLIF)
Device · Procedure
Lead sponsor
Premia Spine
Industry
Eligibility
35 Years to 80 Years
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
36
States / cities
Glendale, California • Los Angeles, California • Orange, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 30, 2026, 3:49 AM EDT
Recruiting Phase 4 Interventional

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

NCT05746143
View directory record Official record
Conditions
Spine Fusion, Lumbar Spine Degeneration, Pain, Postoperative, Lumbar Spine Spondylosis
Interventions
Zolpidem Tartrate 10 mg, Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 75 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Recruiting No phase listed Observational

Clinical Outcome Measure at Stryker Spine

NCT06226272
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Scoliosis
Interventions
Spinal Fusion, Spinal Deformities Correction
Device
Lead sponsor
VB Spine, LLC
Industry
Eligibility
18 Years and older
Enrollment
5,222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
7
States / cities
Jacksonville, Florida • Scarborough, Maine • Southfield, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Terminated Not applicable Interventional

Study of the Effect of Neck Treatment on Shoulder Impingement

NCT00764764
View directory record Official record
Conditions
Shoulder Impingement, Shoulder Pain, Rotator Cuff Tendinitis, Cervical Degenerative Joint Disease
Interventions
shoulder treatment, Shoulder AND cervical treatment
Procedure
Lead sponsor
CAMC Health System
Other
Eligibility
40 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Terminated Not applicable Interventional Results available

Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease

NCT02070484
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis, Spondylosis, Intervertebral Disk Displacement, Intervertebral Disk Degeneration, Spinal Diseases, Bone Diseases, Musculoskeletal Diseases, Spondylolysis
Interventions
NuCel, Demineralized Bone Matrix
Biological
Lead sponsor
OhioHealth
Other
Eligibility
18 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2018 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ISOVUE Comparative Trial

NCT07363759
View directory record Official record
Conditions
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
Interventions
ISOVUE 300 Observation, ISOVUE 300 Feedback
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Completed No phase listed Observational

Study Using the SpinalStim Device Following Lumbar Fusion Surgery

NCT03176303
View directory record Official record
Conditions
Lumbar Spine Degeneration
Interventions
SpinalStim
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Johnstown, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 16, 2022 · Synced Sep 30, 2026, 3:49 AM EDT
Not yet recruiting Not applicable Interventional

VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery

NCT07777679
View directory record Official record
Conditions
Degenerative Spine Disease, Spinal Stenosis Lumbar
Interventions
Virtual Reality-Based CBT Prehabilitation (VR-CBT), CBT Prehabilitation without Virtual Reality
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Irvine, California • Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 30, 2026, 3:49 AM EDT
Recruiting Not applicable Interventional

Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

NCT06485206
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
One level Mobi-C and one level fusion
Device
Lead sponsor
Highridge Medical
Industry
Eligibility
22 Years to 69 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Sacramento, California • Southfield, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Sep 30, 2026, 3:49 AM EDT
Withdrawn Phase 2 Interventional

Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severity of Difficulty Swallowing Foods and/or Liquids,Following Anterior Cervical Surgery

NCT03488147
View directory record Official record
Conditions
Dysphagia, GERD, Degenerative Joint Disease
Interventions
Esomeprazole, Placebo Oral Tablet
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 30, 2026, 3:49 AM EDT
Active, not recruiting Not applicable Interventional

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Anterior Cervical Discectomy and Fusion, Posterior Cervical Stabilization System (PCSS)
Procedure · Device
Lead sponsor
Providence Medical Technology, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
17
States / cities
Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Phase 4 Interventional Results available

BIO4 Clinical Case Study: Cervical Spine

NCT03077204
View directory record Official record
Conditions
Degenerative Disc Disease, Trauma (Including Fractures), Spondylolisthesis
Interventions
1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System
Biological · Device
Lead sponsor
Seton Healthcare Family
Other
Eligibility
19 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Sep 30, 2026, 3:49 AM EDT
Completed Not applicable Interventional

Physical Activity Intervention for Patients Following Lumbar Spine Surgery

NCT04591249
View directory record Official record
Conditions
Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Sep 30, 2026, 3:49 AM EDT
Not listed No phase listed Observational

Idys™ TLIF 3DTi Post Market Clinical Follow-up

NCT04584619
View directory record Official record
Conditions
Degenerative Disc Disease, Grade 1 Spondylolisthesis
Interventions
Spine fusion surgery with Clariance Idys TLIF 3DTi
Device
Lead sponsor
Clariance
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2021 · Synced Sep 30, 2026, 3:49 AM EDT
Recruiting No phase listed Observational

OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

NCT05452694
View directory record Official record
Conditions
Lumbar Spine Stenosis, Lumbar Spine Degeneration
Interventions
Not listed
Lead sponsor
OpalGenix, Inc
Industry
Eligibility
18 Years to 99 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 30, 2026, 3:49 AM EDT
Active, not recruiting Not applicable Interventional

Increasing Long-Term Physical Activity After Lumbar Spine Surgery

NCT02611427
View directory record Official record
Conditions
Lumbar Spine Degenerative Changes
Interventions
Education/Self-efficacy, Education
Behavioral
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 30, 2026, 3:49 AM EDT